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UNC-Chapel Hill pharmacy researchers use skin cells to destroy brain tumors

In a first for medical science, University of North Carolina at Chapel Hill pharmacy researchers turn skin cells into cancer-hunting stem cells that destroy brain tumors known as glioblastoma - a discovery that can offer, for the first time in more than 30 years, a new and more effective treatment for the disease.

25 Feb 2016

New study allows researchers to see how insulin in islets responds to sugar

"Scientists and doctors have wanted to know how much insulin a person has in their body, but haven't been able to know the exact amount without the patient being deceased and actually removing the pancreas," says Peter Arvan, division chief of Metabolism, Endocrinology & Diabetes at the University of Michigan.

25 Feb 2016

Study provides pathways to understand complex neurological disorders

Scientists have now described the engineering of a bright red fluorescent protein-based voltage indicator, providing pathways to understanding complex neurological disorders. Designated as FlicR1 (fluorescent indicator for voltage imaging red), these indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution.

25 Feb 2016

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, eventually causing cell death by lysis - the lytic phase.

25 Feb 2016

Scientists reveal underlying mechanism for formation and growth of epithelial tubes

A team of scientists from Singapore and France has revealed the underlying mechanism for the formation and growth of a fundamental type of tissue - epithelial tubes. Defects in the architecture of epithelial tubes lead to diseases such as cholestasis, atherosclerosis and polycystic kidney disease.

25 Feb 2016

Ground-breaking discovery could lead to new treatments for diabetes

Why would a bacteria-killing protein be present in an area of the body that is not normally exposed to bacteria, like the pancreas? Researchers at The Ottawa Hospital and the University of Ottawa puzzled over this question for some time, until they eventually discovered that the protein in question was doing something entirely unexpected - it was actually helping the pancreas regenerate and produce insulin.

25 Feb 2016

Frontotemporal dementia often misdiagnosed as Alzheimer’s disease in many patients

Many patients showing signs of dementia are quickly diagnosed with Alzheimer's disease when they might actually suffer from frontotemporal dementia, delaying the appropriate treatment for them.

25 Feb 2016

Gene expression analysis points metastatic CRC patient to successful irbesartan therapy

A patient with recurrent metastatic colorectal cancer has been successfully treated with the angiotensin receptor blocker irbesartan, researchers report.

24 Feb 2016

Researchers launch clinical trials to test novel cellular-immunotherapy to treat three types of blood cancer

Cancer immunology is based upon boosting the body's own immune system to vanquish malignancies. It is among the fastest growing areas of oncology research. Researchers at UC San Diego Moores Cancer Center have launched three clinical trials to test the safety and efficacy of a novel cellular-immunotherapy that uses modified T cells - one of the immune system's primary weapons - to treat three different types of blood cancer that often defy existing therapies.

24 Feb 2016

Ohio State researchers develop new approach to enhance heart function, cardiovascular performance

For the first time, scientists at The Ohio State University have engineered new calcium receptors for the heart to tune the strength of the heartbeat in an animal model. The research is published online by the journal Nature Communications.

24 Feb 2016

Immunotherapy emerges as promising strategy for treatment of brain tumors

For decades most cancers have been treated with a core standard of treatments that include surgery, radiation, and chemotherapy. Now, immunotherapy—a type of treatment that harnesses the patient's immune system to combat the disease—represents the future of cancer treatment, with its efficacy being demonstrated in even the most aggressive types of cancer.

24 Feb 2016

New clinical trial launched to test potential drug that could help immune system combat cancer

Cancer Research UK's Centre for Drug Development, in partnership with Amgen Inc., has launched a new clinical trial to test a drug that could stop a patient's immune system from protecting tumours.

24 Feb 2016

Food-based proteins can help address child malnutrition in developing countries

Contrary to popular belief among world relief workers, children in developing countries may not be eating enough protein, which could contribute to stunted growth, a Johns Hopkins-directed study suggests.

24 Feb 2016

Study reveals role of 'Kurly' protein found in cilia

A new study of a protein found in cilia - the hair-like projections on the cell surface - may help explain how genetic defects in cilia play a role in developmental abnormalities, kidney disease and a number of other disorders.

24 Feb 2016

UEA research paves way for new wave of drugs to kill superbugs

Scientists at the University of East Anglia are getting closer to solving the problem of antibiotic resistance.

24 Feb 2016

Inadequate dietary intake of essential amino acids and nutrient choline linked to stunting

Worldwide, an estimated 25 percent of children under age 5 suffer from stunted growth and development. The most visible characteristic is short stature, but the effects of stunting are far more profound: The condition prevents children from reaching their cognitive potential; makes them more susceptible to illness and infection; and shortens their life spans.

24 Feb 2016

SOM0226 (tolcapone) drug could significantly improve pharmacological treatment of ATTR

Researchers at the Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona (IBB-UAB), in collaboration with the biopharmaceutical company SOM Biotech, located in the Barcelona Science Park (PCB), have published, in Nature Communications, the results of a drug repositioning study in which they describe a powerful drug, SOM0226 (tolcapone) that could significantly improve the pharmacological treatment of familial transthyretin amyloidosis (ATTR).

24 Feb 2016

New study identifies cell communication mechanism

The cells of an organism interact not only with each other but with the extracellular matrix that surrounds them. Increasing evidence is unveiling the relevance of this structure--which is secreted by the cells themselves-- for the correct function of the organism and also for the development of various diseases.

24 Feb 2016

Influenza virus can able to circumvent the body's immune system

Influenza is able to mask itself, so that the virus is not initially detected by our immune system. This is the result of new research from Aarhus University. The researchers behind the study hope that the discovery can be used to develop better treatment against influenza and chronic inflammation conditions such as rheumatoid arthritis.

24 Feb 2016

Immune cells may play greater role in Alzheimer's disease than originally thought

Immune cells that normally help us fight off bacterial and viral infections may play a far greater role in Alzheimer's disease than originally thought, according to University of California, Irvine neurobiologists with the Sue & Bill Gross Stem Cell Research Center and the Institute for Memory Impairments and Neurological Disorders.

24 Feb 2016

G Protein News and Research

UNC-Chapel Hill pharmacy researchers use skin cells to destroy brain tumors

New study allows researchers to see how insulin in islets responds to sugar

Study provides pathways to understand complex neurological disorders

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Scientists reveal underlying mechanism for formation and growth of epithelial tubes

Ground-breaking discovery could lead to new treatments for diabetes

Frontotemporal dementia often misdiagnosed as Alzheimer’s disease in many patients

Gene expression analysis points metastatic CRC patient to successful irbesartan therapy

Researchers launch clinical trials to test novel cellular-immunotherapy to treat three types of blood cancer

Ohio State researchers develop new approach to enhance heart function, cardiovascular performance

Immunotherapy emerges as promising strategy for treatment of brain tumors

New clinical trial launched to test potential drug that could help immune system combat cancer

Food-based proteins can help address child malnutrition in developing countries

Study reveals role of 'Kurly' protein found in cilia

UEA research paves way for new wave of drugs to kill superbugs

Inadequate dietary intake of essential amino acids and nutrient choline linked to stunting

SOM0226 (tolcapone) drug could significantly improve pharmacological treatment of ATTR

New study identifies cell communication mechanism

Influenza virus can able to circumvent the body's immune system

Immune cells may play greater role in Alzheimer's disease than originally thought

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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