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EMA grants orphan designation to selumetinib for treatment of neurofibromatosis type 1

AstraZeneca and Merck, known as MSD outside the U.S. and Canada, today announced that the European Medicines Agency (EMA) has granted orphan designation to selumetinib, a MEK 1/2 inhibitor, for the treatment of neurofibromatosis type 1 (NF1).

3 Aug 2018

Monash researchers identify new mechanism used by Henipaviruses in infection

Henipaviruses are among the deadliest viruses known to man and have no effective treatments. The viruses include Hendra, lethal to humans and horses, and the Nipah virus, a serious threat in East and Southeast Asia.

3 Aug 2018

Researchers develop 3D model of human placenta

The placenta is the organ connecting mother and embryo. Its main functions are the exchange of nutrients, gases and metabolic products and the production of hormones and other substances essential for embryonic development.

3 Aug 2018

UW-Madison researcher explores how female fertility is affected by development of the ovary in mice

When Joan Jorgensen was an undergraduate at the University of Wisconsin–Madison, her roommate confided that she had just one period before going through menopause in high school.

3 Aug 2018

Study sheds new light on link between calorie-burning fat and muscle function

Abundant in human babies and small mammals, brown adipose tissue, or brown fat, was only recently discovered in human adults, and its role remains unclear.

3 Aug 2018

Mechanical engineer receives NIH grant to study various aspects of cell group behavior

Researchers have thought that cancer begins when a single cell goes rogue in the body, then begins to grow and multiply.

3 Aug 2018

Map of billion brain cell connections sheds light on how memories are formed and recalled

Scientists have created an elaborate map of more than a billion brain cell connections, helping to shed light on how memories are formed and recalled.

3 Aug 2018

Digestive hormone influences pancreatic cancer growth and spread

A high-fat diet may promote the growth of pancreatic cancer independent of obesity because of the interaction between dietary fat and cholecystokinin, a digestive hormone.

3 Aug 2018

New nuclear medicine test could improve care of patients with type 1 diabetes

Researchers have discovered a new nuclear medicine test that could improve care of patients with type 1 diabetes. The new positron emission tomography imaging method could measure beta-cell mass, which would greatly enhance the ability to monitor and guide diabetes therapies.

3 Aug 2018

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution.

2 Aug 2018

Scientists develop novel peptide drug that could potentially stop development of liver cancer

A research team led by scientists from the Cancer Institute of Singapore at the National University of Singapore has developed a novel peptide drug called FFW that could potentially stop the development of hepatocellular carcinoma or primary liver cancer.

2 Aug 2018

MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

A Massachusetts General Hospital research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma - the second most common bone cancer in children and young adults - unleashes tumor growth.

2 Aug 2018

Study of neuroprotective microRNAs may lead to new avenues for treating tauopathies

Alzheimer's disease is an increasingly prevalent, neurodegenerative condition that erodes memory and other cognitive functions. Treatments for this complex disease have been elusive, although researchers have previously uncovered its main biological features: amyloid-beta plaques and tau tangles.

2 Aug 2018

Researchers use DNA editing tool to reveal mechanisms behind autoimmune diseases

A group of researchers at the University of São Paulo in Brazil used a DNA editing tool called CRISPR/Cas9 to manipulate on of the genes associated to the autoaggressive T lymphocytes responsible for inducing autoimmune diseases such as autoimmune polyglandular syndrome type 1 and type 1 diabetes.

2 Aug 2018

Simple pH imbalance could be a root of Alzheimer’s disease, mouse study shows

Johns Hopkins Medicine scientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer's disease may be a simple imbalance in acid-alkaline - or pH - chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells.

2 Aug 2018

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Regenacy Pharmaceuticals, LLC, a clinical-stage biopharmaceutical company developing breakthrough treatments for diabetic and other peripheral neuropathies, today announced a collaboration with the Charcot-Marie-Tooth Association, a registered non-profit organization serving the hereditary neuropathy patient community, to validate the role of HDAC6 in multiple forms of Charcot-Marie-Tooth disease and evaluate the efficacy of ricolinostat, a selective HDAC6 inhibitor, in animal models.

2 Aug 2018

Rutgers researcher receives $100,000 grant to explore T-cell acute lymphoblastic leukemia

A one-year, $100,000 grant awarded to Rutgers Cancer Institute of New Jersey resident researcher Daniel Herranz Benito, PhD, will support exploration into an aggressive blood cancer that impacts both children and adults – T-cell acute lymphoblastic leukemia.

2 Aug 2018

Mice study shows mother's dengue immunity protects unborn from ZIKA infection

Dengue and Zika viruses are closely related and carried by mosquitos. In infested subtropical and tropical areas, dengue transmission often precedes Zika virus infection, suggesting that women who previously acquired dengue immunity may be bitten by ZIKV-carrying mosquitoes during pregnancy.

2 Aug 2018

Researchers study how herpesviruses contribute to increased oral inflammation

A $2 million grant from the National Institutes of Health will help University of Illinois at Chicago researchers study how herpesviruses, and their underlying molecular mechanisms, contribute to increased inflammation in oral diseases, like periodontitis

2 Aug 2018

New probe allows identification of cancer stem cells in situ

A fluorescent molecular probe that targets cancer stem cells has been developed at the University of Illinois at Urbana-Champaign.

2 Aug 2018

Cell News and Research

EMA grants orphan designation to selumetinib for treatment of neurofibromatosis type 1

Monash researchers identify new mechanism used by Henipaviruses in infection

Researchers develop 3D model of human placenta

UW-Madison researcher explores how female fertility is affected by development of the ovary in mice

Study sheds new light on link between calorie-burning fat and muscle function

Mechanical engineer receives NIH grant to study various aspects of cell group behavior

Map of billion brain cell connections sheds light on how memories are formed and recalled

Digestive hormone influences pancreatic cancer growth and spread

New nuclear medicine test could improve care of patients with type 1 diabetes

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists develop novel peptide drug that could potentially stop development of liver cancer

MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

Study of neuroprotective microRNAs may lead to new avenues for treating tauopathies

Researchers use DNA editing tool to reveal mechanisms behind autoimmune diseases

Simple pH imbalance could be a root of Alzheimer’s disease, mouse study shows

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Rutgers researcher receives $100,000 grant to explore T-cell acute lymphoblastic leukemia

Mice study shows mother's dengue immunity protects unborn from ZIKA infection

Researchers study how herpesviruses contribute to increased oral inflammation

New probe allows identification of cancer stem cells in situ

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