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Malaria approaches must be adjusted to account for local contexts, 'changing realities'

Noting "April 25 marks World Malaria Day, an opportunity for those who work to defeat the illness to review progress and renew commitments," Laurence Slutsker and Patrick Kachur of the CDC's Division of Parasitic Diseases and Malaria, write in a Malaria Journal opinion piece, "After a decade of steady success, this year's commemoration of the date is also an opportunity to reconsider current approaches and assess the state of the science needed to keep pace in the global effort to combat malaria."

25 Apr 2013

Study: Melatonin delays symptom onset, reduces mortality in mouse model of ALS

Melatonin injections delayed symptom onset and reduced mortality in a mouse model of the neurodegenerative condition amyotrophic lateral sclerosis, or Lou Gehrig's disease, according to a new study by researchers at the University of Pittsburgh School of Medicine.

25 Apr 2013

U.S. files suit against Novartis in alleged kickback scheme

The suit accuses the drugmaker of giving pharmacies discounts and rebates to promote the use of the drug Myfortic.

25 Apr 2013

FDA announces public-private partnership to identify counterfeit anti-malarial medicines with CD-3

The U.S. Food and Drug Administration today announced a public-private partnership to help identify counterfeit or substandard anti-malarial medicines, including falsified products, with the deployment of the FDA-developed Counterfeit Detection Device, called CD-3.

25 Apr 2013

WHO highlights threat of antimalarial drug resistance in Greater Mekong subregion

On World Malaria Day, 25 April, WHO recognizes significant accomplishments in preventing and controlling malaria, including in high-burden countries in sub-Saharan Africa, but highlights the threat of antimalarial drug resistance in south-east Asia's Greater Mekong subregion, where an emergency response is now being launched.

25 Apr 2013

Sofosbuvir is safer than interferon for hepatitis C patients, say scientists

A new drug is offering dramatic cure rates for hepatitis C patients with two subtypes of the infection -- genotype 2 and 3, say a team of scientists led by Weill Cornell Medical College researchers.

25 Apr 2013

Roundup: Calif. health care cuts attract opponents; Health law means fewer hours for Va. community college instructors

In the health care world, there's not a whole lot that insurers, doctors and union workers all agree on. But a new coalition of powerful Capitol players from all three groups is hoping to reverse recent budget cuts, pushed by Gov. Jerry Brown, to those who provide care to the poorest Californians.

25 Apr 2013

Individuals with MEN1 are at increased risk of developing neuroendocrine tumors

A mutation in a protein called menin causes a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1).

25 Apr 2013

First Edition: April 24, 2013

Today's headlines include stories about the health law's implementation as well as health policy developments from Capitol Hill.

24 Apr 2013

Researchers decode toggle switch that can stimulate fat burning

For a long time, scientists have dreamt of converting undesirable white fat cells into brown fat cells and thus simply have excess pounds melt away. Researchers at the University of Bonn have now gotten a step closer to this goal: They decoded a "toggle switch" in mice which can significantly stimulate fat burning.

24 Apr 2013

South Africa aims to close drug patent loophole that allows for 'ever-greening'

"South Africa plans to overhaul its intellectual property laws to improve access to cheaper medicines by making it harder for pharmaceutical firms to register and roll-over patents for drugs, a senior official said on Monday," Reuters reports.

24 Apr 2013

Nanogels to attack lupus: an interview with Dr Look and Dr Fahmy, Yale University

Nanogels are synthetic particles that can be used for drug delivery. They are approximately 100 nm to 200 nm in diameter, and are made from safe, biocompatible materials: a gel-like interior and a lipid exterior.

24 Apr 2013

Study identifies malaria parasite protein as potential new target for drug treatment to prevent malaria

Scientists have discovered how a protein within the malaria parasite is essential to its survival as it develops inside a mosquito. They believe their findings identify this protein as a potential new target for drug treatments to prevent malaria being passed to humans.

24 Apr 2013

Viewpoints: Time to confirm Tavenner; 'Self-defeating' GOP plan for prevention fund; Parents need insurance too

The Senate Finance Committee is scheduled to hold a long-overdue vote on Tuesday on President Obama's nominee to lead the embattled agency responsible for overseeing Medicare, Medicaid and the implementation of health care reforms.

24 Apr 2013

FDA grants orphan-drug designation to XEN402 for treatment of pain associated with EM

Teva Pharmaceutical Industries Ltd. and Xenon Pharmaceuticals Inc. announced today that the US Food and Drug Administration has granted orphan-drug designation to the investigational drug XEN402 being developed for the treatment of pain associated with erythromelalgia.

24 Apr 2013

BD receives FDA approval for second prefilled injectable drug

BD Rx Inc., a wholly-owned subsidiary of leading global medical technology company BD, announced today that the U.S. Food and Drug Administration has approved the second drug to be offered in the recently launched BD Simplist line of ready-to-administer prefilled generic injectables.

From BD (Becton, Dickinson and Company) 24 Apr 2013

Isis Pharmaceuticals starts ISIS-SMNRx Phase 2 study in infants with SMA

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 2 study of ISIS-SMNRx in infants with spinal muscular atrophy. SMA is a severe and rare genetic neuromuscular disease characterized by muscle atrophy and weakness and is the most common genetic cause of infant mortality.

24 Apr 2013

PPMI to launch additional study to evaluate multiple potential biomarkers for Parkinson's disease

The Parkinson's Progression Markers Initiative, a landmark biomarker clinical study, has completed enrollment of its initial 600-member cohort of Parkinson's patients and controls, and will launch additional study cohorts to leverage the existing PPMI infrastructure and evaluate multiple potential biomarkers for Parkinson's disease.

24 Apr 2013

Maternal use of valproate during pregnancy increases risk of autism in offspring

Maternal use of valproate (a drug used for the treatment of epilepsy and other neuropsychological disorders) during pregnancy was associated with a significantly increased risk of autism in offspring, according to a study in the April 24 issue of JAMA.

24 Apr 2013

CNIO researcher-led consortium to receive MRA grant to advance research in melanoma

A consortium led by the Spanish National Cancer Research Centre's researcher Mar-a S. Soengas −Programme Director of the Centre-s Molecular Pathology Programme and Leader of the CNIO Melanoma Group− has been selected to receive funding from the Melanoma Research Alliance, the most important private international melanoma research foundation, in order to advance research in melanoma; this type of skin tumour represents one of oncology's biggest challenges due to its high incidence and malignancy.

24 Apr 2013

Drugs News and Research

Malaria approaches must be adjusted to account for local contexts, 'changing realities'

Study: Melatonin delays symptom onset, reduces mortality in mouse model of ALS

U.S. files suit against Novartis in alleged kickback scheme

FDA announces public-private partnership to identify counterfeit anti-malarial medicines with CD-3

WHO highlights threat of antimalarial drug resistance in Greater Mekong subregion

Sofosbuvir is safer than interferon for hepatitis C patients, say scientists

Roundup: Calif. health care cuts attract opponents; Health law means fewer hours for Va. community college instructors

Individuals with MEN1 are at increased risk of developing neuroendocrine tumors

First Edition: April 24, 2013

Researchers decode toggle switch that can stimulate fat burning

South Africa aims to close drug patent loophole that allows for 'ever-greening'

Nanogels to attack lupus: an interview with Dr Look and Dr Fahmy, Yale University

Study identifies malaria parasite protein as potential new target for drug treatment to prevent malaria

Viewpoints: Time to confirm Tavenner; 'Self-defeating' GOP plan for prevention fund; Parents need insurance too

FDA grants orphan-drug designation to XEN402 for treatment of pain associated with EM

BD receives FDA approval for second prefilled injectable drug

Isis Pharmaceuticals starts ISIS-SMNRx Phase 2 study in infants with SMA

PPMI to launch additional study to evaluate multiple potential biomarkers for Parkinson's disease

Maternal use of valproate during pregnancy increases risk of autism in offspring

CNIO researcher-led consortium to receive MRA grant to advance research in melanoma

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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