Mouse Model News and Research

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Unique mouse model could help study genetic origins and potential treatments for ALS

University of Florida Health researchers have developed a unique mouse model that will allow researchers around the world to better study the genetic origins and potential treatments for a neurodegenerative brain disease that causes amyotrophic lateral sclerosis, often referred to as ALS or Lou Gehrig's disease, and frontotemporal dementia.

22 Apr 2016

PPP3CA, calcineurin may be suitable therapeutic targets for multiple myeloma treatment

Multiple myeloma (MM) is a hematological cancer that frequently acquires resistance to chemotherapeutic drugs. Additionally, many patients experience disease relapse, but these patients are difficult to treat as the cancer is often resistant to the previous treatment regimen.

22 Apr 2016

Infected mice can be better models for human diseases

Vaccines and therapeutics developed using mice often don't work as expected in humans. New research at Washington University School of Medicine in St. Louis points to the near-sterile surroundings of laboratory mice as a key reason.

21 Apr 2016

SI-2 molecule can inhibit tumor growth in breast cancer mouse model

Cancer cells communicate with their environment through cell molecules that pass on signals to the inside of the cell. The signals help cancer cells multiply and migrate, spreading the disease.

21 Apr 2016

New mouse model to aid in development of antiviral compounds, vaccines against Zika virus

Researchers at the University of Wisconsin-Madison School of Veterinary Medicine have developed one of the first mouse models for the study of Zika virus. The model will allow researchers to better understand how the virus causes disease and aid in the development of antiviral compounds and vaccines.

20 Apr 2016

Study shows pulmonary alveolar proteinosis can be cured by single transfer of monocytes

Researchers from VIB-UGent reveal that adult circulating monocytes that get access to the macrophage niche in the liver or the lung can acquire identical tissue-specific macrophage functions and self-maintenance capacities as macrophages of embryonic origin.

20 Apr 2016

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

Asthma is an enormous public health problem that continues to grow larger, in part because scientists don't fully understand how it is caused. Existing therapies don't cure the disease and often don't even significantly alleviate the symptoms. Now, scientists from the Perelman School of Medicine at the University of Pennsylvania and Rutgers University have identified a biological pathway that potentially explains why current asthma therapies don't work well in many cases—and might be targeted to help those patients.

19 Apr 2016

Mouse model can help identify new, more effective melanoma-preventing agents

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet-B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. This data suggest that the mouse model can be used to identify new, more effective melanoma-preventing agents, according to principal investigator Christin Burd, PhD.

18 Apr 2016

Mouse model offers insight into molecular, neurological basis of stuttering

Mice that vocalize in a repetitive, halting pattern similar to human stuttering may provide insight into a condition that has perplexed scientists for centuries, according to a new study by researchers at Washington University School of Medicine in St. Louis and the National Institutes of Health.

16 Apr 2016

Palovarotene drug may prevent multiple musculoskeletal problems linked with FOP

New research in laboratory animals suggests that the drug palovarotene may prevent multiple skeletal problems caused by a rare but extremely disabling genetic bone disease, and may even be a candidate for use in newborn babies with the condition.

15 Apr 2016

Combination of genetic, environmental risk factors can trigger fatal eating disorder in humans

In a new study, researchers from Columbia University Medical Center described a new mouse model featuring a combination of genetic and environmental risk factors that can trigger the compulsive restriction of food intake seen in patients with anorexia nervosa. The findings may help to identify new prevention and treatment strategies for the eating disorder in humans.

12 Apr 2016

Increased expression of VEGF-A promotes three common aging-related eye conditions

A Massachusetts General Hospital investigator has found that increased expression of the angiogenic factor VEGF-A promotes three common aging-related eye conditions - both versions of age-related macular degeneration (AMD) and also cataracts - in an animal model.

12 Apr 2016

Research suggests new pathway for preventing optic nerve damage in KPro recipients

Researchers from Massachusetts Eye and Ear/Harvard Medical School have identified inflammatory factors that cause optic neuropathy in the back of the eye following implantation of a keratoprosthesis (KPro) — similar to what glaucoma patients experience, without the rise of pressure in the eye — and have shown that blocking one of those factors, tumor necrosis factor alpha (TNFa), successfully halts the development of optic nerve damage in a mouse model.

11 Apr 2016

Mouse-based study shows exercise decreases cancer incidence, slows tumor growth

When you're pounding along an icy pavement or sweating through a gym workout, you try to remind yourself of the many health benefits of exercise. Between gasps, you can say that a healthy, fit lifestyle helps prevents obesity, a worldwide problem of increasing magnitude that has been linked to cardiovascular disease and diabetes.

11 Apr 2016

Chemists design set of molecules that promote microscopic, anatomical changes in neurons

Chemists at the University of California San Diego have designed a set of molecules that promote microscopic, anatomical changes in neurons associated with the formation and retention of memories. These drug candidates also prevent deterioration of the same neuronal structures in the presence of amyloid-beta, a protein fragment that accumulates in the brains of people with Alzheimer's disease.

11 Apr 2016

Salk scientists identify specific cellular switches that clear dying, dead neurons

By adolescence, your brain already contains most of the neurons that you'll have for the rest of your life. But a few regions continue to grow new nerve cells--and require the services of cellular sentinels, specialized immune cells that keep the brain safe by getting rid of dead or dysfunctional cells.

7 Apr 2016

Compound from unique blue-green algae could be key to next anti-cancer drug

Could a slippery glob of algae hold the key to the next anti-cancer drug? According to new research into a compound produced by a unique community of blue-green algae, the answer could be yes.

7 Apr 2016

Researchers develop mouse model for testing vaccines, therapeutics to battle Zika virus

A research team at Washington University School of Medicine in St. Louis has established a mouse model for testing of vaccines and therapeutics to battle Zika virus.

6 Apr 2016

Study shows how Down Syndrome gene associated with altered oscillations in the cerebral cortex

Cerebral activity is governed by a fine balance between neuronal excitation and inhibition. Specifically, neurons are activated by excitation mechanisms tightly regulated by inhibition processes. For certain functions, the neuronal network needs to be synchronized.

6 Apr 2016

Immune cell with 'Superman' power could lead to novel therapies for type 1 diabetes

A new study led by scientists at The Scripps Research Institute (TSRI) reveals a previously unknown type of immune cell. The discovery opens new avenues in the effort to develop novel therapies for autoimmune diseases such as type 1 diabetes.

6 Apr 2016

Mouse Model News and Research

Unique mouse model could help study genetic origins and potential treatments for ALS

PPP3CA, calcineurin may be suitable therapeutic targets for multiple myeloma treatment

Infected mice can be better models for human diseases

SI-2 molecule can inhibit tumor growth in breast cancer mouse model

New mouse model to aid in development of antiviral compounds, vaccines against Zika virus

Study shows pulmonary alveolar proteinosis can be cured by single transfer of monocytes

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

Mouse model can help identify new, more effective melanoma-preventing agents

Mouse model offers insight into molecular, neurological basis of stuttering

Palovarotene drug may prevent multiple musculoskeletal problems linked with FOP

Combination of genetic, environmental risk factors can trigger fatal eating disorder in humans

Increased expression of VEGF-A promotes three common aging-related eye conditions

Research suggests new pathway for preventing optic nerve damage in KPro recipients

Mouse-based study shows exercise decreases cancer incidence, slows tumor growth

Chemists design set of molecules that promote microscopic, anatomical changes in neurons

Salk scientists identify specific cellular switches that clear dying, dead neurons

Compound from unique blue-green algae could be key to next anti-cancer drug

Researchers develop mouse model for testing vaccines, therapeutics to battle Zika virus

Study shows how Down Syndrome gene associated with altered oscillations in the cerebral cortex

Immune cell with 'Superman' power could lead to novel therapies for type 1 diabetes

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