Mouse Model News and Research

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Imran Noorani receives Brainlab Community Neurosurgery Abstract Award at 2016 CNS annual meeting

Imran Noorani MD, MRCS, of Cambridge, England, received the Brainlab Community Neurosurgery Abstract Award at the Congress of Neurological Surgeons Annual Meeting in San Diego.

28 Sep 2016

Researchers identify new immune cell that protects mice from lung infections during chemotherapy

St. Jude Children's Research Hospital investigators have identified a new form of an immune cell that protected mice from life-threatening lung infections under conditions that mimic cancer chemotherapy.

27 Sep 2016

Specific high-fat diets linked to increased tumor formation in mouse model of intestinal cancer

A high-fat-diet-induced immune reaction causes inflammation leading to intestinal cancer in a mouse model - even among animals that are not obese -- according to a new study from the Perelman School of Medicine at the University of Pennsylvania, Case Western Reserve University, the Pacific Northwest Research Institute, and others.

26 Sep 2016

Antibody drug offers new therapeutic approach for treating AML

An antibody drug that targets a surface marker on cancer stem cells could offer a promising new therapeutic approach for treating acute myeloid leukemia (AML), a form of blood cancer that affects an estimated 50,000 people in Saudi Arabia.

24 Sep 2016

Bile acid transporter inhibitors can prevent NASH in mice, study shows

Drugs that interfere with bile acid recycling can prevent several aspects of NASH (nonalcoholic steatohepatitis) in mice fed a high-fat diet, scientists from Emory University School of Medicine and Children's Healthcare of Atlanta have shown.

21 Sep 2016

Scientists use novel theranostics technique for early thromboembolism diagnosis and treatment

Researchers from the University of Arkansas for Medical Science (USA), in collaboration with University Hospital Frankfurt and University Hospital Dresden, under the supervision of Prof. Vladimir Zharov and with the participation of Alexander Melerzanov, the dean of Department of Biological and Medical Physics (MIPT), conducted experiments on mice to detect blood clotting using photoacoustic flow-cytometry.

21 Sep 2016

Mice study finds new antiviral that can control flu infection

A molecule the body produces naturally in response to virus infection could be a viable flu treatment in the future, suggest researchers at the Francis Crick Institute in London.

20 Sep 2016

Study shows retinoic acid could prevent postsurgical lymphedema

A study conducted at the Keck School of Medicine of the University of Southern California showed that 9-cis retinoic acid (alitretinoin) could significantly prevent postsurgical lymphedema.

16 Sep 2016

TSRI, IAVI scientists reveal new reductionist vaccine strategy to fight against HIV

A series of new studies led by scientists at The Scripps Research Institute and the International AIDS Vaccine Initiative describe a potential vaccination strategy to jump-start the selection and evolution of broadly effective antibodies to prevent HIV infection.

13 Sep 2016

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase. Caspase inhibitors have therapeutic potential to treat and prevent apoptosis-mediated liver injury, and some are currently in clinical trials.

9 Sep 2016

New mouse model helps identify potential drug target for hard-to-treat social aspects of ASD

A study of a new mouse model identifies a drug target that has the potential to increase social interaction in individuals with some forms of autism spectrum disorder (ASD), according to researchers in the Perelman School of Medicine at the University of Pennsylvania. The team published their work in Biological Psychiatry.

9 Sep 2016

Researchers reveal potential therapeutic treatment for alphavirus infections

Research conducted by Griffith University and Melbourne-based company Paradigm Biopharmaceuticals Limited has uncovered a potential new therapeutic treatment for the global battle against mosquito-borne alphavirus infections, including the debilitating Ross River Virus (RRV) and Chikungunya Virus (CHIKV).

8 Sep 2016

Stealth insulin-producing pig cells may offer solution for treating Type 1 diabetes in humans

University of Alabama at Birmingham researchers are exploring ways to wrap pig tissue with a protective coating to ultimately fight diabetes in humans. The nano-thin bilayers of protective material are meant to deter or prevent immune rejection.

8 Sep 2016

Experimental co-culture approach facilitates study of cellular events underlying Huntington's disease

Using an experimental co-culture approach in which two different types of neurons from a mouse model of Huntington's disease (HD) are grown side-by-side, connecting to form critically impacted circuits, researchers at University of California San Diego School of Medicine have identified a subunit of a protein that, when expressed, reverse the mutated gene effects responsible for HD.

6 Sep 2016

Researchers describe how genetic mutations cause unnamed neurological disorder

In rare cases -- for instance, among siblings in two families from Pakistan and Oman described in a new study -- children have been born with an unnamed neurological disorder.

6 Sep 2016

New discovery could potentially lead to treatments for Crohn's disease

Scientists at the University of British Columbia have made a discovery that could potentially lead to treatments for a debilitating complication of Crohn's disease.

2 Sep 2016

Six NIH-funded projects aim to identify biological factors that affect neural regeneration

The National Institutes of Health will fund six projects to identify biological factors that affect neural regeneration in the retina.

2 Sep 2016

MRSA correlated to eczema? An interview with Dr Bjorn Herpers

There is a lot of evidence that Staphylococcus aureus (S. aureus) is involved in eczema. Eczema is now thought to be caused by a barrier dysfunction of the skin that allows external triggers to cause an overshoot of inflammation.

31 Aug 2016

Scientists generate functional tissue-engineered liver from adult stem and progenitor cells

A research team led by investigators at The Saban Research Institute of Children's Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells.