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Combining mitochondrial inhibitors could improve efficacy of BRAF inhibitors in melanoma

A multi-institutional study has revealed that BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism.

11 Mar 2013

IP chemotherapy increases survival in patients with advanced ovarian cancer

Patients with advanced ovarian cancer who undergo intensive treatment with chemotherapy that bathes the abdomen are significantly more likely to live longer than those who receive standard intravenous (IV) chemotherapy, according to a study that analyzed long-term follow-up from two landmark Gynecologic Oncology Group (GOG) trials comprising 876 patients.

11 Mar 2013

NCI-sponsored study to evaluate rosuvastatin for prevention of colon cancer

With March designated as Colorectal Cancer Awareness Month, the North Shore-LIJ Cancer Institute is enrolling people who were recently treated for colon cancer in a polyp prevention study. This National Cancer Institute (NCI)-sponsored study evaluates the cholesterol drug, rosuvastatin (Crestor), as a treatment to reduce the risk of colon cancer.

11 Mar 2013

Aarbepoetin alfa does not improve anemic heart failure patients' health

Researchers from Cleveland Clinic and Sweden-based Sahlgrenska University Hospital have found that a commonly used drug to treat anemia in heart failure patients -darbepoetin alfa - does not improve patients' health, nor does it reduce their risk of death from heart failure.

11 Mar 2013

Einstein researchers to develop drug-impregnated intravaginal ring for HIV prevention in women

Researchers at Albert Einstein College of Medicine of Yeshiva University have been awarded a $12 million grant from the National Institutes of Health (NIH) to develop a drug-impregnated intravaginal ring to prevent HIV infection in women.

11 Mar 2013

Armetheon plans to develop tecarfarin against prosthetic heart valves or chronic renal dysfunction

Armetheon, Inc., a clinical stage biopharmaceutical company, announced today that it plans to develop its novel oral anti-coagulant (OAC), tecarfarin (ATI-5923), for a patient population which includes those who have prosthetic heart valves or chronic renal dysfunction.

11 Mar 2013

Drugs that combat ageing may be available within five years

Drugs that combat ageing may be available within five years, following landmark work led by an Australian researcher.

11 Mar 2013

Addiction risk increased after mild traumatic brain injury

A study of military personnel suggests that individuals who have suffered a mild traumatic brain injury are at increased for addiction-related disorders.

8 Mar 2013

Researchers uncover cellular-level detail of what happens when bone bears stress over time

From athletes to individuals suffering from osteoporosis, bone fractures are usually the result of tiny cracks accumulating over time -- invisible rivulets of damage that, when coalesced, lead to that painful break.

8 Mar 2013

Patients with drug-resistant HIV can safely achieve viral suppression without NRTIs

A new multi-site study reveals patients with drug-resistant HIV can safely achieve viral suppression - the primary goal of HIV therapy - without incorporating the traditional class of HIV medications into their treatment regimen.

8 Mar 2013

Media coverage of 'functional cure' in baby born with HIV continues

Highlighting the recent case of an infant reportedly cured of HIV infection "after a swiftly administered course of drugs," Scientific American writes, "A number of factors make the child's case unique, ... and clinicians caution that we have not discovered a general cure for HIV yet. Still, the medical first may hint at ways to fight the AIDS-causing virus."

8 Mar 2013

Editorial, opinion pieces react to 'functional cure' of infant born with HIV

Scientists on Sunday announced that an infant born with HIV appears to have been "functionally cured" of the virus after receiving antiretroviral therapy (ART) within 30 hours of birth.

8 Mar 2013

Study shows reduction of brain capillaries in mice immunized with amyloid beta

University of British Columbia researchers have successfully normalized the production of blood vessels in the brain of mice with Alzheimer's disease (AD) by immunizing them with amyloid beta, a protein widely associated with the disease.

8 Mar 2013

'Science Speaks' blog reports from 20th Conference on Retroviruses and Opportunistic Infections

The Center for Global Health Policy's "Science Speaks" blog on Wednesday published a series of posts on the 20th Conference on Retroviruses and Opportunistic Infections (CROI), which took place in Atlanta, Georgia, from Sunday to Wednesday.

8 Mar 2013

Novel drug seems to increase effectiveness of usual chemotherapy against IBC

Researchers in the University of Delaware's Department of Biological Sciences are investigating a new drug that has shown positive results in early tests of its ability to fight a rare and aggressive form of breast cancer.

8 Mar 2013

TV ads may drive over-diagnosis of high cholesterol and over-treatment with statins

Television advertising may drive over-diagnosis of high cholesterol and over-treatment with statins, according to a new study¹ by Dr. Jeff Niederdeppe from Cornell University in the US and colleagues. It appears that a trip to the doctor enquiring about statins advertised on TV often leads to a prescription.

8 Mar 2013

African-American women with breast cancer more likely to develop heart failure

African-American women who survive breast cancer are more likely to develop heart failure than other women who have beaten the disease, according to research being presented at the American College of Cardiology's 62nd Annual Scientific Session.

8 Mar 2013

Melittin-loaded nanoparticles can destroy human immunodeficiency virus

Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding cells unharmed, researchers at Washington University School of Medicine in St. Louis have shown.

8 Mar 2013

UNMC provides important genetic tool for scientists to better utilize library of mutant staph bacteria

Through the creation of a library of more than 2,000 mutant strains of the Staphylococcus aureus bacteria, the University of Nebraska Medical Center has provided an important tool for scientists around the world seeking answers for how to better deal with staph infections.

8 Mar 2013

Nearly 90% of young children continue to struggle with ADHD symptoms despite treatment

A study published in the March 2013 issue of the Journal of the American Academy of Child and Adolescent Psychiatry found that 9 out of 10 young children with moderate to severe attention-deficit/hyperactivity disorder (ADHD) continue to experience serious to severe symptoms and impairment long after their original diagnoses, and in many cases, despite treatment.

8 Mar 2013

Drugs News and Research

Combining mitochondrial inhibitors could improve efficacy of BRAF inhibitors in melanoma

IP chemotherapy increases survival in patients with advanced ovarian cancer

NCI-sponsored study to evaluate rosuvastatin for prevention of colon cancer

Aarbepoetin alfa does not improve anemic heart failure patients' health

Einstein researchers to develop drug-impregnated intravaginal ring for HIV prevention in women

Armetheon plans to develop tecarfarin against prosthetic heart valves or chronic renal dysfunction

Drugs that combat ageing may be available within five years

Addiction risk increased after mild traumatic brain injury

Researchers uncover cellular-level detail of what happens when bone bears stress over time

Patients with drug-resistant HIV can safely achieve viral suppression without NRTIs

Media coverage of 'functional cure' in baby born with HIV continues

Editorial, opinion pieces react to 'functional cure' of infant born with HIV

Study shows reduction of brain capillaries in mice immunized with amyloid beta

'Science Speaks' blog reports from 20th Conference on Retroviruses and Opportunistic Infections

Novel drug seems to increase effectiveness of usual chemotherapy against IBC

TV ads may drive over-diagnosis of high cholesterol and over-treatment with statins

African-American women with breast cancer more likely to develop heart failure

Melittin-loaded nanoparticles can destroy human immunodeficiency virus

UNMC provides important genetic tool for scientists to better utilize library of mutant staph bacteria

Nearly 90% of young children continue to struggle with ADHD symptoms despite treatment

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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