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ASTN2 gene knockout in mice reveals key autism-related behaviors

More than 70 genes have been linked to autism spectrum disorder (ASD), a developmental condition in which differences in the brain lead to a host of altered behaviors, including issues with language, social communication, hyperactivity, and repetitive movements.

16 Aug 2024

New insights into COVID-19 spike protein offer hope for universal vaccines

A team led by Jose Onuchic at Rice University and Paul Whitford at Northeastern University, both researchers at the National Science Foundation Physics Frontiers Center at the Center for Theoretical Biological Physics (CTBP) at Rice, has made a discovery in the fight against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus responsible for COVID-19.

16 Aug 2024

Study highlights LLPS's influence on signaling pathways and disease progression

This paper, led by Professor Wu (Wenzhou Institute University, Wenzhou Medical University) and Professor Huang (Northeastern University), explores LLPS, a phenomenon closely associated with various diseases, including cancer and neurodegenerative disorders.

16 Aug 2024

Uncovering the mechanisms behind bacterial cell shape and potential antibiotic targets

In what they labeled a "surprising" finding, Johns Hopkins Medicine researchers studying bacteria from freshwater lakes and soil say they have determined a protein's essential role in maintaining the germ's shape.

16 Aug 2024

Scientists find way to restore brain's self-cleaning function

Alzheimer's, Parkinson's, and other neurological disorders can be seen as "dirty brain" diseases, where the brain struggles to clear out harmful waste. Aging is a key risk factor because, as we grow older, our brain's ability to remove toxic buildup slows down. However, new research in mice demonstrates that it's possible to reverse age-related effects and restore the brain's waste-clearing process.

16 Aug 2024

Scientists discover key age-related biological shifts at 40 and 60

Researchers uncover the nonlinear dynamics of aging, revealing significant biological shifts at ages 40 and 60, offering new insights into age-related diseases.

16 Aug 2024

Saliva test offers hope for head and neck cancer patients

But what if a mouthwash-based test to detect biomarkers can help physicians predict disease recurrence in head and neck cancer patients?

16 Aug 2024

Infections drive brain volume loss and dementia risk by altering key immune proteins, study reveals

Severe infections are linked to increased brain atrophy, particularly in the temporal lobe, which may elevate dementia risk through immune-related proteins.

15 Aug 2024

Researchers reveal why a diet rich in magnesium is so important for your health

Researchers examined whether magnesium deficiency in the healthy middle-aged Australian population was independently or in combination with increased homocysteine levels associated with in vivo DNA damage.

15 Aug 2024

Anti-inflammatory diets could lower dementia risk among older individuals with cardiometabolic disorders

Researchers investigated whether anti-inflammatory diets support cognitive functions among cardiometabolic disease (CMD) patients.

15 Aug 2024

New research gives unprecedented view of colorectal cancer genetic makeup

Researchers provided a comprehensive genomic characterization of colorectal carcinoma, a type of cancer that starts in the colon or rectum, through whole-genome sequencing of 2,023 samples, identifying novel driver genes, molecular subgroups, and potential clinical implications.

15 Aug 2024

Coffee may benefit patients with low muscle mass, says U.S. study

Higher coffee and caffeine intake are linked to increased skeletal muscle mass, but this association disappears in individuals with a BMI of 30 kg/m² or higher.

14 Aug 2024

Study reveals a paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia

Researchers at Children's Hospital of Philadelphia (CHOP), St. Jude Children's Research Hospital (St. Jude) and the Children's Oncology Group (COG) today announced a significant paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia (T-ALL), an aggressive and high-risk form of cancer, to one frequently driven by genetic changes in non-coding portions of our DNA.

14 Aug 2024

Very-low-calorie keto diet slashes fat and oxidative stress, boosting metabolic health in obesity

Study reveals that an 11-week, very-low-calorie ketogenic diet significantly reduces body fat and improves glucose metabolism in obese individuals, while also lowering oxidative stress markers, indicating better overall metabolic health.

14 Aug 2024

New tool shows promise for assessing neurobehavioral difficulties in children with Duchenne muscular dystrophy

A pilot study using a new screening tool shows promise for assessing neurobehavioral difficulties in children with Duchenne muscular dystrophy (DMD) and improving quality of life for patients and their families.

14 Aug 2024

Ketogenic diet can boost efficacy of pancreatic cancer therapy

A study of fasting and the ketogenic diet reveals a new vulnerability of pancreatic tumors to an existing cancer drug.

14 Aug 2024

Study finds no clinically useful biomarkers for long COVID in routine lab tests

Whether tests in current use were adequate to identify post-acute sequelae of SARS-CoV-2 (PASC).

14 Aug 2024

New targets for improved cancer immunotherapy

In the past two decades, immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, showing promising results against various solid tumors. This study reviews recent developments in ICIs, focusing on new targets like T cell immunoreceptors with Ig and ITIM domains (TIGIT), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), and lymphocyte activation gene-3 (LAG-3). These targets aim to overcome resistance mechanisms limiting the effectiveness of current therapies, such as anti-PD-1 and anti-CTLA-4. By identifying and developing these new ICIs, researchers hope to improve treatment outcomes and provide new therapeutic options for cancer patients.

14 Aug 2024

Early detection key to beating ovarian cancer

'Symptom triggered testing', prompted by symptoms such as pain, abdominal bloating/swelling, and feeling full soon after starting to eat, can pick up early stage aggressive ovarian cancer in 1 in 4 of those affected, finds a data analysis, published online in the International Journal of Gynecological Cancer.

14 Aug 2024

Novel vaccination strategy shows promise in boosting immunity and controlling influenza spread in pigs

Study demonstrates that a novel prime/boost vaccination protocol using live-attenuated influenza vaccines effectively induces strong immune responses in pigs, offering a promising approach for future influenza vaccination strategies.

13 Aug 2024