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Pill color switch disrupts medication adherence

Simply changing the appearance of a prescription medication can significantly alter patients’ compliance with treatment, study findings show.

14 Jan 2013

Biguanide mechanism discovered

Researchers have discovered a novel mechanism by which biguanides exert their glucose-lowering effect, potentially leading to new therapeutic approaches to the treatment of diabetes and insulin resistance.

14 Jan 2013

Off-label drug ineffective in frontotemporal dementia

A randomized, controlled trial has dashed hopes that memantine therapy could benefit patients with frontotemporal dementia.

14 Jan 2013

Greater selectivity in GI bleeding prophylaxis needed

Researchers have developed a risk-scoring system to identify noncritically ill hospital patients most likely to benefit from prophylactic acid-suppressive medication.

14 Jan 2013

Communication key in helping patients adhere to medicine

Patients are less likely to take their medications properly if they feel their family doctor or other primary care clinician is failing to communicate with them adequately, suggests a US study published in the Archives of Internal Medicine.

14 Jan 2013

Multidisciplinary team work on proactive approach to flu vaccine design

An internationally recognized expert in viruses, Robert W. Finberg, MD, the Richard M. Haidack Professor of Medicine and chair and professor of medicine at the University of Massachusetts Medical School, is lead investigator on a $12 million project to develop new ways of predicting how the influenza virus changes and evolves in response to anti-viral drugs and the human immune system. This approach has promise for becoming a pivotal tool in creating a more effective vaccine against the virus.

11 Jan 2013

Fiscal cliff boosts clinical data registries, but cuts some health care payments

CQ HealthBeat reports on a provision of the fiscal cliff law intended to encourage physicians to submit data to registries that could be a tool to promote better quality care. The Medicare NewsGroup analyzes another provision that changes how payments are calculated for end stage renal disease drugs.

11 Jan 2013

UCSF teams to study new ways to reduce childhood mortality and disease in developing nations

Two UCSF teams have received a total of $16 million from the Bill & Melinda Gates Foundation to study new ways to significantly reduce childhood mortality and disease in developing nations.

11 Jan 2013

Longer looks: A key Hagel mission is to cut military health costs; Medical lessons from a mother's death; How they price - and how we pay for -a $300,000 medicine

As David Brooks and Paul Wolfowitz and many others have shown, it's easy to frame our messy fiscal conundrum in these simple terms of guns vs. butter, or rather, guns vs grandma's buttery-yellow, super-pricey heart medication.

11 Jan 2013

FDA requires sleep drugs that contain zolpidem to lower recommended doses

The U.S. Food and Drug Administration today announced it is requiring the manufacturers of Ambien, Ambien CR, Edluar and Zolpimist, widely used sleep drugs that contain the active ingredient zolpidem, to lower current recommended doses. Ambien and Ambien CR are also available as generics.

11 Jan 2013

Viewpoints: Rove says GOP unlikely to make much 'structural change' to entitlements; Roe anniversary and fading public understanding; Fast food workers' health insurance

As a matter of policy, rather than politics, it is no more sensible to draw the line at $620 billion in additional revenue over the next decade than to insist, as have some Democrats, that Medicare and Social Security remain untouched. The country's structural deficit poses too large a threat to future prosperity, and there is no politically or fiscally realistic scenario under which entitlement cuts alone can solve the problem.

11 Jan 2013

New guidelines to help fast track radiation oncology drug development

Researchers from the translational research program of the National Cancer Institute and the Radiation Therapy Oncology Therapy Group have developed new guidelines to help fast track the clinical development of targeted cancer drugs in combination with radiation therapy.

11 Jan 2013

Scientists develop playbook to end devastating impact of fibrotic diseases

A team of scientists has developed a playbook for ending the devastating impact of fibrotic diseases of the liver, lung, kidney, and other organs, which are responsible for as many as 45 percent of all deaths in the industrialized world.

11 Jan 2013

Patients at high-risk for recurrent C. difficile with unnecessary antibiotic use

The impact of antibiotic misuse has far-reaching consequences in healthcare, including reduced efficacy of the drugs, increased prevalence of drug-resistant organisms, and increased risk of deadly infections. A new study featured in the February issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America, found that many patients with Clostridium difficile infection (C. difficile) are prescribed unnecessary antibiotics, increasing their risk of recurrence of the deadly infection.

10 Jan 2013

Study compares three treatment approaches in membranous nephropathy

The results of a pioneering UK-wide clinical trial that compared treatments for patients with a common type of kidney disease has found one to be significantly more effective. The results of the study, published online in The Lancet, will be recommended to clinicians worldwide as the most effective approach to treating the condition.

10 Jan 2013

MSF, DNDi analysis shows increased investment in NTDs but low number of new therapy approvals

"Over the past decade, neglected diseases have attracted increased attention and larger investments in research," but "a new analysis by Medecins Sans Frontieres (MSF) and the Drugs for Neglected Diseases Initiative (DNDi) finds that the rate of approvals for new compounds over the past decade is roughly the same as it was during the previous two-and-a-half decades, when the diseases received little attention," Nature Medicine reports.

10 Jan 2013