Leptin News and Research

RSS

Leptin is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. It is one of the most important adipose derived hormones. The ''Ob(Lep)'' gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans.

Leptin gene therapy aids weight loss without significant side effect of bone loss

Delivering the hormone leptin directly to the brain through gene therapy aids weight loss without the significant side effect of bone loss, according to new collaborative research from Oregon State University and University of Florida.

22 Oct 2015

High levels of satiety hormone leptin contribute to cardiovascular disease in obese individuals

While high levels of the satiety hormone leptin don't help obese individuals lose weight, they do appear to directly contribute to their cardiovascular disease, researchers report.

8 Oct 2015

High dietary iron intake suppresses hormone that regulates appetite

Here's one more reason to cut down on the amount of red meat you eat. Using an animal model, researchers at Wake Forest Baptist Medical Center have found that dietary iron intake, equivalent to heavy red meat consumption, suppresses leptin, a hormone that regulates appetite.

25 Aug 2015

Improved method for building proteins into antibodies

Some proteins exist so fleetingly in the bloodstream that they can't be given effectively as therapies. However, building them into larger proteins, such as antibodies, can make them persist long enough to be useful. Now a team led by scientists at The Scripps Research Institute (TSRI) has devised an improved method for accomplishing this protein-engineering feat.

14 Aug 2015

TSRI-led team devises selection-based, protein-engineering method to work on obesity therapy

Some proteins exist so fleetingly in the bloodstream that they can’t be given effectively as therapies. However, building them into larger proteins, such as antibodies, can make them persist long enough to be useful. Now a team led by scientists at The Scripps Research Institute has devised an improved method for accomplishing this protein-engineering feat.

14 Aug 2015

New study shows high-fat diet can cause impairments in functioning of mesolimbic dopamine system

High-fat feeding can cause impairments in the functioning of the mesolimbic dopamine system, says Stephanie Fulton of the University of Montreal and the CHUM Research Centre. This system is a critical brain pathway controlling motivation. Fulton's findings, published today in Neuropsychopharmacology, may have great health implications.

15 Jul 2015

UC Riverside researchers explore effects of early-life exercise

More than one in three adults in the United States is considered to be obese. What impact can exercise done early in life have on the propensity for exercising during the adult years? A team of researchers at the University of California, Riverside did experiments on mice in the lab to find out. Specifically, they evaluated the effects of early exercise on adult physical activity, body mass, food consumption and circulating leptin levels.

25 Jun 2015

Rapamycin drug reduces obesity, preserves lean body mass in older rats

Aging can cause many changes to the body, including obesity and a loss of lean mass. Now, a group of University of Florida Health researchers has discovered that an existing drug reduces body fat and appetite in older rats, which has intriguing implications for aging humans.

17 Jun 2015

Leptin resistance not a possible cause of obesity, scientists find

For years, scientists have pointed to leptin resistance as a possible cause of obesity. Research led by investigators at the University of Cincinnati (UC) Metabolic Diseases Institute, however, found that leptin action isn't the culprit.

19 May 2015

Researchers discover genetic factors key to POMC cells

The little voice inside your head that tells you to eat, or stop eating, isn't a little voice - it's actually a cluster of about 10,000 specialized brain cells. And now, an international team of scientists has found tiny triggers inside those cells that give rise to this "voice", and keep it speaking throughout life.

6 Apr 2015

Physicians develop new quality measures for treatment of childhood obstructive sleep apnea

A work group of physicians from leading academic medical centers across the country, including NYU Langone Medical Center, has developed new quality measures for the detection and treatment of childhood obstructive sleep apnea (OSA), a potentially morbid, life-altering condition that affects hundreds of thousands of children and adolescents nationwide.

16 Mar 2015

Obese females with eating/behavioral characteristic have impaired metabolism

In obese females, a close relationship may exist between their disinhibition (detrimental eating and behavioral characteristics) that limits successful weight loss, and impaired metabolism, new research shows.

9 Mar 2015

Researchers successfully convert adult human skin cells into neurons that control appetite

Researchers have for the first time successfully converted adult human skin cells into neurons of the type that regulate appetite, providing a patient-specific model for studying the neurophysiology of weight control and testing new therapies for obesity.

28 Feb 2015

Scientists develop potential new therapy based on cow's immune molecules for hormone deficiencies

To help people with hormone deficiencies, scientists at The Scripps Research Institute have developed a potential new therapy based on an unlikely model: immune molecules from cows.

9 Feb 2015

Using antioxidant to reverse brain inflammation improves obesity, diabetes symptoms

Using an antioxidant to reverse inflammation in the brain caused by a high-fat diet greatly improves symptoms related to obesity and type II diabetes, a new study from New Zealand's University of Otago suggests.

30 Jan 2015

Researchers identify molecular pathways that could lead to new therapeutic targets for cerebral malaria

A drug already approved for treating other diseases may be useful as a treatment for cerebral malaria, according to researchers at Harvard T. H. Chan School of Public Health. They discovered a novel link between food intake during the early stages of infection and the outcome of the disease, identifying two molecular pathways that could serve as new targets for treatment.

30 Jan 2015

Leptin News and Research

Further Reading

Leptin gene therapy aids weight loss without significant side effect of bone loss

High levels of satiety hormone leptin contribute to cardiovascular disease in obese individuals

High dietary iron intake suppresses hormone that regulates appetite

Improved method for building proteins into antibodies

TSRI-led team devises selection-based, protein-engineering method to work on obesity therapy

New study shows high-fat diet can cause impairments in functioning of mesolimbic dopamine system

UC Riverside researchers explore effects of early-life exercise

Rapamycin drug reduces obesity, preserves lean body mass in older rats

Leptin resistance not a possible cause of obesity, scientists find

Researchers discover genetic factors key to POMC cells

Physicians develop new quality measures for treatment of childhood obstructive sleep apnea

Obese females with eating/behavioral characteristic have impaired metabolism

Researchers successfully convert adult human skin cells into neurons that control appetite

Scientists develop potential new therapy based on cow's immune molecules for hormone deficiencies

Using antioxidant to reverse brain inflammation improves obesity, diabetes symptoms

Researchers identify molecular pathways that could lead to new therapeutic targets for cerebral malaria

Research findings may accelerate work to safely control diabetes

CWRU researchers find mechanism that enables LRAT enzyme to store vitamin A

Enzymatic activity essential for vision may provide target for drug transport

Hormone leptin increases blood pressure that occurs with weight gain

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News