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Mechanism provides beneficial characteristics of energy-burning brown fat to white fat

Columbia University Medical Center (CUMC) researchers have identified a mechanism that can give energy-storing white fat some of the beneficial characteristics of energy-burning brown fat. The findings, based on studies of mice and of human fat tissue, could lead to new strategies for treating obesity and type 2 diabetes.

3 Aug 2012

Sta Op Tegen Kanker International Translational Cancer Research Grant recipients announced

Stand Up To Cancer (SU2C) and the Dutch Cancer Society (KWF Kankerbestrijding), along with the American Association for Cancer Research (AACR), SU2C's Scientific Partner, announce the recipients of the Sta Op Tegen Kanker International Translational Cancer Research Grant.

3 Aug 2012

First Edition: August 3, 2012

Today's headlines include reports on a Capitol Hill hearing during which House GOP lawmakers grilled the director of the Internal Revenue Service on his agency's health care subsidy ruling.

3 Aug 2012

Allergy alerts in patient records help improve clinical practice

Allergy alerts in patient records have the potential to significantly improve clinical practice, say Spanish researchers.

3 Aug 2012

Researchers, politicians gather in London for Global Health Policy Summit

Medical researchers, politicians, and policymakers gathered at a Global Health Policy Summit in London Wednesday "to champion innovative solutions to the world's major health problems," Imperial College London reports in an article, which notes the summit, "the first event of its kind, is the result of a partnership between Imperial College London and the Qatar Foundation for education, science and community development" and "will tackle maternal health, primary care, non-infectious diseases and aging societies".

3 Aug 2012

Viewpoints: Orszag on CAP cost-control proposals; High-tech and health costs

The Center for American Progress proposals thus wisely recognize that there is no single strategy to continue the recent progress in slowing the growth in health-care costs. In contrast, the Republican budget plan put forward by Representative Paul Ryan of Wisconsin seems based on a belief that all that's needed is to shift risks: from Medicare to beneficiaries through a premium-support program, and from the federal government to state governments by turning Medicaid into block grants.

3 Aug 2012

Foods high in sugar and fat could have addictive properties

Overweight and obese individuals can achieve a decade's worth of important health benefits by losing just 20 pounds, even if they regain the weight later that decade, according to research presented at the American Psychological Association's 120th Annual Convention. With a focus on psychology's role in overcoming the national obesity epidemic, the session also examined research that indicates foods high in sugar and fat could have addictive properties.

3 Aug 2012

Change in drug policy needed to reverse HIV/AIDS epidemic in Eastern Europe, Central Asia

Noting the United Nations last week announced the appointment of Dr. Michel Kazatchkine, the former head of the Global Fund to Fight AIDS, Tuberculosis and Malaria, as the U.N. Secretary-General's new special envoy for HIV/AIDS in Eastern Europe and Central Asia," Kasia Malinowska-Sempruch, director of the Open Society Foundations' global drug policy program, writes in this Huffington Post opinion piece.

3 Aug 2012

Combination of sitagliptin and lansoprazole offers clinical benefits for T1D patients

Sanford Project researchers have reached a critical milestone in a clinical trial testing a combination of two medications to determine if the drugs can help patients with type 1 diabetes (T1D) keep their blood glucose levels under control with less or no insulin. The full number of patients needed to complete this first trial, termed Restore Pancreatic Insulin Response in type 1 diabetes (REPAIR-T1D), has been reached.

2 Aug 2012

Train-Match-Fit-Streamline uses 11 factors to quickly pair likely drugs and diseases

With the cost of putting a single new drug on the pharmacy shelves topping a staggering $1 billion, scientists are reporting development of a way to determine if an already-approved drug might be used to treat a different disease. The technique for repurposing existing medicines could cut drug development costs and make new medicine available to patients faster, they report in ACS' Journal of Medicinal Chemistry.

2 Aug 2012

Investigational drug shows promise against most severe form of congenital hyperinsulinism

A pilot study in adolescents and adults has found that an investigational drug shows promise as the first potential medical treatment for children with the severest type of congenital hyperinsulinism, a rare but potentially devastating disease in which gene mutations cause insulin levels to become dangerously high.

2 Aug 2012

Combination hormonal therapy improves survival in advanced breast cancer

A study co-authored by a Loyola researcher and published in the New England Journal of Medicine is offering new hope to women with advanced breast cancer.

2 Aug 2012

Curcumin emerges as prime candidate for less expensive AD treatment

The spice compound that gives curry dishes their yellow color and pungent flavor is emerging as a prime candidate for a less expensive treatment for Alzheimer's disease (AD), according to an article in the current edition of Chemical & Engineering News. C&EN is the weekly newsmagazine of the American Chemical Society, the world's largest scientific society.

2 Aug 2012

Combination of anastrozole and fulvestrant extends survival in women with metastatic breast cancer

Results of a SWOG clinical trial published August 2 in the New England Journal of Medicine show the combination of anastrozole and fulvestrant extended the median survival time of women with hormone receptor-positive metastatic breast cancer by more than six months compared to women treated with a standard therapy of anastrozole alone (47.7 months vs 41.3 months).

2 Aug 2012

Possible molecular link between circadian rhythm disturbances and increased inflammatory response

Scientists have known for some time that throwing off the body's circadian rhythm can negatively affect body chemistry. In fact, workers whose sleep-wake cycles are disrupted by night shifts are more susceptible to chronic inflammatory diseases such as diabetes, obesity and cancer.

2 Aug 2012

Scientists discover critical molecular switch that regulates autophagy

The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural degeneration and cancer.

2 Aug 2012

New FDA risk management plan aims to reduce opioid abuse in the U.S.

A new risk management plan from the U.S. Food and Drug Administration to help clinicians properly prescribe drugs with addiction potential aims to help reduce the growing epidemic of opioid abuse in the United States.

2 Aug 2012

MLK3 protein critical driver of breast cancer cell migration and invasion

By identifying a key protein that tells certain breast cancer cells when and how to move, researchers at Michigan State University hope to better understand the process by which breast cancer spreads, or metastasizes.

2 Aug 2012

Flightless molecule may help control spread of cancer from one tissue to another

Thanks to the "flightless" molecule, the spread of cancer from one tissue to another may one day be grounded. In a new report published in the August 2012 print issue of The FASEB Journal, laboratory experiments show that "flightless" (named after its effects on fruit flies) increases the "stickiness" that causes cells, including cancer cells, to attach to underlying tissue, which in turn, slows their movement throughout the body.

1 Aug 2012

Scientists decode stability blueprint of rhomboid enzyme

Johns Hopkins scientists have decoded for the first time the "stability blueprint" of an enzyme that resides in a cell's membrane, mapping which parts of the enzyme are important for its shape and function.

1 Aug 2012

Drugs News and Research

Mechanism provides beneficial characteristics of energy-burning brown fat to white fat

Sta Op Tegen Kanker International Translational Cancer Research Grant recipients announced

First Edition: August 3, 2012

Allergy alerts in patient records help improve clinical practice

Researchers, politicians gather in London for Global Health Policy Summit

Viewpoints: Orszag on CAP cost-control proposals; High-tech and health costs

Foods high in sugar and fat could have addictive properties

Change in drug policy needed to reverse HIV/AIDS epidemic in Eastern Europe, Central Asia

Combination of sitagliptin and lansoprazole offers clinical benefits for T1D patients

Train-Match-Fit-Streamline uses 11 factors to quickly pair likely drugs and diseases

Investigational drug shows promise against most severe form of congenital hyperinsulinism

Combination hormonal therapy improves survival in advanced breast cancer

Curcumin emerges as prime candidate for less expensive AD treatment

Combination of anastrozole and fulvestrant extends survival in women with metastatic breast cancer

Possible molecular link between circadian rhythm disturbances and increased inflammatory response

Scientists discover critical molecular switch that regulates autophagy

New FDA risk management plan aims to reduce opioid abuse in the U.S.

MLK3 protein critical driver of breast cancer cell migration and invasion

Flightless molecule may help control spread of cancer from one tissue to another

Scientists decode stability blueprint of rhomboid enzyme

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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