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HMGN1 gene linked to heart problems in people with Down syndrome

Nearly half of all babies born with Down syndrome face congenital heart defects, often involving serious malformations that require surgery in the first months of life.

22 Oct 2025

New discovery could someday help prevent breast cancer recurrence

Know someone who's been diagnosed with breast cancer? There's a good chance that person has received hormone therapy.

21 Oct 2025

Researchers discover how a brain circuit allows eating despite anxiety

How do mammals manage to eat in situations that cause anxiety, step into exposed spaces, or slow down when anxiety drives them to keep moving? A new study pinpoints a leptin-sensitive circuit in the lateral hypothalamus that helps to overcome anxiety to perform essential behaviors such as exploring, feeding, and limiting maladaptive hyperactivity.

21 Oct 2025

Study reveals how a microglial mutation increases risk for Alzheimer's disease

Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer's Disease by Impairing Microglial Function."

17 Oct 2025

Runx1 overexpression triggers early intervertebral disc degeneration

A new research paper was published in Volume 17, Issue 9 of Aging-US on September 8, 2025, titled, "Runx1 overexpression induces early onset of intervertebral disc degeneration."

17 Oct 2025

Blocking key protein restores healthy lung function and reduces fibrosis in mice

Pulmonary fibrosis is a deadly disease in which the lungs become thickened and scarred, gradually losing their ability to deliver oxygen to the body.

16 Oct 2025

Fatty acids found to be a primary driver of triple-negative tumor growth

A team from Huntsman Cancer Institute at the University of Utah (the U) has found that triple-negative breast cancer is fueled by lipids and that these fatty acids are a key feature of obesity that promote tumor growth.

16 Oct 2025

Low-dose steroids show promise for treating severe kidney inflammation

Will it be possible to treat severe kidney inflammation with fewer drugs in the future? A new study by the University Hospital Bonn (UKB), the University of Bonn, and the University of Hamburg gives cause for hope.

15 Oct 2025

Discovery explains why women face higher risk of Alzheimer’s and multiple sclerosis

New research by UCLA Health has identified a sex-chromosome linked gene that drives inflammation in the female brain, offering insight into why women are disproportionately affected by conditions such as Alzheimer's disease and multiple sclerosis as well as offering a potential target for intervention.

15 Oct 2025

Estradiol and estriol may protect nerve function in multiple sclerosis

About 100,000 of the estimated million people in the United States with multiple sclerosis (MS) have a progressive form of the disease, with symptoms that worsen continuously or after periods of remission.

14 Oct 2025

New approach protects the brain from radiation-induced cognitive decline

While tremendous relief comes from successfully battling cancer, survivors can also experience cognitive impairments caused by the disease and its treatment.

14 Oct 2025

Scientists revive diabetic beta cells, revealing a new path to restore insulin function

Researchers demonstrated that pancreatic β cells from type 2 diabetes donors can partially regain glucose responsiveness when cultured outside the diabetic environment. This recovery, driven by specific gene expression changes, identifies JAK inhibitors as potential therapeutic candidates to restore β-cell function.

14 Oct 2025

Natural nasal microbes offer broad-spectrum antiviral protection

Respiratory viral diseases pose severe threats to animal health and global food security, especially in intensive pig farming systems.

10 Oct 2025

Study reveals how DKK3 triggers smooth muscle cell transformation in aortic aneurysm

Abdominal aortic aneurysm (AAA) is a life-threatening vascular disorder that primarily affects elderly males.

10 Oct 2025

Study reveals acidic conditions as key to pancreatic cancer survival

Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful metabolic products constantly stress cancer cells.

9 Oct 2025

New gene therapy reverses symptoms of SYNGAP1-related disorders in mice

In an exciting scientific first, researchers at the Allen Institute successfully designed a new gene therapy that reversed symptoms related to SYNGAP1-related disorders (SRD) in mice.

9 Oct 2025

Natural sweetener improves hair loss treatment

Androgenetic alopecia is a common form of hair loss in both men and women-also called male pattern baldness and female pattern hair loss.

9 Oct 2025

Nasal spray of gold nanoparticles delivers lithium directly to the brain

In the form of a 'nasal spray', tiny gold particles act as carriers, delivering a treatment directly to the brain: developed by scientists at the Università Cattolica Rome campus/Fondazione Policlinico Universitario A. Gemelli IRCCS, a new nanotechnological device for the treatment and prevention of neuropsychiatric and neurodegenerative diseases.

8 Oct 2025

Deregulated miR-145 and miR-27b impact adipogenesis in Hutchinson-Gilford progeria syndrome

A new research paper was published in Volume 17, Issue 9 of Aging-US on August 27, 2025, titled, "Deregulated miR-145 and miR-27b in Hutchinson-Gilford progeria syndrome: implications for adipogenesis."

7 Oct 2025

Investigating cannabidiol's role in combating Alzheimer's-related neuroinflammation

Neuroinflammation damages neurons and can contribute to diseases like Alzheimer's. Cannabidiol (CBD) has anti-inflammatory properties, which suggests that it could combat neuroinflammation in Alzheimer's.

6 Oct 2025