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Intensive treatment with high doses of statin drugs shows promise for dyslipidemia

A comprehensive new review on how to treat high cholesterol and other blood lipid problems suggests that intensive treatment with high doses of statin drugs is usually the best approach.

16 Oct 2012

First Edition: October 16, 2012

Today's early morning highlights from the major news organizations, including reports about a study regarding the possible impact of premium support on Medicare premiums.

16 Oct 2012

LRRK2 inhibitors may provide neuroprotection for patients with Parkinson's

For decades, patients with Parkinson's disease (PD) have had the same experience. Their hands start to shake uncontrollably, their limbs become rigid and they lose their balance. Years before those movement problems set in, many begin struggling with fainting, incontinence, sexual dysfunction, anxiety and depression. Many patients are still treated with a 42-year-old drug called L-DOPA, which temporarily staves off symptoms but can itself cause heart arrhythmias, stomach bleeding and hallucinations.

16 Oct 2012

Maryland scientists create stem cell model for Gaucher disease

A new method of using adult stem cells as a model for the hereditary condition Gaucher disease could help accelerate the discovery of new, more effective therapies for this and other conditions such as Parkinson's, according to new research from the University of Maryland School of Medicine.

16 Oct 2012

Hepatitis C rapid and point of care tests highly accurate and reliable

Timely screening and diagnosis is critical to the success of new treatments and ultimately to the survival of hepatitis C patients. A new study led by the Research Institute of the McGill University Health Centre (RI MUHC) is the first to show that hepatitis C rapid and point of care tests with a quick turnaround time are highly accurate and reliable as conventional first-line laboratory tests.

16 Oct 2012

Higher health care premiums could wipe out social security increases; Medicare enrollment begins

Social Security recipients shouldn't expect a big increase in monthly benefits come January. Preliminary figures show the annual benefit boost will be between 1% and 2%, which would be among the lowest since automatic adjustments were adopted in 1975.

16 Oct 2012

Thymic stromal lymphopoietin molecule makes mice resistant to skin cancer

A molecule involved in asthma and allergies has now been shown to make mice resistant to skin cancer, according to scientists at Washington University School of Medicine in St. Louis.

16 Oct 2012

GILZ protein encourages bone growth in mouse model

Georgia Health Sciences University researchers have developed a mouse that errs on the side of making bone rather than fat, which could eventually lead to better drugs to treat inflammatory diseases such as rheumatoid arthritis.

16 Oct 2012

Rapamycin may delay onset of Parkinson's or AD

Rapamycin, a drug used to prevent rejection in transplants, could delay the onset of neurodegenerative diseases such as Alzheimer's and Parkinson's.

16 Oct 2012

Physicians urged to think twice before they prescribe compounded drugs

The recent outbreak of meningitis in the US-and the subsequent deaths of 15 individuals-has renewed scrutiny on the contemporary practice of pharmacy compounding. The risks to patients, and associated liability risk to prescribing physicians, largely outweigh the benefits when the practice goes beyond the traditional, extemporaneous role, according to Sarah Sellers from q-Vigilance LLC and Wulf Utian from Case Western Reserve University in the US. Sellers and Utian's opinion piece appears online in the journal Drugs, published by Adis.

16 Oct 2012

Cannabis and the endocannabinoid system: an interview with Dr Leonora Long

Cannabis has both physical and behavioural effects. People using cannabis can experience feelings of euphoria (well-being), hunger, sleepiness, problems with motor coordination, and sometimes feelings of anxiety and paranoia.

15 Oct 2012

Statins could be first preventive treatment for liver cancer

Statins may reduce the risk for hepatocellular carcinoma, show the results of a meta-analysis.

15 Oct 2012

Obesity does not affect VTE risk after knee surgery

Being morbidly obese does not increase the risk for developing venous thromboembolism after total knee arthroplasty surgery, report US researchers.

15 Oct 2012

Private negotiations over Trans-Pacific Partnership agreement conclude

Negotiators from the United States and 10 other countries last month concluded a 14th round of private talks in Leesburg, Va., "to wrap up the Trans-Pacific Partnership, poised to become the largest trade deal in U.S. history," the Charlotte Observer reports.

15 Oct 2012

Questions abound on compounding pharmacies after meningitis outbreak

Compounding pharmacies continue to face intense scrutiny over their drug preparation and lobbying habits after one in Massachusetts is suspected in distributing a steroid that led to a meningitis outbreak.

15 Oct 2012

Maryland professor receives 2012 Distinguished Service Award from AAPS

Larry Augsburger, PhD, professor emeritus at the University of Maryland School of Pharmacy, has received the 2012 Distinguished Service Award of the American Association of Pharmaceutical Scientists (AAPS), one of the highest honors bestowed by the group of 12,000 members in more than 70 countries.

15 Oct 2012

Abertay lecture to reveal how computer games can help discover new drugs for cancer

How can computer games technology help discover new drugs to treat cancer? This surprising step forward for science will be revealed at a free public lecture at the University of Abertay Dundee this Wednesday at 6pm.

15 Oct 2012

More Medicare Advantage Plans get top ratings

Privately-run health insurance companies that contract with Medicare are scoring higher in a government-backed quality rating system designed to guide seniors to better medical care choices and service, the Obama administration announced Friday. The so-called "Medicare Advantage Plans" are performing better with more of them hitting four- and five-star ratings on the five-star scale, said U.S. Secretary for Health and Human Services Kathleen Sebelius and officials from the Centers for Medicare and Medicaid Services.

15 Oct 2012

Study evaluates international data on kidney transplantation

Kidney transplants performed in Europe are considerably more successful in the long run than those performed in the United States.

15 Oct 2012

Database of drug-induced liver injury now available from NIH

A free source of evidence-based information for health care professionals and for researchers studying liver injury associated with prescription and over-the-counter drugs, herbals, and dietary supplements is now available from the National Institutes of Health. Researchers and health care professionals can use the LiverTox database to identify basic and clinical research questions to be answered and to chart optimal ways to diagnose and control drug-induced liver injury.

15 Oct 2012