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JQ1 cancer drug may be useful in purging latent HIV infection

Breakthrough drugs have made it possible for people to live with HIV longer than ever before, but more work must be done to actually cure the disease. One of the challenges researchers face involves fully eradicating the virus when it is latent in the body.

30 Nov 2012

Engineers develop simple and inexpensive way to create 3-D brain tissues in lab dishes

Borrowing from microfabrication techniques used in the semiconductor industry, MIT and Harvard Medical School (HMS) engineers have developed a simple and inexpensive way to create three-dimensional brain tissues in a lab dish.

30 Nov 2012

Low-intensity vibrations improve immune function of obese mice

If you're looking to get some of the benefits of exercise without doing the work, here's some good news. A new research report published online in The FASEB Journal shows that low-intensity vibrations led to improvements in the immune function of obese mice.

30 Nov 2012

Cleveland Clinic researcher names American Association for the Advancement of Science Fellow

Cleveland Clinic researcher Jun Qin, Ph.D., has been named a Fellow of the American Association for the Advancement of Science (AAAS). As part of the Molecular Cardiology Department in the Lerner Research Institute, Qin was elected as an AAAS Fellow for exemplary contributions to the field of cell signaling.

30 Nov 2012

DARA BioSciences submits KRN5500 Orphan Drug Application with FDA

DARA BioSciences, Inc., a specialty pharmaceutical company focused on oncology and oncology supportive care products, announced today it has submitted an Orphan Drug Application to the U.S. Food and Drug Administration (FDA) for KRN5500, a compound in development to treat a painful form of chronic chemotherapy-induced peripheral neuropathy (CCIPN).

30 Nov 2012

Novel SIRT2 inhibitor protects against neuronal damage in animal models of Huntington's

Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended survival in two animal models of Huntington's disease.

30 Nov 2012

Scientists define key underlying process implicated in multiple sclerosis

Scientists at the Gladstone Institutes have defined for the first time a key underlying process implicated in multiple sclerosis (MS)-a disease that causes progressive and irreversible damage to nerve cells in the brain and spinal cord. This discovery offers new hope for the millions who suffer from this debilitating disease for which there is no cure.

30 Nov 2012

AstraZeneca receives FDA approval for Cometriq to treat medullary thyroid cancer

The U.S. Food and Drug Administration today approved Cometriq (cabozantinib) to treat medullary thyroid cancer that has spread to other parts of the body (metastasized).

29 Nov 2012

Ponatinib thwarts T315I gene mutation in chronic myeloid leukemia

A previously invincible mutation in chronic myeloid leukemia (CML) has been thwarted by an investigational drug in a phase I clinical trial reported in the current edition of The New England Journal of Medicine.

29 Nov 2012

Combination of blood test and whole-genome sequencing technology could screen cancers

Scientists at the Johns Hopkins Kimmel Cancer Center have combined the ability to detect cancer DNA in the blood with genome sequencing technology in a test that could be used to screen for cancers, monitor cancer patients for recurrence and find residual cancer left after surgery.

29 Nov 2012

University of Cincinnati to lead Belatacept Early Steroid withdrawal Trial

The University of Cincinnati will lead a $5.2 million national trial studying removal of both corticosteroids and common immunosuppression treatments from the post-transplant drug regimen for kidney transplant patients.

29 Nov 2012

Cost increases for branded drugs outpace inflation

U.S. price increases on popular branded drugs in the past year have been more than six times the overall rate of inflation for consumer goods, while spending on specialty medications is up nearly 23 percent, according to data compiled by Express Scripts for its first quarterly drug trend report.

29 Nov 2012

New antifungal drugs could be developed based on substance bacteria use to decompose mushrooms

Soft rot diseases cause a great deal of damage in agriculture, and turn fruits, vegetables, and mushrooms to mush. By using imaging mass spectrometry together with genetic and bioinformatic techniques (genome mining), German researchers have now discovered the substance the bacteria use to decompose mushrooms.

29 Nov 2012

Combining statin treatment with better fitness improves survival in people with dyslipidaemia

Taking statins or being even modestly physically fit markedly improves survival in people with dyslipidaemia (abnormal levels of harmful blood fats/cholesterol), according to new research published Online First in The Lancet. But combining statin treatment with better fitness may do more to ward off death than either intervention alone.

29 Nov 2012

Blood test and gene sequencing combined to detect cancer

29 Nov 2012

Fertility treatment auto-injector: an interview with Lai Chiu Tang, Senior Industrial Designer at Cambridge Consultants

During IVF treatment you will need to take certain drugs. For example, for IVF it will be Follicle Stimulating Hormones (FSH) which are used to stimulate the ovaries to produce a mature egg so that they can be fertilised externally and then put back into the womb.

29 Nov 2012

Suvorexant may bring help for people with insomnia

A new drug may bring help for people with insomnia, according to a study published in the November 28, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology.

29 Nov 2012

Tufts University researchers demonstrate silk-based implantable optics

Tufts University School of Engineering researchers have demonstrated silk-based implantable optics that offer significant improvement in tissue imaging while simultaneously enabling photo thermal therapy, administering drugs and monitoring drug delivery. The devices also lend themselves to a variety of other biomedical functions.

29 Nov 2012

Pharma companies improving access to medicines but lack oversight of outsourced clinical trials, analysis says

Pharmaceutical companies are showing "greater accountability in the boardroom today over access to medicines, with more openness, targets and investment in drugs relevant to the poor," but they "show no evidence that they adequately supervise the conduct of outsourced clinical drug trials, according to a new analysis released on Wednesday," the Financial Times reports.

29 Nov 2012

Review: Omega-3 fatty acids may still help prevent heart disease

Literally hundreds of clinical trials, including some that have gained widespread attention, have been done on the possible benefits of omega-3 fatty acids for the prevention of heart disease - producing conflicting results, varied claims, and frustrated consumers unsure what to believe.

29 Nov 2012

Drugs News and Research

JQ1 cancer drug may be useful in purging latent HIV infection

Engineers develop simple and inexpensive way to create 3-D brain tissues in lab dishes

Low-intensity vibrations improve immune function of obese mice

Cleveland Clinic researcher names American Association for the Advancement of Science Fellow

DARA BioSciences submits KRN5500 Orphan Drug Application with FDA

Novel SIRT2 inhibitor protects against neuronal damage in animal models of Huntington's

Scientists define key underlying process implicated in multiple sclerosis

AstraZeneca receives FDA approval for Cometriq to treat medullary thyroid cancer

Ponatinib thwarts T315I gene mutation in chronic myeloid leukemia

Combination of blood test and whole-genome sequencing technology could screen cancers

University of Cincinnati to lead Belatacept Early Steroid withdrawal Trial

Cost increases for branded drugs outpace inflation

New antifungal drugs could be developed based on substance bacteria use to decompose mushrooms

Combining statin treatment with better fitness improves survival in people with dyslipidaemia

Blood test and gene sequencing combined to detect cancer

Fertility treatment auto-injector: an interview with Lai Chiu Tang, Senior Industrial Designer at Cambridge Consultants

Suvorexant may bring help for people with insomnia

Tufts University researchers demonstrate silk-based implantable optics

Pharma companies improving access to medicines but lack oversight of outsourced clinical trials, analysis says

Review: Omega-3 fatty acids may still help prevent heart disease

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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