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Bioengineers reveal how to recreate complex folded shapes from living tissue

Many of the complex folded shapes that form mammalian tissues can be recreated with very simple instructions, UC San Francisco bioengineers report December 28 in the journal Developmental Cell.

30 Dec 2017

Experts report new guidelines for clinical trial design in patients with brain metastases

Clinical trials of new anti-cancer therapies have often excluded patients whose disease has spread to the brain or central nervous system (CNS) or, if such patients were allowed on trial, trials have often failed to clearly capture information on the drug's effect in the brain.

30 Dec 2017

Blueberry extract can enhance effectiveness of cervical cancer treatment

According to the Centers for Disease Control and Prevention, approximately 12,000 women in the United States are diagnosed with cervical cancer each year.

29 Dec 2017

Gene therapy with CAR T-cells could create long-term immunity from HIV

Through gene therapy, researchers engineered blood-forming stem cells (hematopoietic stem/progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV-infected cells.

29 Dec 2017

Discovery of key protein’s structure may help improve drug design

Scientists at The Scripps Research Institute have peered deep into the heart of a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases.

29 Dec 2017

Researchers find way to prevent Ebola infection from spreading

A single enzyme. That is all the researchers behind a new study need to manipulate to prevent the feared Ebola virus from spreading. Because with the enzyme they also take away the virus' ability to copy itself and thus produce more virus particles and more infection.

29 Dec 2017

Selenium protects specialized neurons from cell death during postnatal development

Exactly 200 years ago, the Swedish scientist Jöns Jacob Berzelius discovered the trace element selenium, which he named after the goddess of the moon, Selene.

29 Dec 2017

Genes in Space-3 team identifies microbes in real time aboard the space station

Being able to identify microbes in real time aboard the International Space Station, without having to send them back to Earth for identification first, would be revolutionary for the world of microbiology and space exploration.

29 Dec 2017

Proteasome inhibitor treatment can lead to cardiovascular problems in multiple myeloma patients

The proteasome inhibitor carfilzomib has taken on an increasing role in the treatment of multiple myeloma, but new research from the Abramson Cancer Center of the University of Pennsylvania shows the therapy comes with the risk of cardiovascular problems in a higher than expected percentage of patients.

28 Dec 2017

Researchers use wrist-worn gadget to capture detailed information on human sleep cycles

To measure a person's sleep, researchers have always relied on costly and time-consuming approaches that could only be used in a sleep lab.

28 Dec 2017

UCLA study reveals positive effects of estrogen treatment in people with MS

A study by UCLA researchers reveals the cellular basis for how the hormone estrogen protects against damage to the central nervous system in people with multiple sclerosis (MS).

28 Dec 2017

Researchers reveal how tumor cells disrupt circadian rhythm to survive

Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, Hollings Cancer Center researchers at the Medical University of South Carolina find.

28 Dec 2017

$Study uncovers genomic targets in refractory neuroblastoma$

Study uncovers genomic targets in refractory neuroblastoma

Neuroblastoma (NB) is the most common solid tumor found in children. It starts in some very early forms of nerve cells found in the embryo or fetus.

28 Dec 2017

TUM scientists discover new substance to fight against tuberculosis

In search of new strategies against life-threatening tuberculosis infections, a team from the Technical University of Munich, as well as Harvard University and Texas A&M University in the USA have found a new ally.

28 Dec 2017

Research provides new understanding of how cancer cells move during metastasis

A University of Hawai'i Cancer Center researcher has identified how some cancer cells are made to move during metastasis. The research provides a better understanding of how cancer spreads and may create new opportunities for cancer drug development.

28 Dec 2017

Sickle cell patients, families and doctors face a ‘fight for everything’

The day before his 30th birthday, Marqus Valentine was in a panic. "I was so scared for midnight to come rolling around because subconsciously I was like, 'This is it. Tomorrow’s my last day on Earth,'" he said.

27 Dec 2017

Study highlights pernicious effect of obesity on blood-making stem cells

New research published in the Journal of Experimental Medicine highlights the pernicious effect of obesity on the long-term health of blood-making stem cells (hematopoietic stem cells).

27 Dec 2017

New approach to sticking bio-ink droplets together enables 3D printing of complex tissues

Printed replacement human body parts might seem like science fiction, but this technology is rapidly becoming a reality with the potential to greatly contribute to regenerative medicine. Before any real applications, "bioprinting" still faces many technical challenges.

27 Dec 2017

Reduced activity of transcription factor plays key role in triggering pulmonary fibrosis

To date, the molecular basis of pulmonary fibrosis has been poorly understood. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of the disease.

26 Dec 2017

Nanobiotix receives FDA approval for first immuno-oncology trial

NANOBIOTIX, a late clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced the U.S. Food and Drug Administration has approved its Investigational New Drug Application for NBTXR3, a first-in-class nanoparticle designed for direct injection into cancerous tumors, activated by stereotactic ablative radiotherapy (SABR) and administered in combination with an anti-PD1 antibody (nivolumab or pembrolizumab).

26 Dec 2017