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Anti-cancer drugs may also fight antibiotic resistance

Drugs used to overcome cancer may also combat antibiotic resistance, finds a new study led by Gerry Wright, scientific director of the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University.

23 Dec 2011

LincRNAs play key roles during embryonic brain development

Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during embryonic brain development in zebrafish. They also show that the human versions of the lincRNAs can substitute for the zebrafish versions, which implies that the functions of these non-coding RNAs have been retained in humans as well as fish.

23 Dec 2011

Researchers reveal what cells respond to anesthesia in C. elegans

Physicians use inhalation anesthetics in a way that is incredibly safe for patients, but very little is known about the intricacies of how these drugs actually work in children and adults. Now, researchers have uncovered what cells respond to anesthesia in an organism known as the C. elegans, according to a new study from the Seattle Children's Research Institute. C. elegans is a transparent roundworm used often in research.

23 Dec 2011

Researchers present results from 31 major studies of blood-related cancers at ASH 2011 meeting

Researchers from the John Theurer Cancer Center at Hackensack University Medical Center, one of the nation's top 50 best hospitals for cancer, presented results from 31 major studies of blood-related cancers - leukemia, lymphoma and multiple myeloma -- during the American Society of Hematology (ASH) Annual Meeting, December 10-13, 2011 in San Diego.

23 Dec 2011

Scientists discover mechanism by which TNFα stimulates tumor formation

An inflammation-promoting protein triggers deactivation of a tumor-suppressor that usually blocks cancer formation via the NOTCH signaling pathway, a team of researchers led by scientists at The University of Texas MD Anderson Cancer Center reports today in Molecular Cell.

23 Dec 2011

Gladstone, Bristol-Myers Squibb to identify and validate novel targets in Alzheimer's

Bristol-Myers Squibb Company and the Gladstone Institutes today announced the formation of a discovery-based research collaboration to identify and validate novel targets in Alzheimer's disease.

23 Dec 2011

Researchers identify previously unknown gene fusion event in lung cancer

Smoking is a well-known risk factor for lung cancer, but nearly 25% of all lung cancer patients have never smoked. In a study published online today in Genome Research, researchers have identified a previously unknown gene fusion event that could explain a significant proportion of lung cancer cases in never-smokers, and might serve as a target for new therapies.

23 Dec 2011

New way to awaken paternal Ube3a allele linked with Angelman syndrome

Results of a new study from the University of North Carolina at Chapel Hill may help pave the way to a treatment for a neurogenetic disorder often misdiagnosed as cerebral palsy or autism.

22 Dec 2011

Lean beef can contribute to heart-healthy diet

Lean beef can contribute to a heart-healthy diet in the same way lean white meats can, according to nutritional scientists.

22 Dec 2011

AVEO initiates enrollment in tivozanib and mFOLFOX6 Phase 2 combination trial for CRC

AVEO Pharmaceuticals, Inc. today announced the initiation of patient enrollment in an open-label, multicenter, randomized Phase 2 clinical trial, called BATON-CRC, evaluating tivozanib in combination with modified FOLFOX6 (mFOLFOX6) compared to bevacizumab in combination with mFOLFOX6 as first-line therapy in patients with advanced metastatic colorectal cancer.

22 Dec 2011

Low-gluten beers can cause symptoms in patients with celiac disease

Beer tested in a new study, including some brands labeled "low-gluten," contains levels of hordein, the form of gluten present in barley, that could cause symptoms in patients with celiac disease (CD), the autoimmune condition treated with a life-long gluten-free diet, scientists are reporting.

22 Dec 2011

New silk-based microneedle system for controlled-release drug delivery

Bioengineers at Tufts University School of Engineering have developed a new silk-based microneedle system able to deliver precise amounts of drugs over time and without need for refrigeration. The tiny needles can be fabricated under normal temperature and pressure and from water, so they can be loaded with sensitive biochemical compounds and maintain their activity prior to use. They are also biodegradable and biocompatible.

22 Dec 2011

Gottlieb specialist, NWCR offer top weight-loss tips

Losing weight and saving money are the top New Year's resolutions expected to challenge Americans this year, experts say.

22 Dec 2011

Researchers map every apparent physical interaction of HIV virus with human cells

In perhaps the most comprehensive survey of the inner workings of HIV, an international team of scientists led by researchers at the University of California, San Francisco has mapped every apparent physical interaction the virus makes with components of the human cells it infects—work that may reveal new ways to design future HIV/AIDS drugs.

22 Dec 2011

Scientists discover N-cadherin as promising therapeutic target for pancreatic cancer

Often, and without much warning, pancreatic cancer cells slip through the endothelial cells, head into the blood and out to other parts of the body to metastasize, making it one of the deadliest and hardest to treat cancers today.

22 Dec 2011

Researchers discover how c-MYC facilitates tumor growth

Cancer cells are essentially immortal. The acquisition of an unlimited capacity to divide - the process of immortalization - is a central event in the genesis of tumors. Normally, cells are subject to stringent mechanisms which control their proliferation. Together these ensure that pre-malignant cells are induced to enter a senescent, non-dividing state or to undergo apoptosis, i.e. commit suicide.

22 Dec 2011

Researchers evaluate Clade C HIV envelope protein in Phase I trial

In the first clinical trial of an injectable vaccine containing trimeric HIV envelope protein (gp140) relevant to the predominant strain of HIV in Africa, researchers from four UK academic centers (St George's University London, Imperial College, Hull York Medical School (HYMS; University of York) and the Medical Research Council Clinical Trial Unit) and from the Infectious Disease Research Institute (IDRI) have come together to evaluate whether the vaccine is safe for use in human volunteers.

22 Dec 2011

Researchers discover how normal cells in tumors can drive cancer growth

•A new study published in the journal Nature Cell Biology has discovered how normal cells in tumors can fuel tumor growth.

22 Dec 2011

Agilent acquires BioSystem Development business

Agilent Technologies Inc. today announced it has completed the acquisition of the BioSystem Development business. BioSystem Development is a privately held company that develops and manufactures the AssayMAP Microchromatography platform to meet the analytical needs of the life sciences industry.

22 Dec 2011

Malaria vaccine shows early success

An experimental vaccine for malaria has been developed by British scientists. It has shown early potential to neutralize many, perhaps all, strains of the deadliest malaria parasite.

21 Dec 2011