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Llama antibodies can detect cerebral lesions that characterize Alzheimer's disease

The major challenge facing physicians treating Alzheimer's is the ability to detect markers of the disease as early as possible. These markers, located in the brain, are difficult to access, hampering diagnosis.

4 Nov 2016

Researchers identify heart defects in progeria patients that may raise risk of arrhythmias, premature death

Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III, working in collaboration with colleagues at other centers in Spain and abroad, have identified defects in the hearts of progeria patients that appear to be related to an elevated risk of arrhythmias and premature death.

2 Nov 2016

Disrupted circadian rhythm may not help achieve maximum weight loss after bariatric surgery

A newly released basic science study of Roux-en-Y gastric bypass (RYGB) suggests that a functioning circadian clock, or sleeping at night and being awake during the day, can help patients achieve a higher amount of weight loss following the surgery.

2 Nov 2016

Turning off TAZ protein in liver cells reverses fibrosis in mice

Scientists at Columbia University Medical Center have identified a factor in liver cells that is responsible for turning a relatively benign liver condition, present in 30 percent of U.S. adults, into a serious disease that can lead to liver failure.

27 Oct 2016

NIH researchers identify novel role for Hsp60 protein in tissue regeneration and wound healing

National Institutes of Health researchers have identified a novel role for a gene known as heat shock protein 60 (Hsp60), finding that it is critical in tissue regeneration and wound healing.

27 Oct 2016

Breakthrough Award supports research on role of chronic stress in breast cancer development

Rutgers Cancer Institute of New Jersey resident research member Wenwei Hu, PhD, has received a $596,250 Breakthrough Award from the U.S. Department of Defense through its Breast Cancer Research Program to study the role of chronic stress in breast cancer development.

25 Oct 2016

Adult brain cells may be vulnerable to Zika infection, new study suggests

Concerns over the Zika virus have focused on pregnant women due to mounting evidence that it causes brain abnormalities in developing fetuses. However, new research in mice from scientists at The Rockefeller University and La Jolla Institute for Allergy and Immunology suggests that certain adult brain cells may be vulnerable to infection as well.

24 Oct 2016

Scientists suggest potential approach of lowering tau levels to thwart Alzheimer's disease

Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer's disease, according to scientists at Baylor College of Medicine, Texas Children's Hospital and Johns Hopkins University School of Medicine.

21 Oct 2016

Yale researchers develop new mouse model to understand multiple myeloma

Understanding how multiple myeloma develops and responds to therapies may be easier using a new mouse model developed at Yale University School of Medicine.

21 Oct 2016

New study raises serious safety concerns in clinical use of caspase inhibitors for liver injury

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase.

20 Oct 2016

Research shows how mitochondrial targeting antioxidants could help treat osteoarthritis

High cholesterol might harm more than our cardiovascular systems. New research using animal models, published online in The FASEB Journal, suggests that high cholesterol levels trigger mitochondrial oxidative stress on cartilage cells, causing them to die, and ultimately leading to the development of osteoarthritis.

17 Oct 2016

Young physician-scientists win Harry Winston Fellowships for innovative pediatric research

Dr. Claire Baldauf, Dr. Marjorie-Anne Guerra and Dr. Manal Habib have been named the recipients of the 2016-2017 Harry Winston Fellowships.

14 Oct 2016

Substance NAD+ can extend life and postpone onset of aging processes

The coenzyme NAD+ plays a main role in aging processes. In mice and roundworm adding the substance can both extend life and postpone the onset of aging processes.

14 Oct 2016

Researchers develop mouse model to investigate behavioral effects of eating disorder gene

Giving mice a gene mutation linked to eating disorders in people causes feeding and behavior abnormalities similar to symptoms often seen in patients with eating disorders. Only female mice are affected by the gene mutation, and some of the abnormalities in the female mice depend on whether they are housed alone or together with other mice.

13 Oct 2016

New study unravels cause of cognitive loss in tauopathy disorders

Tauopathies are a group of neurodegenerative disorders, including Alzheimer's disease that are characterized by the deposition of aggregates of the tau protein inside brain cells.

13 Oct 2016

Visual cortex plays key role in promoting plasticity of innate, spontaneous eye movements

By peering into the eyes of mice and tracking their ocular movements, researchers made an unexpected discovery: the visual cortex - a region of the brain known to process sensory information - plays a key role in promoting the plasticity of innate, spontaneous eye movements.

13 Oct 2016

New research reveals key protein involved in heart failure

A key protein that causes heart failure has been revealed through new research from a collaboration based in Kumamoto University, Japan.

13 Oct 2016

Study identifies mechanistic link between maternal obesity and childhood hypertension

Exposure of babies to high levels of the 'fullness' hormone, leptin, in the womb irreversibly activates receptors in the brain that regulate blood pressure, according to a new study by researchers from King's College London, part-funded by the British Heart Foundation.

12 Oct 2016

Common food-poisoning bacteria linked to increased risk of Crohn's disease

People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn's disease later in life, according to a new study led by researchers at McMaster University.

7 Oct 2016

Researchers explain why explain why some tumors recur after immunotherapy

Immunotherapy is a new and highly promising form of treatment for cancer. In many patients, however, tumors recur after immunotherapy.

7 Oct 2016

Mouse Model News and Research

Llama antibodies can detect cerebral lesions that characterize Alzheimer's disease

Researchers identify heart defects in progeria patients that may raise risk of arrhythmias, premature death

Disrupted circadian rhythm may not help achieve maximum weight loss after bariatric surgery

Turning off TAZ protein in liver cells reverses fibrosis in mice

NIH researchers identify novel role for Hsp60 protein in tissue regeneration and wound healing

Breakthrough Award supports research on role of chronic stress in breast cancer development

Adult brain cells may be vulnerable to Zika infection, new study suggests

Scientists suggest potential approach of lowering tau levels to thwart Alzheimer's disease

Yale researchers develop new mouse model to understand multiple myeloma

New study raises serious safety concerns in clinical use of caspase inhibitors for liver injury

Research shows how mitochondrial targeting antioxidants could help treat osteoarthritis

Young physician-scientists win Harry Winston Fellowships for innovative pediatric research

Substance NAD+ can extend life and postpone onset of aging processes

Researchers develop mouse model to investigate behavioral effects of eating disorder gene

New study unravels cause of cognitive loss in tauopathy disorders

Visual cortex plays key role in promoting plasticity of innate, spontaneous eye movements

New research reveals key protein involved in heart failure

Study identifies mechanistic link between maternal obesity and childhood hypertension

Common food-poisoning bacteria linked to increased risk of Crohn's disease

Researchers explain why explain why some tumors recur after immunotherapy

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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