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CytRx commences INNO-206 Phase 2 clinical trial for pancreatic cancer

CytRx Corporation, a biopharmaceutical company specializing in oncology, today announced the initiation of a Phase 2 clinical trial evaluating the preliminary efficacy and safety of INNO-206 in patients with advanced pancreatic ductual adenocarcinomas (PDA) who have progressed after receiving two prior therapies.

26 Apr 2012

AAA to gather for anatomy meeting in conjunction with Experimental Biology 2012

The American Association of Anatomists will gather this week for its annual meeting in conjunction with the Experimental Biology 2012 conference, which will draw more than 14,000 scientists from industry, government and academia. Below are some programming highlights for the anatomy meeting. All presentations will be made at the San Diego Convention Center.

26 Apr 2012

RANK inhibitor-chemotherapy combination may have important therapeutic effects against breast cancer

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have shown that overactivation of the RANK signalling pathway promotes the initiation, progression and metastasis of tumours in human breast epithelial cells by dedifferentiation of breast cells to stem cells. The results of this study have been advanced in the electronic edition of the journal Cancer Research.

25 Apr 2012

Expression of specific GPCRs appears to play a role in prognosis of CLL

Researchers at the University of California-San Diego School of Medicine have shown that G protein-coupled receptor expression may predict the prognosis of patients with chronic lymphocytic leukemia. Their findings may identify new ways to treat such patients.

25 Apr 2012

Robot-assisted surgery more common and successful in treating prostate cancer

Robot-assisted surgery is now both more common and far more successful than radical "open" surgery to treat prostate cancer in the United States, according to a new Henry Ford Hospital study published in the current issue of the medical journal European Urology.

24 Apr 2012

Cadmium exposure can cause progression of aggressive breast cancer

Studies by researchers at Dominican University of California show that breast cancer cells become increasingly aggressive the longer they are exposed to small concentrations of cadmium, a heavy metal commonly found in cosmetics, food, water and air particles.

24 Apr 2012

TopBP1 protein prevents early brain cells from DNA damage

St. Jude Children's Research Hospital scientists have rewritten the job description of the protein TopBP1 after demonstrating that it guards early brain cells from DNA damage. Such damage might foreshadow later problems, including cancer.

24 Apr 2012

Researchers identify molecular pathway that controls retention, release of the brain's stem cells

Researchers at Columbia University Medical Center (CUMC) have identified a molecular pathway that controls the retention and release of the brain's stem cells.

23 Apr 2012

Scientists discover tumor-targeting neural stem cells

Could engineered human stem cells hold the key to cancer survival? Scientists at the Institute of Bioengineering and Nanotechnology (IBN), the world's first bioengineering and nanotechnology research institute, have discovered that neural stem cells possess the innate ability to target tumor cells outside the central nervous system. This finding, which was demonstrated successfully on breast cancer cells, was recently published in leading peer reviewed journal, Stem Cells.

21 Apr 2012

Developments in mesothelioma treatment presented at 3rd European Lung Cancer Conference

New results presented at 3rd European Lung Cancer Conference in Geneva, Switzerland show important steps being made to improve the diagnosis and treatment of malignant pleural mesothelioma, an aggressive cancer of the outer lining of the lungs caused by asbestos exposure.

19 Apr 2012

Study finds lack of cervical screening in non-Caucasian, young and socioeconomically deprived women

New research published today in the Journal of Public Health has found that cervical screening participation is significantly lower in general practices that look after a high percentage of younger-aged women, non-Caucasian women and those living in areas of socioeconomic deprivation. The authors, Ji Young Bang, Ghasem Yadegarfar, Michael Soljak and Azeem Majeed, suggest that this disparity needs to be addressed by developing and implementing strategies to improve cervical screening attendance in these women.

19 Apr 2012

New techniques show promise in detecting early-stage lung cancer

New techniques for identifying lung cancer earlier -including a new type of chest screening, a nanotech 'nose' and a method to examine the cells of the cheek-- are showing substantial promise, according to presentations at the 3rd European Lung Cancer Conference (ELCC) in Geneva.

19 Apr 2012

Differentiated luminal-like breast cancer cells can generate larger tumors

New findings in breast cancer research by an international team of scientists contradict the prevailing belief that only basal-like cells with stem cell qualities can form invasive tumors. Research led by Ole William Petersen at the University of Copenhagen (CU) and Mina Bissell of the Lawrence Berkeley National Laboratory (Berkeley Lab) and has shown that luminal-like cells with no detectable stem cell qualities can generate larger tumors than their basal-like counterparts.

19 Apr 2012

Simple, cost-effective saliva test to detect oral cancer

A Michigan State University surgeon is teaming up with a Lansing-area dental benefits firm on a clinical trial to create a simple, cost-effective saliva test to detect oral cancer, a breakthrough that would drastically improve screening and result in fewer people dying of the world's sixth most common cancer.

18 Apr 2012

IMRT facilitates radiation dose escalation without compromising long-term morbidity for prostate cancer

In an analysis of three different types of radiation therapy used to treat localized prostate cancer, compared with conformal radiation therapy, intensity-modulated radiation therapy (IMRT) was associated with fewer diagnoses of gastrointestinal adverse effects, hip fractures, and receipt of additional cancer treatments but more erectile dysfunction, while proton therapy was associated with more gastrointestinal adverse effects than IMRT.

18 Apr 2012

Engineered particles tied to penetratin discover, deliver ligands for mitochondria, ribosomes

Scientists who developed a technology for identifying and targeting unique protein receptor ZIP Codes on the cellular surface have found a way to penetrate the outer membrane and deliver engineered particles - called iPhage - to organelles inside the cell.

18 Apr 2012

Hydrophilic carbon cluster HADES can selectively kill brain cancer cells

Nanomedicine researchers at the Methodist Neurological Institute and Rice University have developed a way to selectively kill brain cancer cells by using a tiny syringe to deliver a combination of chemotherapy drugs directly into the cells. These findings will be published in the April 24 issue of the American Chemical Society journal ACS Nano.

17 Apr 2012

CT guided transthoracic fine needle aspiration might diagnose pulmonary nodules

Screening for lung cancer with low dose CT scans has been shown to save lives. However, research shows that when CT scans reveal nodules in the lungs, it is not cancerous 96 percent of the time. As a result, scientists are looking for ways to more accurately make a diagnosis. One way is by using a CT guided transthoracic fine needle aspiration.

16 Apr 2012

Novian Health commences multicenter Novilase Interstitial Laser Therapy clinical trial for breast cancer

Novian Health, developer of Novilase Breast Therapy, announced the company has begun a multicenter clinical trial on the use of Novilase Interstitial Laser Therapy (ILT) for the destruction of malignant breast tumors.

12 Apr 2012

Scientists use two different methods to visualize rare CTCs, double positive cells in mBC

New research from The Ohio State University utilizes two different methods to visualize circulating tumor cells (CTCs) as well as other unusual circulating cells with both epithelial and hematopoietic characteristics in metastatic breast cancer.

12 Apr 2012

Malignant News and Research

CytRx commences INNO-206 Phase 2 clinical trial for pancreatic cancer

AAA to gather for anatomy meeting in conjunction with Experimental Biology 2012

RANK inhibitor-chemotherapy combination may have important therapeutic effects against breast cancer

Expression of specific GPCRs appears to play a role in prognosis of CLL

Robot-assisted surgery more common and successful in treating prostate cancer

Cadmium exposure can cause progression of aggressive breast cancer

TopBP1 protein prevents early brain cells from DNA damage

Researchers identify molecular pathway that controls retention, release of the brain's stem cells

Scientists discover tumor-targeting neural stem cells

Developments in mesothelioma treatment presented at 3rd European Lung Cancer Conference

Study finds lack of cervical screening in non-Caucasian, young and socioeconomically deprived women

New techniques show promise in detecting early-stage lung cancer

Differentiated luminal-like breast cancer cells can generate larger tumors

Simple, cost-effective saliva test to detect oral cancer

IMRT facilitates radiation dose escalation without compromising long-term morbidity for prostate cancer

Engineered particles tied to penetratin discover, deliver ligands for mitochondria, ribosomes

Hydrophilic carbon cluster HADES can selectively kill brain cancer cells

CT guided transthoracic fine needle aspiration might diagnose pulmonary nodules

Novian Health commences multicenter Novilase Interstitial Laser Therapy clinical trial for breast cancer

Scientists use two different methods to visualize rare CTCs, double positive cells in mBC

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