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New mouse model reveals how Alzheimer's causes dementia

Using a novel, newly developed mouse model that mimics the development of Alzheimer's disease in humans, Johns Hopkins researchers say they have been able to determine that a one-two punch of major biological "insults" must occur in the brain to cause the dementia that is the hallmark of the disease.

4 Jul 2016

Study finds link between copper exposure and prion protein neurotoxicity

Iowa State University researchers have described with single-molecule precision how copper ions cause prion proteins to misfold and seed the misfolding and clumping of nearby prion proteins.

4 Jul 2016

New strategy treats fatal autoimmune disease without outward off-target effects

In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.

4 Jul 2016

Researchers uncover how dysfunction of brain circuit may contribute to memory loss

Two interconnected brain areas - the hippocampus and the entorhinal cortex - help us to know where we are and to remember it later.

30 Jun 2016

Mice studies reveal new insights into neurons that cause symptoms of Rett syndrome

Two studies in mice from Baylor College of Medicine, Texas, reveal new insights into neurons that mediate symptoms typical of the postnatal neurological disorder Rett syndrome.

29 Jun 2016

Study examines role of HOX genes in ovarian cancer resistance

A new UK study has identified a gene signature that predicts poor survival from ovarian cancer. The study also identified genes which help the cancer develop resistance to chemotherapy - offering a new route to help tackle the disease.

28 Jun 2016

Researchers test new drug with potential to reverse or slow progression of asthma

A new drug with the potential to reverse or slow the development of asthma is being tested by researchers at The University of Queensland.

28 Jun 2016

Scientists discover link between two genes involved in PD and autoimmune diseases

A study publish in the journal CELL indicates that two genes associated with Parkinson's disease (PD) are key regulators of the immune system, providing direct evidence linking Parkinson's to autoimmune disease.

27 Jun 2016

New study shows microRNAs play important role in inducing asthma

A new study shows that microRNAs, which are small, noncoding RNA molecules that can silence genes, have an important role in inducing asthma.

24 Jun 2016

New Bruker In-Vivo Xtreme II system accelerates preclinical infectious disease research at University of Lausanne

Bruker’s recently introduced preclinical in vivo imaging system – In-Vivo Xtreme II™– is accelerating the preclinical research into infectious diseases being undertaken at the Institute of Microbiology at the University of Lausanne, Switzerland. Infectious diseases are the second leading cause of death worldwide.

From Bruker BioSpin Division 24 Jun 2016

Scientists elucidate why acute leukemias with same genetic abnormality vary in aggressiveness

Scientists at the Friedrich Miescher Institute for Biomedical Research and the University of Basel have discovered why acute leukemias with the same genetic abnormality vary in their aggressiveness based on their cellular origin.

24 Jun 2016

Lack of Alix protein leads to occurrence of hydrocephalus in the brain

A team led by researchers at St. Jude Children's Research Hospital report that mice lacking the protein Alix develop hydrocephalus or "water on the brain." Alix ensures that epithelial cells of the choroid plexus are oriented correctly with respect to one another to prevent compromise of the epithelial barrier.

23 Jun 2016

Scientists detect new genetic candidate for testing treatments that could influence fear learning in PTSD patients

Researchers at The Saban Research Institute of Children's Hospital Los Angeles have identified a new genetic candidate for testing therapies that might affect fear learning in people with PTSD or other conditions. Results of the study have been published in the Journal of Neuroscience.

22 Jun 2016

Potential therapeutic approaches to combat chronic myeloid leukemia

Chronic myeloid leukemia (CML) develops through chromosomal alterations in blood-forming cells of the bone marrow and usually occurs in older persons. Around 20 percent of adults diagnosed with leukemia suffer from this type of blood cancer.

21 Jun 2016

Scientists aim to explore how gestational diabetes can put babies at lifelong risk for cardiovascular disease

Gestational diabetes can put babies at a lifelong risk for cardiovascular disease, and scientists want to better understand how.

21 Jun 2016

Mother's obesity can impair health of future generations

New research suggests that mothers who eat high-fat, high-sugar diets can predispose multiple generations to metabolic problems, even if their offspring consume healthy diets.

17 Jun 2016

CHLA study provides novel insights into the brain mechanisms linked to Prader-Willi syndrome

A study published in the journal Human Molecular Genetics by researchers at Children's Hospital Los Angeles provides novel insights into the brain mechanisms underlying the insatiable hunger and subsequent obesity in patients with Prader-Willi syndrome.

15 Jun 2016

BNPs have potential to enable early diagnosis, long-term treatment of RA with minimal side effects

The results of a study presented today at the European League Against Rheumatism Annual Congress showed that tiny particles made of a biodegradable polymer (BNPs -- biodegradable polymer nanoparticles) have the potential to enable early detection and efficient long-term treatment of rheumatoid arthritis (RA), with minimal side effects.

10 Jun 2016

Innovative mouse model could provide new strategy to arrest growth of pancreatic cancer

Pancreatic ductal adenocarcinoma, the most common of pancreatic cancers, is extraordinarily lethal, with a 5-year survival rate of just 6 percent. Chemotherapy treatments are poorly effective, in part due to a high degree of drug-resistance to currently used regimens.

7 Jun 2016

HKUST study suggests innate immune response plays vital role in pathogenesis of AD

Alzheimer's disease (AD) is a devastating condition with no known effective treatment. The disease is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD.

7 Jun 2016

Mouse Model News and Research

New mouse model reveals how Alzheimer's causes dementia

Study finds link between copper exposure and prion protein neurotoxicity

New strategy treats fatal autoimmune disease without outward off-target effects

Researchers uncover how dysfunction of brain circuit may contribute to memory loss

Mice studies reveal new insights into neurons that cause symptoms of Rett syndrome

Study examines role of HOX genes in ovarian cancer resistance

Researchers test new drug with potential to reverse or slow progression of asthma

Scientists discover link between two genes involved in PD and autoimmune diseases

New study shows microRNAs play important role in inducing asthma

New Bruker In-Vivo Xtreme II system accelerates preclinical infectious disease research at University of Lausanne

Scientists elucidate why acute leukemias with same genetic abnormality vary in aggressiveness

Lack of Alix protein leads to occurrence of hydrocephalus in the brain

Scientists detect new genetic candidate for testing treatments that could influence fear learning in PTSD patients

Potential therapeutic approaches to combat chronic myeloid leukemia

Scientists aim to explore how gestational diabetes can put babies at lifelong risk for cardiovascular disease

Mother's obesity can impair health of future generations

CHLA study provides novel insights into the brain mechanisms linked to Prader-Willi syndrome

BNPs have potential to enable early diagnosis, long-term treatment of RA with minimal side effects

Innovative mouse model could provide new strategy to arrest growth of pancreatic cancer

HKUST study suggests innate immune response plays vital role in pathogenesis of AD

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