Infectious Diseases News and Research

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Investigational vaccine does not provide sufficient protection against HIV infection

An investigational HIV vaccine tested in the "Imbokodo" clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data. The Phase 2b proof-of-concept study, which began in November 2017, enrolled 2,637 women ages 18 to 35 years from five countries.

31 Aug 2021

Coronavirus buildup in the lungs is likely behind high mortality rates

A buildup of coronavirus in the lungs is likely behind the steep mortality rates seen in the pandemic, a new study finds.

31 Aug 2021

Study compares risk of hospitalization from SARS-CoV-2 delta and alpha variants

Largest study to date analyzing more than 40,000 COVID-19 cases (including a combination of vaccinated and unvaccinated individuals) confirmed by virus genome sequencing finds a two-fold increased risk of hospitalization from delta versus alpha variant infections.

31 Aug 2021

The tale of mRNA vaccines: Turning calamity into opportunity

In a review paper published in the journal Nature Reviews, researchers from Carnegie Mellon University and the University of Pennsylvania have described the underlying technologies for mRNA vaccines and their future prospects with improved delivery systems and applications in diseases beyond the ongoing COVID-19 pandemic.

31 Aug 2021

Monoclonal antibody treatment combo can reduce the impact of COVID-19 in high-risk patients

In an observational study, Mayo Clinic researchers report that the combination of casirivimab and imdevimab - two monoclonal antibody treatments under Food and Drug Administration emergency use authorization - keep high-risk patients out of the hospital when infected with mild to moderate COVID-19. The findings appear in The Lancet's EClinicalMedicine.

31 Aug 2021

New study to investigate treatment of respiratory infections in children with tracheostomy

Each year, approximately 4,000 children undergo a tracheostomy- the surgical placement of a breathing tube-due to respiratory or neuromuscular disorders or chronic disease progression.

30 Aug 2021

Researchers study the role of low-density granulocytes in COVID-19

Information on granulocytes helps to understand mechanisms associated with covid-19 and other infectious diseases. Such information also promotes the development of better diagnostic methods and therapies.

30 Aug 2021

Concert venues are banking on proof of vaccines or negative tests to woo back fans

Fans of the band Wilco could have reasonably interpreted frontman Jeff Tweedy singing "I Am Trying to Break Your Heart" at an Aug. 13 concert at St. Louis Music Park as the universe explaining the past year or so.

30 Aug 2021

CoronaVac elicits lower antibody response than natural SARS-CoV-2 infection, study suggests

A recent study from Thailand highlights a rather low degree of neutralization-afforded protection mounted by the inactivated whole-virus CoronaVac vaccine compared to natural infection with SARS-CoV-2 – the virus that causes COVID-19.

30 Aug 2021

Study reveals measures to tackle musical COVID-19 transmission

As the COVID-19 pandemic swept the globe in 2020, musicians around the world were desperate for the answers to two pressing questions: Can playing musical instruments transmit COVID-19? And if so, what can be done?

28 Aug 2021

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

The National Institutes of Health has begun a clinical trial to assess the antibody response to an extra dose of an authorized or approved COVID-19 vaccine in people with autoimmune disease who did not respond to an original COVID-19 vaccine regimen.

27 Aug 2021

States pull back on covid data even amid delta surge

Two state government websites in Georgia recently stopped posting updates on covid-19 cases in prisons and long-term care facilities, just as the dangerous delta variant was taking hold.

27 Aug 2021

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

The AIDS Clinical Trials Group, the largest global HIV research network, which has expanded its focus to include evaluating outpatient treatment for COVID-19, today announced positive data for the monoclonal antibody combination therapy BRII-196/BRII-198 from the ACTIV-2 study of Outpatient Monoclonal Antibodies and Other Therapies.

27 Aug 2021

Pediatric cancer patients fare worse with COVID-19 than children without cancer

Research from a large international effort shows that 20% of children with cancer who are infected with SARS-CoV-2 develop severe infections.

27 Aug 2021

What Missouri learned the hard way about rapid covid testing in schools

Early in the tumultuous 2020-21 school year, Missouri officials made a big gamble: set aside roughly 1 million rapid covid tests for the state's K-12 schools in hopes of quickly identifying sick students or staff members.

26 Aug 2021

New Montana law sows confusion, defiance over school quarantines

As classes get underway this week and next, Montana school and county health officials are grappling with how a new state law that bans vaccine discrimination should apply to quarantine orders for students and staffers exposed to covid-19.

26 Aug 2021

Study provides new insight into the mosquito immune system and disease transmission

A new study that details mosquito immune cells could shed light on the insect immune system and how mosquitoes transmit parasites that cause malaria.

25 Aug 2021

Study: Majority of hospital-acquired COVID-19 cases were contracted from other patients

The majority of patients who contracted COVID-19 while in the hospital did so from other patients rather than from healthcare workers, concludes a new study from researchers at the University of Cambridge and Addenbrooke's Hospital.

25 Aug 2021

Researchers find clues to how lung damage develops in the aftermath of a respiratory infection

The deadliest time in a viral respiratory illness sometimes is actually after the virus is cleared from the body. Destructive processes that are set in motion during an infection crest in the weeks after the virus is defeated, leading to organ damage that can cause chronic illness or even death.

24 Aug 2021

Atomic-level imaging of infectious prions reveals new therapeutic targets for untreatable diseases

The highest-ever resolution imaging of an infectious prion provides the first atomic-level data of how these abnormal proteins are assembled to cause fatal neurodegenerative diseases in people and animals - and how they can be potentially targeted by new therapies.

24 Aug 2021

Infectious Diseases News and Research

Investigational vaccine does not provide sufficient protection against HIV infection

Coronavirus buildup in the lungs is likely behind high mortality rates

Study compares risk of hospitalization from SARS-CoV-2 delta and alpha variants

The tale of mRNA vaccines: Turning calamity into opportunity

Monoclonal antibody treatment combo can reduce the impact of COVID-19 in high-risk patients

New study to investigate treatment of respiratory infections in children with tracheostomy

Researchers study the role of low-density granulocytes in COVID-19

Concert venues are banking on proof of vaccines or negative tests to woo back fans

CoronaVac elicits lower antibody response than natural SARS-CoV-2 infection, study suggests

Study reveals measures to tackle musical COVID-19 transmission

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

States pull back on covid data even amid delta surge

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

Pediatric cancer patients fare worse with COVID-19 than children without cancer

What Missouri learned the hard way about rapid covid testing in schools

New Montana law sows confusion, defiance over school quarantines

Study provides new insight into the mosquito immune system and disease transmission

Study: Majority of hospital-acquired COVID-19 cases were contracted from other patients

Researchers find clues to how lung damage develops in the aftermath of a respiratory infection

Atomic-level imaging of infectious prions reveals new therapeutic targets for untreatable diseases

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