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Researchers identify genetic variations linked with onset of Barrett's oesophagus

Genetic variations that are linked with the onset of Barrett's oesophagus (BE), a pre-cancerous condition of the lower end of the gullet, have been identified for the first time. The discovery of variations in regions on two chromosomes makes it possible to develop screening tests for people at high risk of developing the disease.

10 Sep 2012

Scientists characterize the lung squamous cell carcinoma genome

In the September 9, 2012 early online edition of Nature, scientists with The Cancer Genome Atlas (TCGA) report that they have characterized the lung squamous cell carcinoma genome.

10 Sep 2012

Insight into how tissue stiffness drives cancer

The stiffness of breast tissue is increasingly recognized as an important factor explaining the onset of breast cancer. Stiffening induces molecular changes that promote cancerous behavior in cells. Bioengineering studies have found that breast cancer cells grown on a 3-D gel have enhanced cell replication and decreased organization as rigidity increases.

10 Sep 2012

New strategy will have positive impact on people with brain disorders

New research offers a possible strategy for treating central nervous system diseases, such as brain and spinal cord injury, brain cancer, epilepsy, and neurological complications of HIV. The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

10 Sep 2012

UK public oppose cancer drugs fund but support new pricing system for branded medicines

The public oppose the cancer drugs fund but support the new pricing system for branded medicines, according to a new study.

10 Sep 2012

UH lecture to explore hormones in health and disease

While estrogen is essential for many of the body's normal processes in both men and women, it also plays a role in diseases such as breast, ovarian and prostate cancer. The impact of this hormone on such diseases will be addressed during a lecture Sept. 25 at the University of Houston (UH).

10 Sep 2012

Scientists report first comprehensive genetic analysis of lung squamous cell carcinoma

A nationwide consortium of scientists has reported the first comprehensive genetic analysis of squamous cell carcinoma of the lung, a common type of lung cancer responsible for about 400,000 deaths each year.

10 Sep 2012

FDA warns dietary supplement firms in Colorado and Texas

The U.S. Food and Drug Administration today issued warning letters to PruTect Rx, of Highlands Ranch, Colo., and Trinity Sports Group Inc., of Plano, Texas, for promoting products labeled as dietary supplements with claims to treat concussions and prevent or treat post-concussion syndrome and other neurological disorders.

7 Sep 2012

NPR blog examines 'test and treat' approach as HIV/AIDS prevention tactic

NPR's "Shots" blog examines the "test and treat" approach to HIV care and prevention, which "relies on the fact that taking HIV drugs dramatically reduces a person's risk of transmitting the virus to others," and, "[a]s more and more people are put on medication, the epidemic theoretically should fizzle out." The blog continues, "Test and treat sounds good on paper, but some doctors and policymakers have doubts about its feasibility on a large scale."

7 Sep 2012

Enrollment complete in DOUBle Phase 3 clinical trial of AzaSite Plus and DexaSite for blepharitis

InSite Vision Incorporated today announced that patient enrollment has been completed in the DOUBle Phase 3 clinical trial of AzaSite Plus (ISV-502) and DexaSite (ISV-305) for the treatment of blepharitis.

7 Sep 2012

Strategic roadmap to help cope with impending Alzheimer's disease public health crisis

This week, a strategic roadmap to help to the nation's health care system cope with the impending public health crisis caused Alzheimer's disease and related dementia will be published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

7 Sep 2012

Leukemia & Lymphoma Society awards SCOR program grant to Walter and Eliza Hall Institute team

Research into the natural process of cell death, its role in the development of blood cancers and harnessing cell death to improve cancer therapies has seen a Walter and Eliza Hall Institute research team from Melbourne, Australia, awarded a grant of more than $6 million by the US-based Leukemia & Lymphoma Society.

7 Sep 2012

Reuters examines challenges to implementing 'treatment as prevention,' other HIV prevention strategies in current economic climate

In an "Insight" feature article, Reuters examines how new information on the prevention benefits of HIV treatment and other strategies, such as male circumcision, "could finally break the back of the AIDS epidemic."

7 Sep 2012

Mammalian target of rapamycin inhibitors can prevent radiation-induced tissue damage

Radiation therapy is one of the most widely used cancer treatments, but it often damages normal tissue and can lead to debilitating conditions. A class of drugs known as mammalian target of rapamycin (mTOR) inhibitors can prevent radiation-induced tissue damage in mice by protecting normal stem cells that are crucial for tissue repair, according to a preclinical study published by Cell Press in the September issue of the journal Cell Stem Cell.

7 Sep 2012

Married patients with locally advanced lung cancer likely to survive longer after treatment

Married patients with locally advanced lung cancer are likely to survive longer after treatment than patients who are single, according to a study by researchers at the University of Maryland Marlene and Stewart Greenebaum Cancer Center in Baltimore.

7 Sep 2012

Washington Post examines India's efforts against TB amid fears of drug resistance

The Washington Post examines how the "discovery of an almost untreatable form of tuberculosis [TB] in India has set off alarm bells around the world and helped spur a dramatic expansion of government efforts to battle the killer lung disease."

7 Sep 2012

History of TB policy shows need for care, investment equity in developed, developing countries

In a 200th anniversary article for the New England Journal of Medicine, Salmaan Keshavjee of the Department of Global Health and Social Medicine at Harvard Medical School and Paul Farmer of Partners in Health "seek to elucidate the reasons for the anemic response to drug-resistant tuberculosis [TB] by examining the recent history of tuberculosis policy," they write.

7 Sep 2012

The Institute of Cancer Research, CRT and Astex to discover and develop novel drug candidates

Astex Pharmaceuticals, Inc, a pharmaceutical company dedicated to the discovery and development of novel small molecule therapeutics, Cancer Research Technology Limited (CRT) and The Institute of Cancer Research, London, have initiated a collaboration to discover and develop drug candidates targeting an undisclosed epigenetic target in a blood cancer with high unmet medical need.

7 Sep 2012

Hebrew University researcher develops anti-inflammatory and anti-allergic family of drugs

A synthetic, anti-inflammatory and anti-allergic family of drugs to combat a variety of illnesses while avoiding detrimental side effects has been developed by a Hebrew University of Jerusalem researcher.

7 Sep 2012

Study finds PARP1 and EZH2 as potential therapeutic targets for small cell lung cancer

Newly discovered molecular differences between small cell lung cancer and nonsmall cell lung cancer have revealed PARP1 and EZH2 as potential therapeutic targets for patients with small cell lung cancer, according to the results of a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

7 Sep 2012

Drugs News and Research

Researchers identify genetic variations linked with onset of Barrett's oesophagus

Scientists characterize the lung squamous cell carcinoma genome

Insight into how tissue stiffness drives cancer

New strategy will have positive impact on people with brain disorders

UK public oppose cancer drugs fund but support new pricing system for branded medicines

UH lecture to explore hormones in health and disease

Scientists report first comprehensive genetic analysis of lung squamous cell carcinoma

FDA warns dietary supplement firms in Colorado and Texas

NPR blog examines 'test and treat' approach as HIV/AIDS prevention tactic

Enrollment complete in DOUBle Phase 3 clinical trial of AzaSite Plus and DexaSite for blepharitis

Strategic roadmap to help cope with impending Alzheimer's disease public health crisis

Leukemia & Lymphoma Society awards SCOR program grant to Walter and Eliza Hall Institute team

Reuters examines challenges to implementing 'treatment as prevention,' other HIV prevention strategies in current economic climate

Mammalian target of rapamycin inhibitors can prevent radiation-induced tissue damage

Married patients with locally advanced lung cancer likely to survive longer after treatment

Washington Post examines India's efforts against TB amid fears of drug resistance

History of TB policy shows need for care, investment equity in developed, developing countries

The Institute of Cancer Research, CRT and Astex to discover and develop novel drug candidates

Hebrew University researcher develops anti-inflammatory and anti-allergic family of drugs

Study finds PARP1 and EZH2 as potential therapeutic targets for small cell lung cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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