Mouse Model News and Research

RSS

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

Patients with sickle cell anemia (SCA) develop heart complications and nearly a quarter die a sudden death. Now, researchers have linked malfunctioning molecular pathways to specific heart anomalies in SCA that result from progressive fibrosis and result in sudden death.

9 Aug 2016

Scientists improve potential weapon to fight against autoimmune disorders

With a trick of engineering, scientists at the Gladstone Institutes improved a potential weapon against inflammation and autoimmune disorders. Their work could one day benefit patients who suffer from inflammatory bowel disease or organ transplant rejection.

9 Aug 2016

Researchers uncover new preventative way to battle against Ascaris roundworm infection

Scientists working out of Trinity College Dublin, Maynooth University, and Queen Mary University of London have unearthed a potential new preventative option to combat Ascaris roundworm infection.

8 Aug 2016

New study shows hedgehog signalling offers protection against colon cancer

Many types of cancer are caused by gene mutations in the signalling pathways that control cell growth, such as the hedgehog signalling pathway.

8 Aug 2016

Research shows alcohol abuse drug inhibits ocular conjunctival scarring in mouse model

New research from University College London, Moorfields Eye Hospital and Duke University School of Medicine has identified a gene that drives scarring, together with a rapidly translatable therapy, for the UK's most common cause of blinding conjunctivitis.

4 Aug 2016

Studies highlight key role for vitamin A metabolite retinoic acid in ocular fibrosis

Mucous membrane pemphigoid is an autoimmune disease that causes inflammation and scarring in mucosal tissues. Affected individuals frequently exhibit scarring in the eye, which can lead to blindness in as many as 20% of patients.

4 Aug 2016

Combinations of FDA-approved drugs may prevent vision loss linked to retinal degeneration

Combinations of Food and Drug Administration-approved drugs protect against the loss of cells required for vision in a mouse model of blinding retinal diseases.

4 Aug 2016

Scientists uncover genetic cause of rare pediatric progressive neuropathy

Researchers from the National Institutes of Health and their colleagues identified the genetic cause and a possible therapeutic target for a rare form of pediatric progressive neuropathy.

3 Aug 2016

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Reprogramming of the molecular pathways underlying normal metabolism is essential for T cell infection-fighting function and for the immune system to form a "memory" of the microbes it has already encountered. But exactly how metabolism in exhausted T cells is maintained in chronic infections and cancer is a missing element in this line of research.

3 Aug 2016

Study clarifies role of KLF12 in CRC tumor growth

Results of preclinical studies by MUSC investigators reported in the July 2016 issue of PLOS One, demonstrate for the first time that the transcription factor KLF12 promotes CRC cell growth, in part, by activating EGR1. Furthermore, data demonstrate that KLF12 and EGR1 levels synergistically correlate with poor CRC prognoses.

29 Jul 2016

Triple-combination therapy patch shrinks tumors, prevents recurrence in colon cancer mice model

Investigators at Brigham and Women's Hospital have developed a hydrogel patch that can adhere to tumors in a preclinical model of colon cancer, delivering a local, combination treatment as the elastic gel breaks down over time.

29 Jul 2016

Novel method sheds light on how disruption in LRRK2 gene causes inherited Parkinson's disease

Scientists have developed a new method of measuring the activity of disease-causing mutations in the LRRK2 gene, a major cause of inherited Parkinson's disease.

29 Jul 2016

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Researchers at UC Davis and Ionis Pharmaceuticals have developed a hybrid treatment that harnesses a monoclonal antibody to deliver antisense DNA to acute lymphoblastic leukemia (ALL) cells and that may lead to less toxic treatments for the disease.

29 Jul 2016

ZMYND8 protein can suppress metastasis-linked genes in prostate cancer

Although it reads like European license plate number, a protein known as ZMYND8 has demonstrated its ability to block metastasis-linked genes in prostate cancer, according to a study at The University of Texas MD Anderson Cancer Center.

28 Jul 2016

New research elucidates details about architecture of synaptic transmission

For more than a century, neuroscientists have known that nerve cells talk to one another across the small gaps between them, a process known as synaptic transmission.

28 Jul 2016

Mice study shows stem cell infusion could help treat glaucoma

An infusion of stem cells could help restore proper drainage for fluid-clogged eyes at risk for glaucoma. That's the upshot of a study led by a Veterans Affairs and University of Iowa team.

26 Jul 2016

Researchers find conceivable alternative way to treat Pompe disease

Researchers at Duke Health have identified a potential new avenue for treating Pompe disease, a rare condition caused by the build-up of glycogen, a storage form of sugar, in cardiac and skeletal muscle, the liver and other tissues, due to deficiency of a particular enzyme.

25 Jul 2016

Mouse Model News and Research

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

Scientists improve potential weapon to fight against autoimmune disorders

Researchers uncover new preventative way to battle against Ascaris roundworm infection

New study shows hedgehog signalling offers protection against colon cancer

Research shows alcohol abuse drug inhibits ocular conjunctival scarring in mouse model

Studies highlight key role for vitamin A metabolite retinoic acid in ocular fibrosis

Combinations of FDA-approved drugs may prevent vision loss linked to retinal degeneration

Scientists uncover genetic cause of rare pediatric progressive neuropathy

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Study clarifies role of KLF12 in CRC tumor growth

Triple-combination therapy patch shrinks tumors, prevents recurrence in colon cancer mice model

Novel method sheds light on how disruption in LRRK2 gene causes inherited Parkinson's disease

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

ZMYND8 protein can suppress metastasis-linked genes in prostate cancer

New research elucidates details about architecture of synaptic transmission

Mice study shows stem cell infusion could help treat glaucoma

Researchers find conceivable alternative way to treat Pompe disease

Salmonella protein can reduce drug resistant molecule found in cancer cells

Researchers identify important therapeutic target for small cell lung cancer

Study highlights role of BCL11A gene in intellectual disability syndrome

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

Latest News