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Disabling ItpkB enzyme improves function of Natural Killer cells

Researchers at The Scripps Research Institute (TRSI) are fueling the future of cancer treatment by improving a powerful tool in disease defense: the body's immune system. By revealing a novel but widespread cell signaling process, the scientists may have found a way to manipulate an important component of the immune system into more effectively fighting disease.

29 Nov 2012

Tadalafil may offer therapeutic strategy in patients with Becker muscular dystrophy

Cedars-Sinai Heart Institute researchers have found in an initial clinical trial that a drug typically prescribed for erectile dysfunction or pulmonary hypertension restores blood flow to oxygen-starved muscles in patients with a type of muscular dystrophy that affects males, typically starting in childhood or adolescence.

29 Nov 2012

$ACE-inhibitors, angiotensin receptor blockers can treat heart failure with preserved ejection fraction$

ACE-inhibitors, angiotensin receptor blockers can treat heart failure with preserved ejection fraction

A novel study from Karolinska Institutet in Sweden suggests that commonly used drugs to treat heart failure and high blood pressure may have a wider range of application than earlier known, and also can be used against so called HFPEF - a type of heart failure that until now has been impossible to treat.

29 Nov 2012

Two-route drug combination best for horse joint pain

A combination of systemic nonsteroidal anti-inflammatory drugs plus intrasynovial glucocorticosteroids is superior to either medication alone in improving outcomes for lame horses with perisynovial pain of the metacarpophalangeal joint, report Dutch researchers.

28 Nov 2012

Combination of mixed amphetamine salts and topiramate shows promise for cocaine dependence

Medication development efforts for cocaine dependence have yet to result in an FDA approved treatment. The powerful rewarding effects of cocaine, the profound disruptive impact of cocaine dependence on one's lifestyle, and the tendency of cocaine to attract people who make poor life choices and then exacerbate impulsive behavior all make cocaine a vexing clinical condition.

28 Nov 2012

Researchers discover alternative mechanism for Ras protein activation

The protein Ras plays an important role in cellular growth control. Researchers have focused on the protein because mutations in its gene are found in more than 30 percent of all cancers, making it the most prevalent human oncogene.

28 Nov 2012

Off label atypical antipsychotic use lacks safety and effectiveness in patients over 40

In older adults, antipsychotic drugs are commonly prescribed off-label for a number of disorders outside of their Food and Drug Administration (FDA)-approved indications - schizophrenia and bipolar disorder. The largest number of antipsychotic prescriptions in older adults is for behavioral disturbances associated with dementia, some of which carry FDA warnings on prescription information for these drugs.

28 Nov 2012

Digoxin increases risk of death in patients with atrial fibrillation

Digoxin, a drug widely used to treat heart disease, increases the possibility of death when used by patients with a common heart rhythm problem − atrial fibrillation (AF), according to new study findings by University of Kentucky researchers. The results have been published in the prestigious European Heart Journal, and raises serious concerns about the expansive use of this long-standing heart medication in patients with AF.

28 Nov 2012

Researchers aim to improve feeling of 'walking on marbles' for arthritis patients

Researchers at the University of Southampton are to undertake a new stage of a study aimed at improving the health and mobility of those suffering from the common complaint of 'walking on marbles' associated with Rheumatoid Arthritis (RA) in the feet.

28 Nov 2012

High-resolution real-time images show how nerves may be damaged during earliest stages of MS

High-resolution real-time images show in mice how nerves may be damaged during the earliest stages of multiple sclerosis. The results suggest that the critical step happens when fibrinogen, a blood-clotting protein, leaks into the central nervous system and activates immune cells called microglia.

28 Nov 2012

State roundup: Conn. official says bulk buying prescription drugs could help budget

The state's chief fiscal watchdog is asking legislators and Gov. Dannel P. Malloy's administration to take a second look at how government purchases prescription medication -- and a proposal he believes could save more than $65 million over the next fiscal year.

28 Nov 2012

REEAD technology can diagnose malaria infections with very high sensitivity

Malaria is a life-threatening disease that strikes more than 200 million people every year - mainly in Africa, Asia and Latin America. The disease is caused by the Plasmodium parasite, which is spread by infected mosquito bites. Today, malaria can be prevented and successfully treated, but more than half a million people nevertheless die every year from the disease.

28 Nov 2012

Scientists adapt modern weather prediction techniques to generate local flu outbreak forecasts

Scientists at Columbia University and the National Center for Atmospheric Research have adapted techniques used in modern weather prediction to generate local forecasts of seasonal influenza outbreaks.

28 Nov 2012

Study identifies gene signature associated with resistance to cancer therapies

Agendia, an innovative molecular cancer diagnostics company and leader in personalized medicine, today announced the publication in the November 21st issue of the prestigious scientific journal "Cell" of a study that identifies a gene signature that is associated with resistance to a broad range of cancer therapies in multiple cancer types.

28 Nov 2012

Subthreshold bipolarity common in major depressive disorder

Results from a Polish study show that a substantial proportion of patients with major depressive disorder meet criteria for subthreshold bipolarity.

27 Nov 2012

Kinexus releases new antibody microarray kit

Kinexus Bioinformatics Corporation, a world leader in functional proteomics research, announced today the release of its first Kinex antibody microarray kit with its latest generation KAM-850 chip.

27 Nov 2012

FDA clears Avaxia’s AVX-470 IND for treatment of ulcerative colitis

Avaxia Biologics, Inc., a privately-held biotechnology company developing oral antibody drugs that act locally within the digestive tract, announced today that the US Food and Drug Administration (FDA) has cleared the Investigational New Drug (IND) application for AVX-470 for the treatment of ulcerative colitis.

27 Nov 2012

Orbitofrontal cortex responsible for decisions made on spur of the moment

An area of the brain called the orbitofrontal cortex is responsible for decisions made on the spur of the moment, but not those made based on prior experience or habit, according to a new basic science study from substance abuse researchers at the University of Maryland School of Medicine and the National Institute on Drug Abuse (NIDA). Scientists had previously believed that the area of the brain was responsible for both types of behavior and decision-making.

27 Nov 2012

Liver disease therapies: an interview with Eric Halioua, CEO of Promethera Biosciences

Liver disease is a very broad family of diseases. There are two main categories of liver disease:

27 Nov 2012

New system can predict timing and severity of seasonal influenza outbreaks

Scientists have developed a system to predict the timing and severity of seasonal influenza outbreaks that could one day help health officials and the general public better prepare for them. The system adapts techniques used in modern weather prediction to turn real-time, Web-based estimates of influenza infection into local forecasts of seasonal flu.

27 Nov 2012

Drugs News and Research

Disabling ItpkB enzyme improves function of Natural Killer cells

Tadalafil may offer therapeutic strategy in patients with Becker muscular dystrophy

ACE-inhibitors, angiotensin receptor blockers can treat heart failure with preserved ejection fraction

Two-route drug combination best for horse joint pain

Combination of mixed amphetamine salts and topiramate shows promise for cocaine dependence

Researchers discover alternative mechanism for Ras protein activation

Off label atypical antipsychotic use lacks safety and effectiveness in patients over 40

Digoxin increases risk of death in patients with atrial fibrillation

Researchers aim to improve feeling of 'walking on marbles' for arthritis patients

High-resolution real-time images show how nerves may be damaged during earliest stages of MS

State roundup: Conn. official says bulk buying prescription drugs could help budget

REEAD technology can diagnose malaria infections with very high sensitivity

Scientists adapt modern weather prediction techniques to generate local flu outbreak forecasts

Study identifies gene signature associated with resistance to cancer therapies

Subthreshold bipolarity common in major depressive disorder

Kinexus releases new antibody microarray kit

FDA clears Avaxia’s AVX-470 IND for treatment of ulcerative colitis

Orbitofrontal cortex responsible for decisions made on spur of the moment

Liver disease therapies: an interview with Eric Halioua, CEO of Promethera Biosciences

New system can predict timing and severity of seasonal influenza outbreaks

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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