Protein C News and Research

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Combining 5-fluorouracil and IL-1 beta inhibitor can improve effectiveness of chemotherapy

These results reveal how the immune system can then limit the effectiveness of some cancer chemotherapies. The researchers now intend to block the molecules responsible for negative immune system activation to increase the efficiency of chemotherapy. A clinical trial to test this hypothesis should begin very soon.

5 Dec 2012

Bioinformaticians use molecular simulations to explain specific step in HIV virion maturation

Bioinformaticians at IMIM (Hospital del Mar Medical Research Institute) and UPF (Pompeu Fabra University) have used molecular simulation techniques to explain a specific step in the maturation of the HIV virions, i.e., how newly formed inert virus particles become infectious, which is essential in understanding how the virus replicates.

5 Dec 2012

Dietary fish oil supplements could help heal bedsores

Chock-full of Omega-3 fatty acids and antioxidants, fish oil can help lower blood pressure, reduce inflammation in the skin and joints, and promote healthy fetal development. Now a Tel Aviv University researcher has found that it has a positive effect on bedsores, too.

5 Dec 2012

Sputum color guides antibiotic treatment in COPD

Withholding antibiotic treatment from hospitalized chronic obstructive lung disease patients with nonpurulent sputum does not negatively affect outcomes, a pilot study shows.

4 Dec 2012

Talk is cheap for tackling wasteful emergency diagnostics

An intervention as simple as a staff discussion during a general meeting results in a large reduction in the number of unnecessary diagnostic tests ordered by emergency physicians, say Brazilian researchers.

4 Dec 2012

Adiponectin level may underpin atherogenic haptoglobin phenotype

Researchers have suggested an active role for adiponectin in the pathophysiology of vascular disease in patients with diabetes, that depends on their haptoglobin phenotype.

4 Dec 2012

Hebrew University researchers pave way for development of new approaches to cure malaria

More than a million people die each year of malaria caused by different strains of the Plasmodium parasite transmitted by the Anopheles mosquito. The medical world has yet to find an effective vaccine against the deadly parasite, which mainly affects pregnant women and children under the age of five. By figuring out how the most dangerous strain evades the watchful eye of the immune system, researchers from the Hebrew University of Jerusalem have now paved the way for the development of new approaches to cure this acute infection.

4 Dec 2012

psi-GSH prevents neurodegeneration associated with Alzheimer's in mouse model

Researchers at the University of Minnesota's Center for Drug Design have developed a synthetic compound that, in a mouse model, successfully prevents the neurodegeneration associated with Alzheimer's disease.

4 Dec 2012

New antibodies effective at preventing formation of toxic protein particles linked to Parkinson’s, AD

Antibodies developed by researchers at Rensselaer Polytechnic Institute are unusually effective at preventing the formation of toxic protein particles linked to Alzheimer's disease and Parkinson's disease, as well as Type 2 diabetes, according to a new study.

4 Dec 2012

Researchers describe role of calcium in ability of Yersinias to cause disease

A more than 50-year-old question has now been answered. Chemists and microbiologists at the Biological Chemistry Center at Umeå University in Sweden are now able to describe in detail the role of calcium in the ability of the plague bacterium Yersinias to cause disease.

4 Dec 2012

Study describes 68 cases of chronic traumatic encephalopathy in athletes, military veterans

A study done by investigators at the Boston University Center for the Study of Traumatic Encephalopathy (CSTE) and the Veterans Affairs Boston Healthcare System, in collaboration with the Sports Legacy Institute (SLI), describes 68 cases of chronic traumatic encephalopathy (CTE) among deceased athletes and military veterans whose brain and spinal cords were donated to the VA CSTE Brain Bank.

4 Dec 2012

Researchers discover first-ever mouse model of diffuse idiopathic skeletal hyperostosis

Researchers at Western University have made a breakthrough that could lead to a better understanding of a common form of arthritis that, until now, has eluded scientists.

4 Dec 2012

Scientists discover new target molecule for development of treatment against Alzheimer's

Scientists from VIB and KU Leuven have discovered a new target molecule for the development of a treatment against Alzheimer's disease. There is currently no cure for this disease.

3 Dec 2012

Merck commences MK-8931 Phase II/III trial in Alzheimer's

Merck, known as MSD outside the United States and Canada, announced it has started a Phase II/III clinical trial designed to evaluate the safety and efficacy of MK-8931 versus placebo in patients with mild-to-moderate Alzheimer's disease.

3 Dec 2012

microRNAs play an important role during embryonic development

Sanford-Burnham researchers discover that microRNAs play an important role in germ layer formation-the process that determines which cells become which organs during embryonic development

3 Dec 2012

Vasculitis and the metabolic syndrome frequently co-exist

The metabolic syndrome is significantly more common in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis than healthy individuals, researchers have found.

3 Dec 2012

Inflammatory marker targeted in ear infection

Systemic injection of an antibody against granulocyte/macrophage colony-stimulating factor inhibits middle-ear inflammation induced by lipopolysaccharide in mice, study findings show.

3 Dec 2012

Specific transporters could be exploited to deliver toxic substances into cancer cells

Whitehead Institute scientists report that certain molecules present in high concentrations on the surfaces of many cancer cells could be exploited to funnel lethal toxic molecules into the malignant cells. In such an approach, the overexpression of specific transporters could be exploited to deliver toxic substances into cancer cells.

3 Dec 2012

Children with changes in bully genes have poor survival

In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia (CHOP) found that patients with changes in two genes, ARID1A and ARID1B, survive only a quarter as long as patients without the changes. The discovery could eventually lead to early identification of patients with aggressive neuroblastomas who may need additional treatments.

3 Dec 2012

TINCR molecule plays a master role in epidermal differentiation

The surface of your skin, called the epidermis, is a complex mixture of many different cell types - each with a very specific job. The production, or differentiation, of such a sophisticated tissue requires an immense amount of coordination at the cellular level, and glitches in the process can have disastrous consequences. Now, researchers at the Stanford University School of Medicine have identified a master regulator of this differentiation process.

2 Dec 2012

Protein C News and Research

Combining 5-fluorouracil and IL-1 beta inhibitor can improve effectiveness of chemotherapy

Bioinformaticians use molecular simulations to explain specific step in HIV virion maturation

Dietary fish oil supplements could help heal bedsores

Sputum color guides antibiotic treatment in COPD

Talk is cheap for tackling wasteful emergency diagnostics

Adiponectin level may underpin atherogenic haptoglobin phenotype

Hebrew University researchers pave way for development of new approaches to cure malaria

psi-GSH prevents neurodegeneration associated with Alzheimer's in mouse model

New antibodies effective at preventing formation of toxic protein particles linked to Parkinson’s, AD

Researchers describe role of calcium in ability of Yersinias to cause disease

Study describes 68 cases of chronic traumatic encephalopathy in athletes, military veterans

Researchers discover first-ever mouse model of diffuse idiopathic skeletal hyperostosis

Scientists discover new target molecule for development of treatment against Alzheimer's

Merck commences MK-8931 Phase II/III trial in Alzheimer's

microRNAs play an important role during embryonic development

Vasculitis and the metabolic syndrome frequently co-exist

Inflammatory marker targeted in ear infection

Specific transporters could be exploited to deliver toxic substances into cancer cells

Children with changes in bully genes have poor survival

TINCR molecule plays a master role in epidermal differentiation

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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