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Researchers provide insights into potential therapeutic approaches to Down syndrome

University of Michigan researchers have determined how a gene that is known to be defective in Down syndrome is regulated and how its dysregulation may lead to neurological defects, providing insights into potential therapeutic approaches to an aspect of the syndrome.

6 Jun 2013

New research suggests that surgical anesthesia may also have lasting effects on adult brains

As pediatric specialists become increasingly aware that surgical anesthesia may have lasting effects on the developing brains of young children, new research suggests the threat may also apply to adult brains.

6 Jun 2013

Research demonstrates need for development of new treatments for regeneration of nerve cells

Researchers at the University of Michigan have evidence that a single gene controls both halves of nerve cells, and their research demonstrates the need to consider that design in the development of new treatments for regeneration of nerve cells.

5 Jun 2013

Research: RG3039 drug can extend survival, improve function in spinal muscular atrophy mouse models

In a new publication that appears in Human Molecular Genetics, the laboratory of Christine DiDonato, PhD reports on their pharmacological characterization of the drug RG3039, demonstrating that it can extend survival and improve function in two spinal muscular atrophy (SMA) mouse models.

5 Jun 2013

Canadian researcher develops first animal model to study function of C9ORF72 in ALS

Canadian researcher Edor Kabashi of the Université de Montréal has developed the first animal model to study the function of a gene responsible for the highest percentage of ALS, commonly known as Lou Gehrig's disease. Results to date shed light on the cause of the devastating disease.

4 Jun 2013

People with narcolepsy have increased number of neurons that produce histamine

A new study provides surprising evidence that people with narcolepsy have an increased number of neurons that produce histamine, suggesting that histamine signaling may be a novel therapeutic target for this potentially disabling sleep disorder.

4 Jun 2013

Study points to synergistic relationship between lead exposure and schizophrenia gene

Mice engineered with a human gene for schizophrenia and exposed to lead during early life exhibited behaviors and structural changes in their brains consistent with schizophrenia.

1 Jun 2013

Researchers tie traumatic brain injury to toxic form of protein

University of Texas Medical Branch at Galveston researchers have uncovered what may be a key molecular mechanism behind the lasting damage done by traumatic brain injury.

30 May 2013

Protein presenilin plays critical role in controlling neuronal traffic on microtubule highways

Imagine if you could open up your brain and look inside. What you would see is a network of nerve cells called neurons, each with its own internal highway system for transporting essential materials between different parts of the cell.

29 May 2013

IUPUI assistant professor earns NSF CAREER Award for research on the brain

An assistant professor of computer science at Indiana University-Purdue University Indianapolis has earned the prestigious CAREER Award from the National Science Foundation for research to identify the patterns by which neurons develop and connect to form a brain.

29 May 2013

Transplantation of human stem cells improves muscle function in rats used to model ALS

Transplantation of human stem cells in an experiment conducted at the University of Wisconsin-Madison improved survival and muscle function in rats used to model ALS, a nerve disease that destroys nerve control of muscles, causing death by respiratory failure.

29 May 2013

Research discovery may lead to development of new therapies for neurological disorders

For several years, the pharmaceutical industry has tried to develop drugs that target a specific neurotransmitter receptor in the brain, the NMDA receptor. This receptor is present on almost every neuron in the human brain and is involved in learning and memory. NMDA receptors also have been implicated in several neurological and psychiatric conditions such as Alzheimer's disease, Parkinson's disease, schizophrenia and depression.

29 May 2013

Single injection of human neural stem cells improves acute spinal cord injuries in rats

An international team led by researchers at the University of California, San Diego School of Medicine reports that a single injection of human neural stem cells produced neuronal regeneration and improvement of function and mobility in rats impaired by an acute spinal cord injury.

28 May 2013

Scientists question strategy to target critical protein in the brain to combat Alzheimer's disease

In the search for medication against Alzheimer's disease, scientists have focused - among other factors - on drugs that can break down Amyloid beta (A-beta). After all, it is the accumulation of A-beta that causes the known plaques in the brains of Alzheimer's patients. Starting point for the formation of A-beta is APP. Alessia Soldano and Bassem Hassan (VIB/KU Leuven) were the first to unravel the function of APPL - the fruit-fly version of APP - in the brain of healthy fruit flies.

28 May 2013

Neuroscientists identify key circuit elements that contribute to everyday decision in ACC

You are sitting on your couch flipping through TV channels trying to decide whether to stay put or get up for a snack. Such everyday decisions about whether to "stay" or to "go" are supported by a brain region called the anterior cingulate cortex (ACC), which is part of the prefrontal cortex.

27 May 2013

Researchers identify mutations in new genes that might be associated with ALS disease

Researchers at the Stanford University School of Medicine have identified mutations in several new genes that might be associated with the development of spontaneously occurring cases of the neurodegenerative disease known as amyotrophic lateral sclerosis, or ALS.

27 May 2013

Calyx of Held: The largest synapse could shed light on neuropsychiatric disorders

Humans and most mammals can determine the spatial origin of sounds with remarkable acuity. We use this ability all the time -- crossing the street; locating an invisible ringing cell phone in a cluttered bedroom.

27 May 2013

Researchers reveal new insights about the process of axon amputation

As the human body fine-tunes its neurological wiring, nerve cells often must fix a faulty connection by amputating an axon - the "business end" of the neuron that sends electrical impulses to tissues or other neurons. It is a dance with death, however, because the molecular poison the neuron deploys to sever an axon could, if uncontained, kill the entire cell.

24 May 2013

Cinnamon compounds show some promise in the effort to fight Alzheimer's disease

Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important benefit? The common baking spice might hold the key to delaying the onset of -- or warding off -- the effects of Alzheimer's disease.

24 May 2013

Discovery could aid research into motor neuron disease

Scientists have found that a key hormone allows young zebrafish to develop and replace their motor neurons - a kind of nerve cell found in the spinal cord.

24 May 2013

Neuron News and Research

Researchers provide insights into potential therapeutic approaches to Down syndrome

New research suggests that surgical anesthesia may also have lasting effects on adult brains

Research demonstrates need for development of new treatments for regeneration of nerve cells

Research: RG3039 drug can extend survival, improve function in spinal muscular atrophy mouse models

Canadian researcher develops first animal model to study function of C9ORF72 in ALS

People with narcolepsy have increased number of neurons that produce histamine

Study points to synergistic relationship between lead exposure and schizophrenia gene

Researchers tie traumatic brain injury to toxic form of protein

Protein presenilin plays critical role in controlling neuronal traffic on microtubule highways

IUPUI assistant professor earns NSF CAREER Award for research on the brain

Transplantation of human stem cells improves muscle function in rats used to model ALS

Research discovery may lead to development of new therapies for neurological disorders

Single injection of human neural stem cells improves acute spinal cord injuries in rats

Scientists question strategy to target critical protein in the brain to combat Alzheimer's disease

Neuroscientists identify key circuit elements that contribute to everyday decision in ACC

Researchers identify mutations in new genes that might be associated with ALS disease

Calyx of Held: The largest synapse could shed light on neuropsychiatric disorders

Researchers reveal new insights about the process of axon amputation

Cinnamon compounds show some promise in the effort to fight Alzheimer's disease

Discovery could aid research into motor neuron disease

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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