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Study finds how to shut down Bcl6 in diffuse large B-cell lymphoma

The powerful master regulatory transcription factor called Bcl6 is key to the survival of a majority of aggressive lymphomas, which arise from the B-cells of the immune system. The protein has long been considered too complex to target with a drug since it is also crucial to the healthy functioning of many immune cells in the body, not just B cells gone bad.

4 Mar 2013

Researchers identify mechanisms that connect variety of diseases linked with inflammation

A study led by researchers at Boston University School of Medicine (BUSM) has identified epigenetic mechanisms that connect a variety of diseases associated with inflammation.

3 Mar 2013

Global inhibition of all Notch signals would not be safe after bone marrow transplantation

Bone marrow transplant is a key treatment for patients with leukemia, lymphoma, multiple myeloma and other blood disorders. University of Michigan researchers have discovered that inhibiting a signaling pathway in some of the transplanted cells could prevent the most serious potential complications of the procedure, a conflict between the transplanted cells and the recipient's own tissue called graft-versus-host disease.

2 Mar 2013

Report: Drug companies spent $84M marketing pharmaceuticals in the District of Columbia in 2011

Drug companies spent nearly $84 million marketing pharmaceuticals in the District of Columbia in 2011, including an outlay of nearly $19 million for gifts given to physicians, hospitals and other health care providers, according to a report by researchers at the George Washington University School of Public Health and Health Services.

2 Mar 2013

Measles epidemic affecting tens of thousands of children in DRC, MSF warns

"A measles epidemic has affected tens of thousands of children in northern Democratic Republic of Congo (DRC), overwhelming health facilities, says medical charity Médecins Sans Frontières (MSF)," IRIN reports.

2 Mar 2013

Cannabis can be detected in blood of chronic daily smokers for a month after last intake

New research appearing online today in Clinical Chemistry, the journal of AACC, shows that cannabis can be detected in the blood of daily smokers for a month after last intake.

2 Mar 2013

Study shows triple-negative breast cancer cells missing key enzyme

A groundbreaking new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain - providing insight into potential therapeutic targets to treat the aggressive cancer.

2 Mar 2013

$Bisphosphonate link to nonhealing fractures strengthened$

Bisphosphonate link to nonhealing fractures strengthened

US scientists have identified a safety signal between bisphosphonate use and nonhealing femoral fractures, possibly due to the rare side effect, atypical femur fracture.

1 Mar 2013

GlaxoSmithKline's HIV/AIDS business joins Medicines Patent Pool

"GlaxoSmithKline's HIV/AIDS drugs business is to share intellectual property rights on children's medicine in a patent pool designed to make treatments more widely available in poor countries," Reuters reports.

1 Mar 2013

Study shows how theranostic nanoparticles can effectively deliver cancer drugs to tumour cells

Tiny particles filled with a drug could be a new tool for treating cancer in the future. A new study published by Swedish scientists in Particle & Particle Systems Characterization shows how such nanoparticles can be combined to secure the effective delivery of cancer drugs to tumour cells - and how they can be given properties to make them visible in MR scanners and thus rendered trackable.

1 Mar 2013

Pivotal study of olesoxime in Spinal Muscular Atrophy receives positive interim review

Trophos SA, a clinical stage pharmaceutical company developing innovative therapeutics from discovery to clinical validation for under-served medical needs in neurology and cardiology, announced the completion of the interim analysis of the pivotal efficacy study of olesoxime in the rare neurodegenerative condition Spinal Muscular Atrophy (SMA).

1 Mar 2013

Urea cycle disorder patient successfully treated by Promethera(R) HepaStem in Phase I/II trial in France

Promethera Biosciences, a Belgian biotechnology company developing Promethera(R) HepaStem, a cell-based therapy for the treatment of liver-based metabolic diseases including Crigler-Najjar Syndrome and Urea Cycle Disorders, announced that it has successfully treated a patient with liver progenitor cells enrolled in its Phase I/II trial.

1 Mar 2013

Scientists take important step toward designing a uniform protocol for microbiome research

Earth Day may be more than a month away, but another, more personal, ecosystem has been shown to also be worth protecting-within our bodies are communities of microbes that affect the behavior of human cells hosting them.

1 Mar 2013

Not all acne bacteria trigger pimples: Study

The bacteria that cause acne live on everyone's skin, yet one in five people is lucky enough to develop only an occasional pimple over a lifetime.

1 Mar 2013

Researchers develop new method to study complex molecular workings of Anopheles albimanus

Researchers at the Johns Hopkins Malaria Research Institute have developed a new method for studying the complex molecular workings of Anopheles albimanus, an important but less studied spreader of human malaria.

1 Mar 2013

Otsuka receives FDA approval for ABILIFY MAINTENA to treat schizophrenia

Otsuka Pharmaceutical Co., Ltd. (Otsuka) and H. Lundbeck A/S (Lundbeck) announced the U.S. Food and Drug Administration (FDA) has approved ABILIFY MAINTENA (aripiprazole) for extended- release injectable suspension, an intramuscular (IM) depot formulation indicated for the treatment of schizophrenia.

1 Mar 2013

Researchers develop new genetically altered mice that model earliest stages of Alzheimer's

Researchers at the University of Florida and The Johns Hopkins University have developed a line of genetically altered mice that model the earliest stages of Alzheimer's disease. This model may help scientists identify new therapies to provide relief to patients who are beginning to experience symptoms.

1 Mar 2013

UPV/EHU team uses lipid nanoparticles to develop new formulations for drug delivery

At the Faculty of Pharmacy of the Basque Public University (UPV/EHU) the Pharmacokinetics, Nanotechnology and Gene Therapy research team is using nanotechnology to develop new formulations that can be applied to drugs and gene therapy.

1 Mar 2013

Youths addicted to alcohol and drugs can increase their chances of recovery by helping others

A Case Western Reserve University professor has found that young people addicted to alcohol and drugs can increase their chances of recovery by helping others.

28 Feb 2013

Annual deaths related to heroin and morphine continue to drop in the UK

Annual deaths related to heroin and morphine are continuing to drop significantly, falling from 41 per cent of total drug-related deaths in the UK in 2010 to 32 per cent in 2011. Meanwhile, deaths from 'legal highs' - some of which have now been banned - remained steady following a large increase in the previous year.

28 Feb 2013

Drugs News and Research

Study finds how to shut down Bcl6 in diffuse large B-cell lymphoma

Researchers identify mechanisms that connect variety of diseases linked with inflammation

Global inhibition of all Notch signals would not be safe after bone marrow transplantation

Report: Drug companies spent $84M marketing pharmaceuticals in the District of Columbia in 2011

Measles epidemic affecting tens of thousands of children in DRC, MSF warns

Cannabis can be detected in blood of chronic daily smokers for a month after last intake

Study shows triple-negative breast cancer cells missing key enzyme

Bisphosphonate link to nonhealing fractures strengthened

GlaxoSmithKline's HIV/AIDS business joins Medicines Patent Pool

Study shows how theranostic nanoparticles can effectively deliver cancer drugs to tumour cells

Pivotal study of olesoxime in Spinal Muscular Atrophy receives positive interim review

Urea cycle disorder patient successfully treated by Promethera(R) HepaStem in Phase I/II trial in France

Scientists take important step toward designing a uniform protocol for microbiome research

Not all acne bacteria trigger pimples: Study

Researchers develop new method to study complex molecular workings of Anopheles albimanus

Otsuka receives FDA approval for ABILIFY MAINTENA to treat schizophrenia

Researchers develop new genetically altered mice that model earliest stages of Alzheimer's

UPV/EHU team uses lipid nanoparticles to develop new formulations for drug delivery

Youths addicted to alcohol and drugs can increase their chances of recovery by helping others

Annual deaths related to heroin and morphine continue to drop in the UK

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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