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Study identifies USP15 as a critical protein in cancer

After years studying the molecular bases of glioblastoma - the most common brain tumor and one of the most aggressive of all cancers, the group led by Dr. Joan Seoane , Director of Translational Research at the Vall d'Hebron Institute of Oncology (VHIO) and ICREA Research Professor has today published a study in Nature Medicine identifying USP15 as a critical protein in cancer which, thanks to its molecular characteristics, shows enormous therapeutic promise.

20 Feb 2012

Defects in GPR120 protein may lead to obesity and liver disease

Defects in a protein that functions as a dietary fat sensor may be a cause of obesity and liver disease, according to a study published in the journal Nature, led by researchers at Imperial College London. The findings highlight a promising target for new drugs to treat obesity and metabolic disorders.

19 Feb 2012

Researchers discover class of proteins that detect 'painful touch'

In two landmark papers in the journal Nature this week, scientists at The Scripps Research Institute report that they have identified a class of proteins that detect "painful touch."

19 Feb 2012

Protein fragments from yellow field pea seeds can lower blood pressure

There are lots of new ideas out there for giving you extra protection against chronic diseases through the food you eat. But many good ideas may never make it to market. Researchers at the University of Guelph, led by Brian McBride, have found a way to enrich milk with docosahexaeonic acid (DHA)-an essential nutrient that many people are lacking.

19 Feb 2012

The 'nutritional magic' behind soy's heart health benefits

Nutrition science has regarded soy as a superfood with many health benefits for decades. In fact, "25 grams of soy protein per day, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease," according to the FDA.

18 Feb 2012

Scientists discover the off signal for inflammation

Proteins, the building block for all living organisms, are the ultimate transformers - able to splice and switch roles and functions within the human body. But when these changes go wrong, diseases such as cancers and arthritis may result, says University of British Columbia researcher Chris Overall.

18 Feb 2012

TRANSFUSION publishes positive results from CryoStor collaborative research

BioLife Solutions, Inc., a leading developer, manufacturer and marketer of proprietary clinical grade hypothermic storage and cryopreservation freeze media for cells and tissues, today announced that TRANSFUSION, the foremost publication in the world for new information regarding transfusion medicine, has published a peer-reviewed journal article reporting positive results of collaborative research on CryoStor, BioLife's serum-free, protein-free cryopreservation freeze media.

18 Feb 2012

RAD51 gene behind the cause of congenital mirror movements

Further work carried out on mice suggests that this gene plays a part in motor network cross-over. Cross-over is a key factor in the transmission of brain signals, because it allows the right side of the brain to control the left side of the body and vice versa. This research has been published in The American Journal of Human Genetics.

18 Feb 2012

Study reveals immune mechanism for surveillance over EBV infection

Some 90 percent of people are exposed to the Epstein Barr virus (EBV) at some point in their life. Even though it is quickly cleared from the body, the virus can linger silently for years in small numbers of infected B cells.

18 Feb 2012

Scientists observe maturation of immune cells in live zebrafish embryos

T-cells are the immune system's security force. They seek out pathogens and rogue cells in the body and put them out of action. Their precursors are formed in the bone marrow and migrate from there into the thymus. Here, they mature and differentiate to perform a variety of tasks. Scientists at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have now succeeded for the first time in observing the maturation of immune cells in live zebrafish embryos.

17 Feb 2012

Scientists discover molecular pathway by which maternally inherited deafness appears to occur

Yale scientists have discovered the molecular pathway by which maternally inherited deafness appears to occur: Mitochondrial DNA mutations trigger a signaling cascade, resulting in programmed cell death.

17 Feb 2012

Study describes how multiple RNA binding proteins cooperatively control genetic splicing code

Understanding how RNA binding proteins control the genetic splicing code is fundamental to human biology and disease - much like editing film can change a movie scene. Abnormal variations in splicing are often implicated in cancer and genetic neurodegenerative disorders.

17 Feb 2012

Scientists create first 3-D living tissue model of glioma

Brown University scientists have created the first three-dimensional living tissue model, complete with surrounding blood vessels, to analyze the effectiveness of therapeutics to combat brain tumors. The 3-D model gives medical researchers more and better information than Petri dish tissue cultures.

17 Feb 2012

IKK2 enzyme plays a key role in proliferation of lung cancer cells

Drugs targeting an enzyme involved in inflammation might offer a new avenue for treating certain lung cancers, according to a new study by scientists at the Salk Institute for Biological Studies.

17 Feb 2012

First accurate predictive model to differentiate between dengue fever and dengue hemorrhagic fever

Researchers at the University of Texas Medical Branch have developed the first accurate predictive model to differentiate between dengue fever (DF) and its more severe form, dengue hemorrhagic fever (DHF).

17 Feb 2012

Synthetic Oct4 protein more effective at turning genes into pluripotent stem cells

Scientists have found a way to generate and maintain stem cells much more efficiently by amplifying the effect of an essential protein.

17 Feb 2012

New details about how cell signalling is controlled in immune system

Walter and Eliza Hall Institute scientists have revealed new details about how cell signalling is controlled in the immune system, identifying in the process potential new therapeutic targets for treating severe blood disorders.

17 Feb 2012

Amylin may lead to severe heart damage in obese and diabetic patients

Severe heart damage in people who are obese and diabetic is linked with a pancreatic hormone called amylin, UC Davis researchers have found.

17 Feb 2012

Exposure to common flame retardant may affect fertility and long-term memory

Mice genetically engineered to be susceptible to autism-like behaviors that were exposed to a common flame retardant were less fertile and their offspring were smaller, less sociable and demonstrated marked deficits in learning and long-term memory when compared with the offspring of normal unexposed mice, a study by researchers at UC Davis has found.

16 Feb 2012

Biochemists determine first crystal structure of an immunoproteasome

Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively kills cells that due to a viral infection present non-self peptides at their surface. In autoimmune diseases this mechanism is deregulated and the immune system also eliminates uninfected cells by mistake.

16 Feb 2012