Mouse Model News and Research

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Researchers create 2-for-1 vaccine that protects mice from MERS and rabies

In a new study, researchers have modified a rabies virus, so that it has a protein from the MERS virus; this altered virus works as a 2-for-1 vaccine that protects mice against both Middle East Respiratory Syndrome (MERS) and rabies.

7 Dec 2016

Researchers show how microRNAs play key role in tumor progression and response to radiation

OHSU researcher Sudarshan Anand, Ph.D., has a contemporary analogy to describe microRNA: "I sometimes compare MicroRNA to tweets -- they're short, transient and constantly changing."

2 Dec 2016

New mouse model provides key information for understanding cortical circuit development

A day by day log of cortical electric activity in the mouse visual cortex was published in the Journal of Neuroscience by George Washington University researcher Matthew Colonnese, Ph.D.

1 Dec 2016

Penn researchers use CRISPR/Cas9 gene targeting approach to treat hemophilia B in mice

CRISPR/Cas9, a powerful genome editing tool, is showing promise for efficient correction of disease-causing mutations.

1 Dec 2016

Scientists identify microrna that provides clues for quieting auditory hallucinations of schizophrenia

St. Jude Children's Research Hospital scientists have identified a small RNA (microRNA) that may be essential to restoring normal function in a brain circuit associated with the "voices" and other hallucinations of schizophrenia.

30 Nov 2016

New self-regulating smart patch releases blood-thinning drugs when necessary

An interdisciplinary team of researchers has developed a smart patch designed to monitor a patient's blood and release blood-thinning drugs as needed to prevent the occurrence of dangerous blood clots - a condition known as thrombosis.

29 Nov 2016

New cell reprogramming mechanism could pave way for potential therapies to boost tissue repair

Researchers have identified a mechanism by which cells undergo reprogramming in live mice, a phenomenon that had previously been poorly understood.

24 Nov 2016

New postnatal mouse model closely mimics fetal brain abnormalities caused by Zika infection

A team of scientists led by researchers at the University of Georgia has developed a new mouse model that closely mimics fetal brain abnormalities caused by the Zika virus in humans.

22 Nov 2016

TMDU researchers identify novel type of cell death in Huntington's disease

In Huntington's disease (HD), the huntingtin gene is mutated, causing progressive neuronal death.

22 Nov 2016

Messenger substance may help in future treatment of anxiety disorders

The targeted control of biochemical processes and neuronal signalling pathways using the messenger substance neuropeptide Y could help in the future treatment of anxiety disorders.

22 Nov 2016

Researchers develop new mouse model to study Zika virus and find potential treatments

Researchers have developed a new mouse model that could be used in Zika research to better understand the virus and find new treatments, according to a study published in PLOS Pathogens.

18 Nov 2016

Study finds way to detect early signs of AD by looking at retina of patients' eyes

A new study from The University of Texas Medical Branch at Galveston offers important insight into how Alzheimer's disease begins within the brain.

18 Nov 2016

Scientists develop genetically engineered T cells with fusion inhibitor to disrupt HIV's harpoon

When HIV attacks a T cell, it attaches itself to the cell's surface and launches a "harpoon" to create an opening to enter and infect the cells.

18 Nov 2016

New mouse model by FDA's scientists provides platform for improving understanding of Zika virus pathology

A new mouse model developed by scientists at the U.S. Food and Drug Administration may help in exploring the potential activity of Zika virus vaccines and therapeutics.

17 Nov 2016

Promethera presents new preclinical NASH-Fibrosis data from HepaStem program at AASLD meeting

Promethera Biosciences SA, a world-leading cell therapy and regenerative medicine company targeting liver diseases, today announced the presentation of new preclinical NASH-Fibrosis data from its proprietary HepaStem program, demonstrating a beneficial effect of HepaStem in a nonalcoholic steatohepatitis (NASH) mouse model and confirming Hepastem’s unique and multifaceted mode of action.

15 Nov 2016

Researchers create first mouse model for common form of infant leukemia

After nearly two decades of unsuccessful attempts, researchers from the University of Chicago Medicine and the Cincinnati Children's Hospital Medical Center have created the first mouse model for the most common form of infant leukemia.

15 Nov 2016

Deficiency of tumor suppressor gene may allow brain cancer cells to survive outside niches

Astronauts survive in space by wearing high-tech space suits. But how do brain cancer cells thrive when they migrate to inhospitable sites within the brain?

14 Nov 2016

New research explains how tumors may impair ability of the liver to respond to caloric deprivation

One of the worst cruelties of lethal cancer is the phenomenon called wasting, or in medical terms, cachexia (pronounced ka-CHEX-ia), in which a patient seems literally to diminish in bodily terms as the cancer ravages one or more internal organs.

8 Nov 2016

New mouse models may open ways to develop therapies for ALS patients

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive, fatal neurological disease that attacks the nerve cells controlling voluntary muscles. No effective treatments have been found.

7 Nov 2016

Researchers describe new method that can reveal distinct invasive properties of cancer cells

A research team at Georgetown Lombardi Comprehensive Cancer Center has described the steps, in both written and video format, that allow cancer investigators to track, in real time, cancer cell invasion and metastasis in transparent zebrafish embryos.

4 Nov 2016

Mouse Model News and Research

Researchers create 2-for-1 vaccine that protects mice from MERS and rabies

Researchers show how microRNAs play key role in tumor progression and response to radiation

New mouse model provides key information for understanding cortical circuit development

Penn researchers use CRISPR/Cas9 gene targeting approach to treat hemophilia B in mice

Scientists identify microrna that provides clues for quieting auditory hallucinations of schizophrenia

New self-regulating smart patch releases blood-thinning drugs when necessary

New cell reprogramming mechanism could pave way for potential therapies to boost tissue repair

New postnatal mouse model closely mimics fetal brain abnormalities caused by Zika infection

TMDU researchers identify novel type of cell death in Huntington's disease

Messenger substance may help in future treatment of anxiety disorders

Researchers develop new mouse model to study Zika virus and find potential treatments

Study finds way to detect early signs of AD by looking at retina of patients' eyes

Scientists develop genetically engineered T cells with fusion inhibitor to disrupt HIV's harpoon

New mouse model by FDA's scientists provides platform for improving understanding of Zika virus pathology

Promethera presents new preclinical NASH-Fibrosis data from HepaStem program at AASLD meeting

Researchers create first mouse model for common form of infant leukemia

Deficiency of tumor suppressor gene may allow brain cancer cells to survive outside niches

New research explains how tumors may impair ability of the liver to respond to caloric deprivation

New mouse models may open ways to develop therapies for ALS patients

Researchers describe new method that can reveal distinct invasive properties of cancer cells

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