Mouse Model News and Research

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Could a light-listening photonics device detect skin disease? An interview with Prof. Vasilis Ntziachristos

Detection of malignant skin alterations is currently aided by optical microscopes such as dermoscopes or optical microscopes. While the latter offers high resolution, it comes with a major disadvantage, just like any other purely microscopic method: it only provides a partial view of the skin due to the low penetration depth.

29 Aug 2016

NCATS scientists identify promising compounds effective in inhibiting Zika virus replication

Researchers at the National Center for Advancing Translational Sciences recently identified compounds that potentially can be used to inhibit Zika virus replication and reduce its ability to kill brain cells.

29 Aug 2016

Nicotinic receptors could be new therapeutic target to prevent memory loss linked to Alzheimer's

Several scientific studies have indicated that nicotine may be beneficial for memory function.

29 Aug 2016

Novel inhibitory brain receptor reduces seizure-like activity in pubertal mice

More than half of children with epilepsy outgrow their seizures, yet the mechanism underlying this remission is unknown.

26 Aug 2016

Stiff arteries can negatively impact memory and vital brain processes

As we age, our arteries gradually become less flexible, making it harder for the heart to pump blood throughout the body.

26 Aug 2016

Raising brain protein alleviates symptoms of Alzheimer's disease in mouse model

Boosting levels of a specific protein in the brain alleviates hallmark features of Alzheimer's disease in a mouse model of the disorder, according to new research published online August 25, 2016 in Scientific Reports.

25 Aug 2016

Researcher aims to shed new light on inner workings of the retina

One of the more studied parts of the human anatomy, the retina -- the neural layer at the back of the eye that senses light -- still has secrets to reveal.

23 Aug 2016

Injecting omega-3 fatty acid reduces brain damage in neonatal mouse model of stroke

Researchers from Columbia University Medical Center found that omega-3 fatty acids reduced brain damage in a neonatal mouse model of stroke.

23 Aug 2016

Novel marine natural product appears to reduce pancreatic tumor size

Scientists at Florida Atlantic University's Harbor Branch Oceanographic Institute found that a deep-water marine sponge collected off of Fort Lauderdale's coast contains leiodermatolide, a natural product that has the ability to inhibit the growth of cancer cells as well as block cancer cells from dividing using extremely low concentrations of the compound.

18 Aug 2016

Tulane professor receives three-year grant to improve survival of mesenchymal stem cells

Kim O'Connor, a professor in Tulane University's Department of Chemical and Biomolecular Engineering, received a three-year $599,638 grant from the National Science Foundation to study ways to improve the survival of mesenchymal stem cells once they are implanted in patients.

18 Aug 2016

MILabs to provide new hybrid imaging system to Yale for advancing cardiovascular research

MILabs will provide an advanced U-SPECT4CT system to the Yale Translational Research Imaging Center (Y-TRIC) in New Haven-Connecticut, with support of an NIH Shared Instrument Grant for advancing their program in multimodality molecular and translational cardiovascular imaging research.

17 Aug 2016

Modifying huntingtin protein protects against behavioral symptoms in Huntington's model mice

There is new hope in the fight against Huntington's disease. Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

16 Aug 2016

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Before I explain the discovery, I would take a step back and explain an interesting event that takes place in the cancer cells. Normal cells follow a rapid and irreversible process to efficiently eradicate dysfunctional cells. This is a natural process by which damaged cells commit ‘suicide’. This process is known as apoptosis or programmed cell death.

15 Aug 2016

Rare genetic variations linked to severe porphyria

An international research team has linked rare variations in a cell membrane protein to the wide variation in symptom severity that is a hallmark of porphyria, a rare disorder that often affects the skin, liver and nervous system.

10 Aug 2016

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

Patients with sickle cell anemia (SCA) develop heart complications and nearly a quarter die a sudden death. Now, researchers have linked malfunctioning molecular pathways to specific heart anomalies in SCA that result from progressive fibrosis and result in sudden death.

9 Aug 2016

Scientists improve potential weapon to fight against autoimmune disorders

With a trick of engineering, scientists at the Gladstone Institutes improved a potential weapon against inflammation and autoimmune disorders. Their work could one day benefit patients who suffer from inflammatory bowel disease or organ transplant rejection.

9 Aug 2016

Researchers uncover new preventative way to battle against Ascaris roundworm infection

Scientists working out of Trinity College Dublin, Maynooth University, and Queen Mary University of London have unearthed a potential new preventative option to combat Ascaris roundworm infection.

8 Aug 2016

New study shows hedgehog signalling offers protection against colon cancer

Many types of cancer are caused by gene mutations in the signalling pathways that control cell growth, such as the hedgehog signalling pathway.

8 Aug 2016

Research shows alcohol abuse drug inhibits ocular conjunctival scarring in mouse model

New research from University College London, Moorfields Eye Hospital and Duke University School of Medicine has identified a gene that drives scarring, together with a rapidly translatable therapy, for the UK's most common cause of blinding conjunctivitis.

4 Aug 2016

Studies highlight key role for vitamin A metabolite retinoic acid in ocular fibrosis

Mucous membrane pemphigoid is an autoimmune disease that causes inflammation and scarring in mucosal tissues. Affected individuals frequently exhibit scarring in the eye, which can lead to blindness in as many as 20% of patients.

4 Aug 2016

Mouse Model News and Research

Could a light-listening photonics device detect skin disease? An interview with Prof. Vasilis Ntziachristos

NCATS scientists identify promising compounds effective in inhibiting Zika virus replication

Nicotinic receptors could be new therapeutic target to prevent memory loss linked to Alzheimer's

Novel inhibitory brain receptor reduces seizure-like activity in pubertal mice

Stiff arteries can negatively impact memory and vital brain processes

Raising brain protein alleviates symptoms of Alzheimer's disease in mouse model

Researcher aims to shed new light on inner workings of the retina

Injecting omega-3 fatty acid reduces brain damage in neonatal mouse model of stroke

Novel marine natural product appears to reduce pancreatic tumor size

Tulane professor receives three-year grant to improve survival of mesenchymal stem cells

MILabs to provide new hybrid imaging system to Yale for advancing cardiovascular research

Modifying huntingtin protein protects against behavioral symptoms in Huntington's model mice

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Rare genetic variations linked to severe porphyria

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

Scientists improve potential weapon to fight against autoimmune disorders

Researchers uncover new preventative way to battle against Ascaris roundworm infection

New study shows hedgehog signalling offers protection against colon cancer

Research shows alcohol abuse drug inhibits ocular conjunctival scarring in mouse model

Studies highlight key role for vitamin A metabolite retinoic acid in ocular fibrosis

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