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FOXC2 vital to epithelial-mesenchymal transition in breast cancer

Researchers have identified a pivotal protein in a cellular transformation that makes a cancer cell more resistant to treatment and more capable of growing and spreading, making it an inviting new target for drug development.

14 Feb 2013

IAP antagonists may actually increase risk of bone tumors

Cancer drugs should kill tumors, not encourage their spread. But new evidence suggests that an otherwise promising class of drugs may actually increase the risk of tumors spreading to bone, according to researchers at Washington University School of Medicine in St. Louis.

14 Feb 2013

GSK1322322 targets gram-positive bacteria including methicillin-resistant strains of MRSA

An increasing number of bacteria is evolving antibiotic resistance. Much-feared representatives of this steadily growing group include Staphylococci strains. At this point, multi-resistant forms of the bacterium Staphylococcus aureus - the "hospital germ" known commonly by its acronym, MRSA - can only be treated with a select subset of antibiotics as many drugs have simply stopped working. This is precisely why the field of medicine is in desperate need of new treatment options.

14 Feb 2013

President Obama delivers SOTU address, mentioning trade agreements, AIDS-free generation

"President Barack Obama outlined an ambitious agenda in his State of the Union address Tuesday that included raising the minimum wage, increasing spending on infrastructure, attacking climate change and passing gun-control legislation," the Wall Street Journal reports.

14 Feb 2013

FDA grants orphan drug status to Lentigen’s LG631-CD34 for treatment of glioblastoma multiforme

Lentigen Corporation, a biotechnology company specializing in the development and manufacture of lentiviral gene delivery products, announced today that that the U.S. Food and Drug Administration (FDA) has granted orphan drug status to P140K methylguanine methyltransferase (MGMT) transduced human CD34 cells for bone marrow protection in the treatment of glioblastoma multiforme.

14 Feb 2013

New paper advances scientific understanding of glycoproteins’ structure and function

A Simon Fraser University chemist is the lead author on a new paper that advances scientific understanding of the structure and function of glycoproteins, in particular the number and positioning of sugars on them.

14 Feb 2013

Researchers investigate new avenue of treatment to help boost poor pancreatic cancer survival rates

Researchers at Georgia Regents University Cancer Center are investigating a new avenue of treatment to help boost poor pancreatic cancer survival rates.

13 Feb 2013

Antibody therapeutics targeting GPCRs to be developed by alliance between MorphoSys and Heptares

MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) and UK-based Heptares Therapeutics, the leading GPCR drug discovery and development company, have signed an agreement to discover novel antibody therapeutics targeting G protein-coupled receptors (GPCRs), which are membrane proteins involved in a broad range of biological processes and diseases.

13 Feb 2013

Introduced in SOTU by President George W. Bush, PEPFAR has saved millions of lives

"The President's Emergency Plan for AIDS Relief (PEPFAR) exists entirely because of a willing leader, a creative policy team, a smattering of activists and a vast, bleeding need," columnist Michael Gerson writes in a Washington Post opinion piece

13 Feb 2013

New centre to boost development of drugs against TB, malaria and African sleeping sickness

A major new centre to boost the development of drugs to tackle the foremost diseases of the developing world is to be created at the University of Dundee.

13 Feb 2013

Big Pharma looks to Africa for next growth market as economies strengthen, disease burden shifts

"Not only is Africa's economic growth grabbing attention in boardrooms but the shifting nature of its disease burden is luring Big Pharma, as new opportunities open up for treating chronic diseases afflicting the middle classes, rather than just fire-fighting infection," Reuters reports.

13 Feb 2013

New drug delivery system can reduce size of ovarian tumors by as much as 83%

By loading fragile RNA into silicon nanoparticles, researchers from The Methodist Hospital and two other institutions found a new drug delivery system can reduce the size of ovarian tumors by as much as 83 percent -- and stop tumor growth in chemotherapy-resistant ovarian cancer tissue.

13 Feb 2013

Viewpoints: Entitlement spending 'hurts the young;' State uncertainty on Medicaid; Dr. Carson's remedy for health care

Federal spending is the most obvious example. The federal government is a machine that takes money from future earners and spends it on health care for retirees. Entitlement spending hurts the young in two ways. It squeezes government investment programs that boost future growth. Second, the young will have to pay the money back. To cover current obligations, according to the International Monetary Fund, young people will have to pay 35 percent more taxes and receive 35 percent fewer benefits.

13 Feb 2013

University of Utah geneticists engineer mice that develop clear cell sarcoma

Geneticists led by University of Utah Nobel Prize Laureate Mario R. Capecchi, Ph.D., have engineered mice that develop clear cell sarcoma (CCS), a significant step in better understanding how this rare and deadly soft tissue cancer arises. The mouse model also can potentially speed the development of drugs to target genes that must be activated for the cancer to form.

13 Feb 2013

RNAi effective in treating cancer patients

The new study published in Cancer Discovery, the flagship journal of the American Association of Cancer Research (AACR), involving three Spanish and six American research centres, presents significant results in treating cancer patients with nanoparticles containing ribonucleic acid interference (RNAi) molecules.

13 Feb 2013

GSK, Vanderbilt partner to develop and commercialize new therapies for severe obesity

Vanderbilt University announced today that it has signed a collaboration agreement with GlaxoSmithKline (GSK) for the discovery, development and commercialization of novel therapies for severe obesity.

13 Feb 2013

Combining synthetic and natural toxins could disarm cancer, drug-resistant bacteria

Cancer researchers from Rice University suggest that a new man-made drug that's already proven effective at killing cancer and drug-resistant bacteria could best deliver its knockout blow when used in combination with drugs made from naturally occurring toxins.

13 Feb 2013

Boston College biologist receives $2.7M NIH grant to continue HIV and AIDS research

Boston College biologist Ken Williams, whose research focuses on the role of immunological cells in a range of illnesses that strike people living with HIV and AIDS, has been awarded a five-year, $2.7 million grant from the NIH's National Institute of Neurological Disorders and Stroke.

12 Feb 2013

Piroxicam ultrasound combination optimal for knee osteoarthritis

Phonophoresis of the non steroidal anti-inflammatory drug piroxicam with ultrasound is more effective than ultrasound alone for improving pain and other symptoms of mild-to-moderate knee osteoarthritis, show study findings.

12 Feb 2013

Metastatic renal cell carcinoma (mRCC) therapy: an interview with Charles A. Nicolette, Ph.D., CSO of Argos Therapeutics

Metastatic renal cell carcinoma is a devastating disease. There are roughly 20-25,000 new cases per year in the United States and it is increasing for some reason.

12 Feb 2013

Drugs News and Research

FOXC2 vital to epithelial-mesenchymal transition in breast cancer

IAP antagonists may actually increase risk of bone tumors

GSK1322322 targets gram-positive bacteria including methicillin-resistant strains of MRSA

President Obama delivers SOTU address, mentioning trade agreements, AIDS-free generation

FDA grants orphan drug status to Lentigen’s LG631-CD34 for treatment of glioblastoma multiforme

New paper advances scientific understanding of glycoproteins’ structure and function

Researchers investigate new avenue of treatment to help boost poor pancreatic cancer survival rates

Antibody therapeutics targeting GPCRs to be developed by alliance between MorphoSys and Heptares

Introduced in SOTU by President George W. Bush, PEPFAR has saved millions of lives

New centre to boost development of drugs against TB, malaria and African sleeping sickness

Big Pharma looks to Africa for next growth market as economies strengthen, disease burden shifts

New drug delivery system can reduce size of ovarian tumors by as much as 83%

Viewpoints: Entitlement spending 'hurts the young;' State uncertainty on Medicaid; Dr. Carson's remedy for health care

University of Utah geneticists engineer mice that develop clear cell sarcoma

RNAi effective in treating cancer patients

GSK, Vanderbilt partner to develop and commercialize new therapies for severe obesity

Combining synthetic and natural toxins could disarm cancer, drug-resistant bacteria

Boston College biologist receives $2.7M NIH grant to continue HIV and AIDS research

Piroxicam ultrasound combination optimal for knee osteoarthritis

Metastatic renal cell carcinoma (mRCC) therapy: an interview with Charles A. Nicolette, Ph.D., CSO of Argos Therapeutics

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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