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Cangrelor more effective than clopidogrel in preventing blood clots

A new and experimental anti-clotting drug, cangrelor, proved better than the commonly used clopidogrel and was significantly more effective at preventing blood clots in a large trial of patients who underwent coronary stent procedures.

12 Mar 2013

Laboratory for Molecular Biodiscovery, KU Leuven partner for €9.5M 'PharmaSea' project

KU Leuven scientist Camila Esguerra and the Laboratory for Molecular Biodiscovery are coordinating a €9.5 million, EU-funded project to collect and study marine microbes extracted from some of the ocean's deepest, most extreme - and as-yet-unexplored -biomes.

12 Mar 2013

Health officials worried MDR-TB will become more common worldwide, in U.S.

The case of a Nepalese man with extensively drug-resistant tuberculosis (XDR-TB) traveling through 13 countries before illegally entering the U.S. from Mexico, "first described by Betsy McKay at the Wall Street Journal, provides a window on a problem that health officials say is sure to arise more and more often," NPR's "Shots" blog reports.

12 Mar 2013

Anti-cancer drug conjugates: an interview with Dr Andreas Menrad, CSO Ablynx and Dr Chris Martin, CEO Spirogen

Antibodies and in the case of Ablynx, Nanobodies, can be raised and selected to bind with high affinity selectively to cancer cells in a tumour. Cancer cells are exquisitely sensitive to certain toxins such as the PBDs produced by Spirogen.

12 Mar 2013

Results from Orion Pharma’s ORM-12741 phase IIa study on AD

A new drug may improve memory problems in people with moderate Alzheimer's disease, according to a phase IIa study released today that will be presented at the American Academy of Neurology's 65th Annual Meeting in San Diego, March 16 to 23, 2013. The drug is called ORM-12741.

12 Mar 2013

NIH-sponsored comparative trial evaluates benefits of combination therapy and monotherapy in MS

People with multiple sclerosis (MS) who were treated with combination therapy did not see significant clinical benefit over those treated with single drug therapy, but combination therapy did reduce the development of new lesions, according to an international research team led by The Mount Sinai Medical Center.

12 Mar 2013

$Sildenafil does not improve exercise capacity in HF patients with preserved ejection fraction$

Sildenafil does not improve exercise capacity in HF patients with preserved ejection fraction

Among patients with heart failure with preserved ejection fraction (a measure of heart function), administration of sildenafil for 24 weeks, compared with placebo, did not result in significant improvement in exercise capacity or clinical status, according to a study published online by JAMA.

12 Mar 2013

Patients with neck injuries incur increased health and social costs

Patients with neck injuries incur increased health and social costs-which also affect their spouses and may begin years before the initial injury, reports a study in the March 1 issue of Spine.

12 Mar 2013

Combination of INF and glatiramer acetate does not reduce MS progression

A recent clinical trial found that interferonβ-1a (INF) and glatiramer acetate (GA), two of the most commonly prescribed drugs for multiple sclerosis (MS), provide no additional clinical benefit when taken together.

12 Mar 2013

Pitavastatin may reduce risk of heart attack, stroke and death in patients with high cholesterol

Heart patients who can't tolerate the side effects of cholesterol-lowering drugs may have a new option, according to a new study by researchers from the Intermountain Heart Institute at Intermountain Medical Center in Salt Lake City.

12 Mar 2013

Buphenyl may protect memory and prevent progression of Alzheimer's

Buphenyl, an FDA-approved medication for hyperammonemia, may protect memory and prevent the progression of Alzheimer's disease.

12 Mar 2013

Cell phone microscope can detect intestinal worm infections in children

Scientists working in rural Tanzania have used a simple US$8 glass lens, a strip of double-sided tape, and a cheap flashlight to convert an Apple iPhone into a field microscope that can successfully detect intestinal worm infections in children, according to a study published online today by the American Journal of Tropical Medicine and Hygiene.

12 Mar 2013

Sanford-Burnham, Mayo Clinic partner to expand and speed development of new drugs

To expand and speed the development of new drugs for its patients, Mayo Clinic has entered a formal collaboration with Sanford-Burnham Medical Research Institute. Under the agreement, Mayo's discoveries of potential drug targets will be the basis for the development of new drug screening platforms. This will allow future work that focuses on high-throughput screening and medicinal chemistry at Sanford-Burnham facilities.

12 Mar 2013

Antipsychotic drugs associated with increased risk of stroke in the elderly

Antipsychotic administration in the elderly is associated with an increased risk for cerebrovascular accident, more commonly known as stroke; a new study published in Biological Psychiatry provides additional insight into this important relationship.

12 Mar 2013

Viewpoints: 5 lies about entitlements; Obama's plans for Medicare still not clear; Generic drug makers need to be accountable

So here's a list with a bit more gravitas: The five biggest lies you're being told about entitlement programs. Never mind that the very word "entitlement" is a lie. Social Security and Medicare got that name because workers became "entitled" to those benefits by paying into the system. In recent years, however, the term has become distorted to signify benefits people are entitled to without earning them. Leaving that whopper aside, here are the top five.

12 Mar 2013

Researchers develop new approach to screening potential treatments for Alzheimer's disease

According to a 2012 World Health Organization report, over 35 million people worldwide currently have dementia, a number that is expected to double by 2030 (66 million) and triple by 2050 (115 million).

11 Mar 2013

Influenza drug: an interview with Dr Jenny McKimm-Breschkin, CSIRO

Influenza or flu for short is caused by a family of viruses, which can be called influenza A or influenza B. Influenza A viruses are found in humans, animals – like swine and horses- and mostly aquatic birds. Influenza B is only found in humans.

11 Mar 2013

SDF-1 turns on autophagy that helps cells stay in place and focused on making bone

A signaling molecule that helps stem cells survive in the naturally low-oxygen environment inside the bone marrow may hold clues to helping the cells survive when the going gets worse with age and disease, researchers report.

11 Mar 2013

UT Southwestern researcher to receive March of Dimes Prize in Developmental Biology

Dr. Eric Olson, chairman of molecular biology at UT Southwestern Medical Center, is the 2013 recipient of the March of Dimes Prize in Developmental Biology for identifying key genetic pathways in the formation of the heart and other muscles.

11 Mar 2013

FDA accepts Ampio’s Patient Outcome for Premature Ejaculation questionnaire

Ampio Pharmaceuticals, Inc., a biopharmaceutical company developing drugs to treat prevalent inflammatory diseases, such as osteoarthritis (Ampion) and diabetic macular edema (Optina) and sexual dysfunction (Zertane) announced FDA acceptance of its POPE questionnaire, a modification of the Premature Ejaculation Profile (PEP) questionnaire that was used in the two successful Zertane Phase 3 clinical trials completed in Europe.

11 Mar 2013

Drugs News and Research

Cangrelor more effective than clopidogrel in preventing blood clots

Laboratory for Molecular Biodiscovery, KU Leuven partner for €9.5M 'PharmaSea' project

Health officials worried MDR-TB will become more common worldwide, in U.S.

Anti-cancer drug conjugates: an interview with Dr Andreas Menrad, CSO Ablynx and Dr Chris Martin, CEO Spirogen

Results from Orion Pharma’s ORM-12741 phase IIa study on AD

NIH-sponsored comparative trial evaluates benefits of combination therapy and monotherapy in MS

Sildenafil does not improve exercise capacity in HF patients with preserved ejection fraction

Patients with neck injuries incur increased health and social costs

Combination of INF and glatiramer acetate does not reduce MS progression

Pitavastatin may reduce risk of heart attack, stroke and death in patients with high cholesterol

Buphenyl may protect memory and prevent progression of Alzheimer's

Cell phone microscope can detect intestinal worm infections in children

Sanford-Burnham, Mayo Clinic partner to expand and speed development of new drugs

Antipsychotic drugs associated with increased risk of stroke in the elderly

Viewpoints: 5 lies about entitlements; Obama's plans for Medicare still not clear; Generic drug makers need to be accountable

Researchers develop new approach to screening potential treatments for Alzheimer's disease

Influenza drug: an interview with Dr Jenny McKimm-Breschkin, CSIRO

SDF-1 turns on autophagy that helps cells stay in place and focused on making bone

UT Southwestern researcher to receive March of Dimes Prize in Developmental Biology

FDA accepts Ampio’s Patient Outcome for Premature Ejaculation questionnaire

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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