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DNA damage response contains previously unknown components: Study

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida; Duke University; Johns Hopkins University; the Brazilian National Cancer Institute; and the Rio de Janeiro Federal Institute of Education, Science and Technology have discovered that an intricate system to repair DNA damage called the "DNA damage response" (DDR) contains previously unknown components, including proteins that could be targeted as sensitizers for chemotherapy.

17 Oct 2012

Study: 3 in 10 kidney transplant patients require readmission to hospital within 30 days of discharge

Three in 10 patients receiving a kidney transplant require readmission to the hospital within 30 days of discharge following surgery, according to a Johns Hopkins analysis of six years of national data.

17 Oct 2012

Chloride-restrictive intravenous strategy may decrease incidence of AKI among critically ill patients

In a pilot study assessing the effect of different levels of chloride in intravenous fluids administered to critically ill patients in an intensive care unit, restricting the amount of chloride administration was associated with a significant decrease in the incidence of acute kidney injury and the use of renal replacement therapy, according to a study in the October 17 issue of JAMA.

17 Oct 2012

FGF21 hormone markedly increases life span in mice

A study by UT Southwestern Medical Center researchers finds that a starvation hormone markedly extends life span in mice without the need for calorie restriction.

17 Oct 2012

Additional drugs linked to meningitis outbreak

Food and Drug Administration officials said Monday that more people may be at risk as a result of contaminated drugs made by a Massachusetts compounding pharmacy.

17 Oct 2012

Salk findings on cold virus proteins may spur new cancer treatments

Cold viruses generally get a bad rap----which they've certainly earned----but new findings by a team of scientists at the Salk Institute for Biological Studies suggest that these viruses might also be a valuable ally in the fight against cancer.

17 Oct 2012

Prescription pain medication abuse on the rise among current generation of adolescents

A new study by the University of Colorado Denver reveals that today's adolescents are abusing prescription pain medications like vicodin, valium and oxycontin at a rate 40 percent higher than previous generations.

17 Oct 2012

UnitedHealth's profit jumps 23 percent in third quarter

The raised profit forecast for the nation's largest insurer was attributed to big enrollment boosts in the company's Medicare and Medicaid plans, even as medical costs remained stable despite an improved economy.

17 Oct 2012

NIH honors Scripps Florida postdoctoral fellow with Pathway to Independence Award

The career of Antonio (Tony) Amelio, a postdoctoral fellow in the Department of Cancer Biology at The Scripps Research Institute, has gotten a boost from the National Institutes of Health in the form of a Howard Temin Pathway to Independence Award in Cancer Research.

17 Oct 2012

Novel drug increases survival in animal models exposed to high-dose radiation

A novel drug that mimics a naturally occurring molecule found in coffee and blueberries has been developed to treat radiation exposure. Charles R. Yates, Pharm.D., Ph.D., and colleagues Duane Miller, Ph.D., and Waleed Gaber, Ph.D., from the University of Tennessee Health Science Center and Baylor College of Medicine, show that application of this drug, starting 24 hours after radiation exposure, increases survival in animal models by three-fold compared to placebo.

17 Oct 2012

Patient-reported outcomes should be assessed in comparative effectiveness of cancer treatments

Patient-reported outcomes should be a standard part of evaluating the comparative effectiveness of cancer treatments, according to recommendations put forward by a multi-institution research group.

17 Oct 2012

BioLineRx completes pre-clinical development of BL-8020 for HCV

BioLineRx, a biopharmaceutical development company, announced today that it has successfully completed the pre-clinical development of BL-8020, an orally available, interferon-free treatment for the Hepatitis C virus (HCV), and plans to commence a Phase I/II safety and efficacy study for BL-8020 in Europe during the first quarter of 2013.

17 Oct 2012

Positive results from PROLOR's Rpeg preclinical toxicology study

PROLOR Biotech, Inc. today announced positive results from a preclinical toxicology study designed to assess the safety and tolerability of PROLOR's proprietary long-acting reversible-pegylation technology.

17 Oct 2012

Offering methadone treatment to drug users significantly reduces HIV infection, transmission risk, study shows

Offering methadone treatment to people who use injection drugs "substantially reduces the risk that they will get HIV or give it to anyone else," according to a BMJ study published this month that pools data from studies done in nine countries, the New York Times reports.

17 Oct 2012

Brachyury variation may increase risk of chordoma

A genetic variation possessed by 40% of the population is associated with a five-fold increase in risk for developing chordoma, a cancer that strikes the bones of the skull and spine.

17 Oct 2012

Exercise can help children with ADHD perform better academically

A few minutes of exercise can help children with attention deficit hyperactivity disorder perform better academically, according to a new study led by a Michigan State University researcher.

17 Oct 2012

State roundup: Many states, cities cut retiree health benefit budgets; Feds to decide Georgia's benchmark benefits plan

As cash-strapped U.S. cities and states struggle to address gaping budget holes, a long-honored benefit for public-sector workers has come into the cross-hairs of budget cutters: retiree health insurance. A growing number of states and cities are eliminating or reducing health coverage for retirees, a benefit that has long fallen by the wayside for most private-sector workers.

16 Oct 2012

Nine Sydney researchers to receive funding for biomedical research projects

The Ramaciotti Foundations will award nearly $645,000 in grants to nine Sydney researchers at a gala dinner tonight, to support continued outstanding biomedical research. The Ramaciotti Foundations will award over $1.6 million to 23 recipients at the annual awards evening in Brisbane.

16 Oct 2012

Mephedrone and memory loss: an interview with Craig Motbey

Mephedrone is a fairly new designer drug which has been around for a few years. It exploded in popularity in Europe (and particularly in the UK) before it started to spread in a major way elsewhere.

16 Oct 2012

Antipsychotic drug exposure may have neurologic consequences

French researchers report an increased risk for Parkinson’s disease in elderly people who have past exposure to neuroleptic drugs.

16 Oct 2012

Drugs News and Research

DNA damage response contains previously unknown components: Study

Study: 3 in 10 kidney transplant patients require readmission to hospital within 30 days of discharge

Chloride-restrictive intravenous strategy may decrease incidence of AKI among critically ill patients

FGF21 hormone markedly increases life span in mice

Additional drugs linked to meningitis outbreak

Salk findings on cold virus proteins may spur new cancer treatments

Prescription pain medication abuse on the rise among current generation of adolescents

UnitedHealth's profit jumps 23 percent in third quarter

NIH honors Scripps Florida postdoctoral fellow with Pathway to Independence Award

Novel drug increases survival in animal models exposed to high-dose radiation

Patient-reported outcomes should be assessed in comparative effectiveness of cancer treatments

BioLineRx completes pre-clinical development of BL-8020 for HCV

Positive results from PROLOR's Rpeg preclinical toxicology study

Offering methadone treatment to drug users significantly reduces HIV infection, transmission risk, study shows

Brachyury variation may increase risk of chordoma

Exercise can help children with ADHD perform better academically

State roundup: Many states, cities cut retiree health benefit budgets; Feds to decide Georgia's benchmark benefits plan

Nine Sydney researchers to receive funding for biomedical research projects

Mephedrone and memory loss: an interview with Craig Motbey

Antipsychotic drug exposure may have neurologic consequences

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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