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First Edition: September 4, 2012

Today's early morning highlights from the major news organizations, including previews of the Democratic convention and a New York Times analysis of how the Obama and Romney campaigns vary on Medicaid policy.

4 Sep 2012

Converting blood cells to a stem cell state: an interview with Elias Zambidis, M.D., Ph.D.

The primitive stem cell state we created is called an “induced pluripotent stem cell” (iPSC). iPSC are a new, unique, and artificially-created type of stem cell that were first described in 2006 by a Japanese scientist named Shinya Yamanaka.

4 Sep 2012

Obesity no barrier to knee replacement surgery

Health policy should not withhold total knee arthroplasty from patients on the basis of obesity, say UK researchers.

3 Sep 2012

Some smaller clots may not require potentially risky treatment

Men and women who undergo joint replacement procedures, as well as those who have significant fractures, tend to be at an increased risk of developing pulmonary emboli (PE), blood clots that travel to the lungs where they may cause serious complications and even death.

1 Sep 2012

Dabigatran exposure may RE-LY on genetics

Researchers have found that variants in the ABCB1 and CES1 genes are associated with increased dabigatran plasma levels in patients taking the oral anticoagulant.

30 Aug 2012

Emergency readmission after endoscopy linked to mortality risk

The risk for mortality is significantly increased among patients who are readmitted urgently following endoscopy, compared with other endoscopy patients, a UK study shows.

30 Aug 2012

Combination of POZEN’s PA32540 and clopidogrel results in greater antiplatelet effects

POZEN Inc., a pharmaceutical company committed to transforming medicine that transforms lives, announced the presentation of Phase 1 data, at the European Society of Cardiologists 2012 Congress, from a study of PA32540, a novel coordinated-delivery tablet of enteric-coated (EC) aspirin (325 mg) and immediate-release (IR) omeprazole (40 mg).

30 Aug 2012

PROTECT: Still no clear winner in the battle of the stent generations

Three-year rates of stent thrombosis with zotarolimus- and sirolimus-eluting stents are low and comparable, show results of the PROTECT trial.

29 Aug 2012

AstraZeneca’s ticagrelor receives Class I recommendation from ESC

AstraZeneca today announced that ticagrelor, an oral antiplatelet medicine, received a Class I recommendation from the European Society of Cardiology (ESC) in the revised "Guidelines on the Management of Acute Myocardial Infarction in Patients Presenting with Persistent ST-Segment Elevation (STEMI)" guidelines.

29 Aug 2012

Omitting aspirin leads to less bleedings but does not increase risk of stent thrombosis, MI

Lifelong anticoagulation is necessary for the prevention of stroke in patients with rhythm disturbances and with mechanical valves. Patients who have a coronary stent implanted also need the antiplatelet drugs aspirin and clopidogrel to prevent the rare but lethal complication of stent thrombosis.

29 Aug 2012

March of Dimes emergency preparedness tips for pregnant women and new parents

Pregnant women evacuating their homes in advance of Hurricane Isaac should be sure to bring their medication, including their prenatal vitamins, as well as their medical records and their health care providers' emergency contact number.

29 Aug 2012

Study raises cautionary note about preferential use of endovascular technique for ruptured AAA

A new study raises a cautionary note about the increasing use of a minimally invasive procedure to repair ruptured abdominal aortic aneurysms, according to vascular surgeon Dr. Jae Sung Cho of Loyola University Medical Center.

28 Aug 2012

ICU misdiagnosis alarmingly common in the acute care setting

Each year as many as 40,500 critically ill U.S. hospital patients die with an unknown medical condition that may have caused or contributed to their death, Johns Hopkins patient safety experts report in a recent study.

28 Aug 2012

Personalized antiplatelet treatment leads to better outcomes in patients undergoing PCI

Personalized antiplatelet treatment leads to better outcomes than standard antiplatelet treatment in patients undergoing coronary stent implantation, according to results from the MADONNA study presented at ESC Congress 2012.

28 Aug 2012

Study: Lower use of drug eluting stents in women treated with PCI than men

Drug eluting stents (DES) are used less often in women treated with percutaneous coronary intervention (PCI) for coronary artery disease than men treated with PCI for the same condition, according to research presented today at the ESC Congress 2012.

27 Aug 2012

Female sex associated with increased risk of stroke for AF patients aged ≥75 years

Female gender increases the risk of stroke in patients with atrial fibrillation (AF) aged >75 years by 20%, according to a study presented today at the ESC Congress 2012. The findings were presented by Anders Mikkelsen, from Denmark.

27 Aug 2012

Prasugrel as safe as clopidogrel in preventing heart attack, stroke and death

The first trial to study patients with acute coronary syndrome who do not undergo coronary stenting or bypass surgery found no significant difference between two anti-clotting drugs - prasugrel and clopidogrel - in preventing the first occurrence of death, heart attack or stroke, according to Duke University Medical Center cardiologists.

27 Aug 2012

Trevo Retriever effectively removes blood clots in patients with stroke

Every 40 seconds, someone in the United States has a stroke, usually caused when a clot blocks an artery that supplies blood to the brain. Now the results of two multicenter studies published online in The Lancet on August 26 are giving physicians new innovative tools proven to better remove these clots that block blood flow.

26 Aug 2012

Bleeding risk from aneurysm high in hemorrhagic AVM radiosurgery

In patients undergoing stereotactic radiosurgery for hemorrhagic arteriovenous malformations, endovascular or surgical strategies that reduce bleeding risk should be used if an aneurysm is found, advise US researchers.

24 Aug 2012

Blood clotting treatment algorithms help decrease transfusion requirements in cardiac surgery patients

In patients who undergo cardiac surgery, severe perioperative bleeding and its treatment are often associated with increases in major cardiac and non-cardiac adverse events and greater mortality. A study from the September issue of Anesthesiology determined certain blood clotting treatment algorithms helped decrease blood transfusion requirements in cardiac surgery patients and were associated with improved outcomes and hospital cost-savings.

23 Aug 2012