Mouse Model News and Research

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Chronic lack of sleep, irregular sleep-wake cycles may increase risk of Parkinson's disease

Chronic lack of sleep and irregular sleep-wake cycles may be risk factors of Parkinson's disease, new work by researchers at the Lewis Katz School of Medicine at Temple University suggests. In an animal model, the researchers show that disturbances in circadian rhythm that exist before Parkinson's onset dramatically worsen motor and learning deficits brought on by the disease.

5 Apr 2016

Oral Salmonella-based vaccine could prevent Type 1 diabetes

A combined vaccine therapy including live Salmonella is a safe and effective way to prevent diabetes in mice and may point to future human therapies, a new study finds. The results will be on Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.

4 Apr 2016

Study may help identify unborn children at higher risk for birth defects

Researchers at the University of Toronto have discovered a novel function performed by the breast cancer 1 protein (BRCA1), which regulates DNA repair. Well known for the role it plays in breast and ovarian cancer, this study revealed that the BRCA1 protein actually plays a much broader biological role, particularly in protecting the developing embryo from the damaging effects of reactive oxygen species (ROS).

1 Apr 2016

Study links voluntary exercise during pregnancy to more physically active children

Baylor College of Medicine researchers have discovered that female mice that voluntarily exercise during pregnancy have offspring that are more physically active as adults. The research appears in The FASEB Journal.

1 Apr 2016

Penn researchers discover molecular mechanism that underlies common cerebrovascular disease

Cerebral cavernous malformations (CCMs) are clusters of dilated, thin-walled blood vessels in the brain that can cause stroke and seizures, yet exactly how they form is somewhat of a mystery. Now, a team from the Perelman School of Medicine at the University of Pennsylvania has discovered the molecular mechanism that underlies this common cerebrovascular disease. They published their results this week online ahead of print in Nature.

31 Mar 2016

Scientists develop mouse model to gain new insights into genetic mechanisms underlying AML

A novel mouse model of a highly lethal form of acute myeloid leukemia (AML) offers a new tool for scientists working to better understand this disease and research new therapeutic targets.

31 Mar 2016

Understanding neuronal feedback could provide new insight into visual perception

Ever see something that isn't really there? Could your mind be playing tricks on you? The "tricks" might be your brain reacting to feedback between neurons in different parts of the visual system, according to a study published in the Journal of Neuroscience by Carnegie Mellon University Assistant Professor of Biological Sciences Sandra J. Kuhlman and colleagues.

31 Mar 2016

Scientists identify RingoA protein as key regulator of meiosis

Published today in Nature Communications, a study by scientists at the Institute for Research in Biomedicine headed by ICREA researcher Angel R. Nebreda has reported that the protein RingoA is a key regulator of meiosis--the cell division process that gives rise to ovules and sperm for sexual reproduction in mammals.

31 Mar 2016

Research describes first new mouse model for Zika infection in decades

Efforts to combat the rapid spread of Zika virus got a boost this week as researchers at the University of Texas Medical Branch, Galveston (UTMB) announced the first peer-reviewed publication of a mouse model for Zika infection reported in decades.

30 Mar 2016

Embryos with abnormalities in initial stages of pregnancy may grow into healthy babies

Abnormal cells in the early embryo are not necessarily a sign that a baby will be born with a birth defect such as Down's syndrome, suggests new research carried out in mice at the University of Cambridge. In a study published today in the journal Nature Communications, scientists show that abnormal cells are eliminated and replaced by healthy cells, repairing - and in many cases completely fixing - the embryo.

29 Mar 2016

Wnt secretion inhibitors may reduce renal fibrosis

Renal fibrosis or the scarring of kidneys, following an injury, reduces their function and can cause kidney disease to progressively worsen.

25 Mar 2016

Microneedle-embedded patch delivers cancer immunotherapy directly to melanoma

Biomedical engineering researchers at North Carolina State University and the University of North Carolina at Chapel Hill have developed a technique that uses a patch embedded with microneedles to deliver cancer immunotherapy treatment directly to the site of melanoma skin cancer. In animal studies, the technique more effectively targeted melanoma than other immunotherapy treatments.

25 Mar 2016

MALDI tissue imaging spots early renal lipid changes in acute kidney injury

University of Alabama at Birmingham researchers have made a microscopic snapshot of the early renal lipid changes in acute kidney injury, using the laser-scanning method called MALDI tissue imaging to localize the changes.

24 Mar 2016

SLU researchers discover compound that disrupts fibrotic process

Saint Louis University researchers have found that a type of compound that disrupts the process that causes fibrosis (scarring) in the lungs and liver also shows promise in preventing and treating fibrosis in yet another organ, the pancreas. The research was conducted in an animal model.

23 Mar 2016

Synchronized waves of calcium in the brain can reduce depressive symptoms

Researchers at the RIKEN Brain Science Institute in Japan have discovered that the benefits of stimulating the brain with direct current come from its effects on astrocytes -- not neurons -- in the mouse brain.

23 Mar 2016

Aging-associated changes begin earlier than expected in human brain

A new study published in Physiological Genomics suggests that the brain shows signs of aging earlier than old age. The study found that the microglia cells—the immune cells of the brain—in middle-aged mice already showed altered activity seen in microglia from older mice.

21 Mar 2016

Study: Cox2 inhibition improves outcomes in preeclampsia-like mouse model

Preeclampsia is characterized by elevated blood pressure in the second half of pregnancy and impaired blood flow to the placenta, which increases the risk of premature birth and pregnancy complications.

21 Mar 2016

USF receives $9 million NIH grant to study unique treatment for age-related hearing loss

Researchers in the University of South Florida's Global Center for Hearing and Speech Research, recognized as the world's top research center for age-related hearing loss, have received a five-year, $9 million grant from the National Institutes of Health to study two unique ways to treat age-related hearing loss (ARHL).

17 Mar 2016

Psoriasis patients experience widespread bone loss

Researchers from the Genes, Development and Disease Group, headed by Erwin Wagner at the Spanish National Cancer Research Centre have discovered that psoriasis patients experience a widespread bone loss as a result of the disease.

17 Mar 2016

Anti-anxiety drug reduces autistic features in Jacobsen syndrome mice

About half of children born with Jacobsen syndrome, a rare inherited disease, experience social and behavioral issues consistent with autism spectrum disorders. Researchers at University of California, San Diego School of Medicine and collaborators developed a mouse model of the disease that also exhibits autism-like social behaviors and used it to unravel the molecular mechanism that connects the genetic defects inherited in Jacobsen syndrome to effects on brain function.

16 Mar 2016

Mouse Model News and Research

Chronic lack of sleep, irregular sleep-wake cycles may increase risk of Parkinson's disease

Oral Salmonella-based vaccine could prevent Type 1 diabetes

Study may help identify unborn children at higher risk for birth defects

Study links voluntary exercise during pregnancy to more physically active children

Penn researchers discover molecular mechanism that underlies common cerebrovascular disease

Scientists develop mouse model to gain new insights into genetic mechanisms underlying AML

Understanding neuronal feedback could provide new insight into visual perception

Scientists identify RingoA protein as key regulator of meiosis

Research describes first new mouse model for Zika infection in decades

Embryos with abnormalities in initial stages of pregnancy may grow into healthy babies

Wnt secretion inhibitors may reduce renal fibrosis

Microneedle-embedded patch delivers cancer immunotherapy directly to melanoma

MALDI tissue imaging spots early renal lipid changes in acute kidney injury

SLU researchers discover compound that disrupts fibrotic process

Synchronized waves of calcium in the brain can reduce depressive symptoms

Aging-associated changes begin earlier than expected in human brain

Study: Cox2 inhibition improves outcomes in preeclampsia-like mouse model

USF receives $9 million NIH grant to study unique treatment for age-related hearing loss

Psoriasis patients experience widespread bone loss

Anti-anxiety drug reduces autistic features in Jacobsen syndrome mice

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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