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Autoimmune disease myasthenia gravis halted in mice

Working with mice, Johns Hopkins researchers say they have developed a gene-based therapy to stop the rodent equivalent of the autoimmune disease myasthenia gravis by specifically targeting the destructive immune response the disorder triggers in the body.

1 Oct 2012

Clinical need, effectiveness, fairness should drive drugs allocation

A policy that is transparent, fair to patients and healthcare providers, and is based on clinical need is an ethically justifiable approach to rationing drugs that are in critically short supply, report researchers.

1 Oct 2012

Regional, seasonal variation in US antibiotic use highlights persisting issue

US study results reveal “substantial” quarterly and regional variation in outpatient antibiotic use among older adults, indicating the possible need for targeted programs to reduce unnecessary prescriptions.

1 Oct 2012

Study opens new door to more personalized treatment of advanced breast cancer

For the first time, researchers have conducted a large trial in which they tested the entire genome of individual breast cancers to help personalize treatment. They released their findings at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.

1 Oct 2012

Emergency medicine residency programs need more formal stroke training

Medical residents training to work in the emergency department need more formal stroke training, says a study presented today at the Canadian Stroke Congress, noting that, as the first point of contact in stroke care, they see nearly 100 per cent of stroke patients taken to hospital.

1 Oct 2012

Researchers track spread of human invasive non-Typhoidal Salmonella in sub-Saharan Africa

A new study out today (Sunday 30 September) reveals that the emergence and spread of a rapidly evolving invasive intestinal disease, that has a significant mortality rate (up to 45%) in infected people in sub-Saharan Africa, seems to have been potentiated by the HIV epidemic in Africa.

1 Oct 2012

Combination of dabrafenib and trametinib delays development of treatment resistance in MM patients

Combined treatment with two drugs targeting different points in the same growth-factor pathway delayed the development of treatment resistance in patients with BRAF-positive metastatic malignant melanoma.

1 Oct 2012

Crizotinib effectively treats patients with ALK-positive lung cancer

The results of a new phase III trial show that crizotinib, a targeted therapy, is a more effective treatment than standard chemotherapy for patients with advanced, ALK-positive lung cancer, researchers said at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.

1 Oct 2012

New trial results on pazopanib and temsirolimus have important implications for patients with RCC

New results from phase III trials exploring treatment options for patients with advanced renal cell carcinoma were released at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.

1 Oct 2012

HR status defines two different subsets of HER2 positive cancers

Human epidermal growth factor (HER2) positive breast cancers are often treated with the same therapy regardless of hormone receptor status. New research published in BioMed Central's open access journal Breast Cancer Research shows that women whose HER2 positive cancer was also hormone (estrogen and progesterone) receptor (HR) negative had an increased risk of early death, and that their cancer was less likely to recur in bone than those whose cancer retained hormone sensitivity.

1 Oct 2012

Study finds differences and similarities between iPSCs and cancer cells

UC Davis investigators have found new evidence that a promising type of stem cell now being considered for a variety of disease therapies is very similar to the type of cells that give rise to cancer. The findings suggest that although the cells -- known as induced pluripotent stem cells (iPSCs) -- show substantial promise as a source of replacement cells and tissues to treat injuries, disease and chronic conditions, scientists and physicians must move cautiously with any clinical use because iPSCs could also cause malignant cancer.

29 Sep 2012

Sorafenib does not improve overall survival among patients with NSCLC

Treatment with the drug sorafenib as a third or fourth line therapy does not result in improved overall survival among patients with advanced non-small cell lung cancer (NSCLC), according to findings released at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna. However, a post-hoc biomarker analysis of the trial data that was also presented suggests that patients with EGFR-mutant tumors may benefit.

29 Sep 2012

Counterfeit drugs for sale: FDA issues warning regarding online pharmacies

The Food and Drug Administration is warning U.S. consumers that the vast majority of Internet pharmacies are fraudulent and likely are selling counterfeit drugs that could harm them.

29 Sep 2012

Drug combinations show promise against metastatic melanoma

Promising new data on drug combinations to treat metastatic melanoma are presented at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.

29 Sep 2012

New studies reveal real economic and human costs of caring for cancer patients in Europe

New studies that reveal for the first time the real economic and human costs of caring for cancer patients in Europe will be presented during the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.

29 Sep 2012

FDA launches campaign to raise public awareness on prevalence of fraudulent Internet pharmacies

The U.S. Food and Drug Administration today launched a national campaign to raise public awareness about the prevalence of fraudulent Internet pharmacies, which can be dangerous to patient health, and to help consumers make safe purchases.

29 Sep 2012

Seattle conference to focus on trauma and addiction treatment

The incidence of trauma and abuse has truly reached epidemic proportions, and those who suffer trauma sometimes turn to alcohol or other drugs to manage post-traumatic stress symptoms like nightmares, anxiety, insomnia, and dissociation.

29 Sep 2012

Research roundup: Saving money with hospital observation units, total knee replacement rates skyrocketing, Medicare patients and antibiotic overuse

The authors write: Using observation units in hospitals to provide care to certain patients can be more efficient than admitting them to the hospital and can result in shorter lengths-of-stay and lower costs. However, such units are present in only about one-third of US hospitals.

29 Sep 2012

Tianyin Pharmaceutical sales decrease 26.9% to $69.6 million for fiscal year 2012

Tianyin Pharmaceutical Inc., a pharmaceutical company that specializes in the patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded generics and active pharmaceutical ingredients (API) announced financial results for the fiscal year 2012.

28 Sep 2012

Cholesterol precursor suppresses inflammatory response genes, causes atherosclerosis

Atherosclerosis - the hardening of arteries that is a primary cause of cardiovascular disease and death - has long been presumed to be the fateful consequence of complicated interactions between overabundant cholesterol and resulting inflammation in the heart and blood vessels.

28 Sep 2012

Drugs News and Research

Autoimmune disease myasthenia gravis halted in mice

Clinical need, effectiveness, fairness should drive drugs allocation

Regional, seasonal variation in US antibiotic use highlights persisting issue

Study opens new door to more personalized treatment of advanced breast cancer

Emergency medicine residency programs need more formal stroke training

Researchers track spread of human invasive non-Typhoidal Salmonella in sub-Saharan Africa

Combination of dabrafenib and trametinib delays development of treatment resistance in MM patients

Crizotinib effectively treats patients with ALK-positive lung cancer

New trial results on pazopanib and temsirolimus have important implications for patients with RCC

HR status defines two different subsets of HER2 positive cancers

Study finds differences and similarities between iPSCs and cancer cells

Sorafenib does not improve overall survival among patients with NSCLC

Counterfeit drugs for sale: FDA issues warning regarding online pharmacies

Drug combinations show promise against metastatic melanoma

New studies reveal real economic and human costs of caring for cancer patients in Europe

FDA launches campaign to raise public awareness on prevalence of fraudulent Internet pharmacies

Seattle conference to focus on trauma and addiction treatment

Research roundup: Saving money with hospital observation units, total knee replacement rates skyrocketing, Medicare patients and antibiotic overuse

Tianyin Pharmaceutical sales decrease 26.9% to $69.6 million for fiscal year 2012

Cholesterol precursor suppresses inflammatory response genes, causes atherosclerosis

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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