Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Expansion stress promotes aggressive tumor cell growth in breast cancer

Expansion stress can have an alarming impact on breast cancer cells by creating conditions that could lead to dangerous acceleration of the disease, an interdisciplinary team of University of Alabama at Birmingham researchers has found.

9 Jul 2020

New research can help overcome challenges in diabetes research

Scientists focused on finding better treatments or cures for types 1 or 2 diabetes are painfully aware of current limitations, including having to use animal tissue in studies that often don't translate to human trials.

9 Jul 2020

Research sheds light on mysterious COVID-19 related hyperinflammatory shock in children

The ongoing COVID-19 pandemic has cost hundreds of thousands of human lives, besides more than 11 million cases. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the disease was initially thought to be more severe in the elderly and those with pre-existing medical conditions. However, it started to manifest in children after the peak of the first wave.

7 Jul 2020

Faulty immune response to SARS-CoV-2 one of the main causes of death

A new study published on the preprint server medRxiv in July 2020 describes the organ and tissue-specific spread of the virus causing the current COVID-19 pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

7 Jul 2020

Researchers identify immune cell that predicts transplant patient's risk of organ rejection

Researchers at The Ohio State University College of Medicine are the first to identify an immune cell that may predict a transplant patient's risk of developing antibodies that can cause organ rejection.

6 Jul 2020

Striking differences found between NHS trusts in COVID-19 ICU deaths

A University of Cambridge team led by Professor Mihaela van der Schaar and intensive care consultant Dr Ari Ercole of the Cambridge Centre for AI in Medicine is calling for urgent research into the striking differences in COVID-19 deaths they have discovered between the intensive care units of NHS trusts across England.

23 Jun 2020

FDA approved drugs active against COVID-19

With the rapid spread of the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) throughout the world, causing the current COVID-19 pandemic, there is an urgent need for new antivirals and vaccines to combat its spread. The current study published on the preprint server bioRxiv in June 2020 shows some of the results of the extensive repurposing of already FDA-approved drugs.

23 Jun 2020

Crystal structure of SARS-CoV-2 protease-inhibitor in complex with a Chinese herb Shikonin

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has been spreading rampantly over the whole world, infecting millions of people (over 8.45 million at last count), with over 452,000 deaths, as of June 19, 2020. It causes a broad spectrum of disease manifestations, from asymptomatic disease to severe or even fatal respiratory symptoms.

18 Jun 2020

Cyclosporin study may pave way for treating diseases related to mitochondrial dysfunction

Cyclic peptide molecules of the fungal origin called cyclosporins were discovered in 1970's, and cyclosporin A soon became an important drug due to its immunosuppressive activity.

18 Jun 2020

Repurposing immunosuppressants to manage COVID-19

It might seem paradoxical to suggest immunosuppression could play a role in managing COVID-19. The seemingly logical therapeutic option for this disease would be an antiviral.

18 Jun 2020

C-Path's Transplant Therapeutics Consortium receives positive FDA response for its Letter of Intent

Critical Path Institute announced today that its Transplant Therapeutics Consortium has received a positive response to its Letter of Intent from the U.S. Food and Drug Administration detailing the decision to accept the Composite Biomarker Panel (iBox Scoring System) into the Center for Drug Evaluation and Research (CDER) Biomarker Qualification Program.

17 Jun 2020

Maternal SARS-CoV-2 infection not harmful in first trimester pregnancies

A new Danish study published on the preprint server medRxiv in June 2020 shows that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in early pregnancy does not carry an increased risk of fetal harm.

10 Jun 2020

Study shows safety of new cell therapy approaches for kidney transplant recipients

A large international study coordinated by University Hospital Regensburg and Charité - Universitätsmedizin Berlin has demonstrated the safety of new cell therapy approaches for use in kidney transplant recipients.

10 Jun 2020

Heart transplant recipients affected by COVID-19 face racial, gender disparities

Physician-scientists specializing in heart failure wanted to know: if their heart transplant patients contract COVID-19, would they have a different experience than the general public or others who are also immunosuppressed?

9 Jun 2020

Tocilizumab in COVID-19 patients on mechanical ventilation

Now, a new study by researchers from the University of Michigan and published on the online preprint server medRxiv* in June 2020 shows that the cytokine inhibitor tocilizumab could have a favorable effect on survival in the most severely infected patients who require mechanical ventilation. This needs to be confirmed by clinical trials.

7 Jun 2020

Comparing genomes to understand how mutations affect the COVID-19 pandemic

Now, a new study by researchers at the Massachusetts Institute of Technology and the Center for Computational Biology, Flatiron Institute and published online on the bioRxiv preprint server describes how the use of comparative genomics helps to identify protein-coding and non-coding functional genes.

4 Jun 2020

Age and diabetes the biggest risk factors for death in pregnant COVID-19 patients

A recent research letter published on the preprint server medRxiv in June 2020 evaluates the risk factors that may lead to higher mortality in pregnant women with COVID-19 in middle-income countries.

4 Jun 2020

Study investigates outcome of COVID-19 infection in blood cancer patients

One of the first studies to investigate the outcome of COVID-19 infection in patients with blood cancer has been conducted by clinical researchers from Queen Mary University of London and Barts Health NHS Trust.

2 Jun 2020

Specific immune suppression leads to severe COVID-19 disease

A new study published online on the preprint server medRxiv in May 2020 reports that specific changes in the way the human immune system responds to COVID-19 determine whether the individual develops moderate or severe illness.

2 Jun 2020

Zero benefit of Hydroxychloroquine or Chloroquine in COVID-19, says extensive study

The purported "game-changer" anti-malarial drug Hydroxychloroquine, which was claimed to be effective in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and also helping better outcomes in COVID-19 patients, seems to have failed in clinical trials.

25 May 2020

Immunosuppression News and Research

Further Reading

Expansion stress promotes aggressive tumor cell growth in breast cancer

New research can help overcome challenges in diabetes research

Research sheds light on mysterious COVID-19 related hyperinflammatory shock in children

Faulty immune response to SARS-CoV-2 one of the main causes of death

Researchers identify immune cell that predicts transplant patient's risk of organ rejection

Striking differences found between NHS trusts in COVID-19 ICU deaths

FDA approved drugs active against COVID-19

Crystal structure of SARS-CoV-2 protease-inhibitor in complex with a Chinese herb Shikonin

Cyclosporin study may pave way for treating diseases related to mitochondrial dysfunction

Repurposing immunosuppressants to manage COVID-19

C-Path's Transplant Therapeutics Consortium receives positive FDA response for its Letter of Intent

Maternal SARS-CoV-2 infection not harmful in first trimester pregnancies

Study shows safety of new cell therapy approaches for kidney transplant recipients

Heart transplant recipients affected by COVID-19 face racial, gender disparities

Tocilizumab in COVID-19 patients on mechanical ventilation

Comparing genomes to understand how mutations affect the COVID-19 pandemic

Age and diabetes the biggest risk factors for death in pregnant COVID-19 patients

Study investigates outcome of COVID-19 infection in blood cancer patients

Specific immune suppression leads to severe COVID-19 disease

Zero benefit of Hydroxychloroquine or Chloroquine in COVID-19, says extensive study

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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