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Embryonic signalling pathways suggest a new therapeutic approach to recover from heart attack

Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, are the first to prove that this signalling pathway targets heart muscle cells and thus reveal its crucial role in heart development and repair

10 Dec 2009

Roche launches new automated clinical laboratory system for HPV and CT/NG tests

Roche Molecular Systems, Inc. (SIX: RO, ROG; OTCQX: RHHBY) announced today the launch of a new clinical laboratory system designed to increase laboratory testing efficiency and to accommodate current and long-term molecular diagnostic needs.

10 Dec 2009

Genetic variations in Sonic Hedgehog pathway associated with response to standard immunotherapy

Genetic variations in the Sonic Hedgehog pathway increase the likelihood of recurrence, reduce survival time and limit response to therapy for people with non-muscle invasive bladder cancer, scientists from The University of Texas M. D. Anderson Cancer Center reported today at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference.

10 Dec 2009

Cardiologists receive K23 research grant from NIH

Brian H. Annex, M.D., chief of the Division of Cardiovascular Medicine at the University of Virginia Health System, says he feels like the coach of a championship team. "Going three for three is truly extraordinary," he says with a mixture of pride and awe in his voice.

10 Dec 2009

Robarts researcher identifies protein which regulates cell suicide

When cells experience DNA damage, they'll try to repair it. But if that fails, the damaged cells are supposed to self-destruct, a process called apoptosis. A cancer researcher at Robarts Research Institute at The University of Western Ontario has identified a protein that regulates apoptosis, a new discovery which has implications for both the diagnosis and treatment of cancer. Caroline Schild-Poulter's findings are now published online in the journal Molecular Cancer Research.

10 Dec 2009

Scientists identify potential drug development target for epilepsy seizures

A team of scientists from The University of Alabama used worms to reel in information that they hope will lead to a greater understanding of cellular mechanisms that may be exploited to treat epilepsy.

10 Dec 2009

Alternative, fast and safe process for producing large quantities of effective flu vaccines

A shortage of flu vaccines may soon become a problem of the past. Researcher Manon Cox has developed an alternative process for producing large quantities of safe and effective vaccines at twice to four times the usual speed. The process is based on using cells in bioreactors instead of fertilised chicken's eggs, which have a limited availability.

9 Dec 2009

MLL team finds 454 Sequencing technology promising for leukemia genetic characterization

This week at the 51st American Society for Hematology Annual Meeting, a team of researchers from the MLL Munich Leukemia Laboratory presented results from a series of groundbreaking studies which explore alternative, high-throughput 454 Sequencing methods for distinguishing and characterizing the many forms of leukemia and myeloproliferative disorders.

9 Dec 2009

Protalix Biotherapeutics completes NDA submission for taliglucerase alfa

Protalix Biotherapeutics, Inc. today announced the completion of its New Drug Application (NDA) submission with the U.S. Food and Drug Administration (FDA) for taliglucerase alfa, a plant-cell expressed form of glucocerebrosidase (GCD) for the potential treatment of Gaucher’s disease.

9 Dec 2009

CIDR utilizes Isilon scale-out NAS for genotyping and statistical genetics services

Isilon Systems today announced that the Center for Inherited Disease Research (CIDR) at Johns Hopkins University is using Isilon scale-out NAS to power its leading-edge genotyping and statistical genetics services, which generate up to three terabytes of new data per day.

9 Dec 2009

TECHGENE project: CLC bio selected as software partner

Today the EU project, TECHGENE, that focuses on developing Next Generation Sequencing (NGS) diagnostic tools for genetic disorders, announced that CLC bio has been selected as the software partner for this project.

9 Dec 2009

Scientists discuss sex lives of fruit flies

Females can be too attractive to the opposite sex -- too attractive for their own good -- say biologists at UC Santa Barbara. They found that, among fruit flies, too much male attention directed toward attractive females leads to smaller families and, ultimately, to a reduced rate of population-wide adaptive evolution.

9 Dec 2009

Human blood stem cells can be engineered to kill HIV and other chronic viral diseases

Researchers from the UCLA AIDS Institute and colleagues have for the first time demonstrated that human blood stem cells can be engineered into cells that can target and kill HIV-infected cells - a process that potentially could be used against a range of chronic viral diseases.

9 Dec 2009

CSC's stem cell-derived motor neuron product for SMA receives FDA orphan drug designation

California Stem Cell, Inc. (CSC) and Families of Spinal Muscular Atrophy (FSMA) announced today that the FDA has granted orphan drug designation to MOTORGRAFT™, a stem cell-derived motor neuron product, for the treatment of Spinal Muscular Atrophy (SMA).

9 Dec 2009

New findings may help restore vision in patients with corneal injury

Winston Whei-Yang Kao, PhD, professor of ophthalmology, along with other researchers in UC's ophthalmology department found that transplanting human umbilical mesenchymal stem cells into mouse models that lack the protein lumican restored the transparency of cloudy and thin corneas.

9 Dec 2009

GPEC receives unrestricted grant of $250,000 to study new treatments for breast cancer

Located at Vancouver General Hospital and a partner of the BC Cancer Agency, the Genetic Pathology Evaluation Centre, led by three prominent pathologists, is a recognized world leader in cancer research in the area of biomarker technology. Today, with an additional unrestricted grant of $250,000 from sanofi-aventis, GPEC is ready to make even more scientific breakthroughs.

9 Dec 2009

Smokers taking the Respiragene test try to quit smoking, reveals study

Smokers who see their own personal risk of developing lung cancer after genetic-based testing show stronger intention and take more action on quitting smoking, according to clinical trial results presented to an American Association of Cancer Research conference.

9 Dec 2009

Researchers study incidence of heterosis for different characteristics

When two gene pools combine, you might expect the characteristics of the offspring to end up somewhere in the middle between those of its parents. But children often have characteristics that are better or worse than that middle value, sometimes even better than both parents.

9 Dec 2009

Mouse model may help identify unknown mutations that make lung cancer cells resistant to therapy

Lung cancer is the leading cause of cancer mortality worldwide and lung adenocarcinoma is the most common type. Many cases of lung adenocarcinoma are attributed to a mutation in a gene for the epidermal growth factor receptor (EGFR).

9 Dec 2009

Kennedy Krieger Institute opens new center for individuals with muscle disorders

Kennedy Krieger Institute announced today the opening of the new Center for Genetic Muscle Disorders that will improve and expand services to individuals with muscle disorders such as muscular dystrophy and congenital myopathy in the Baltimore/Washington region and across the nation. The Center provides expert clinical care to children and adults with these disorders, and offers leading research programs both in the clinical and laboratory setting.

9 Dec 2009

Genetic News and Research

Embryonic signalling pathways suggest a new therapeutic approach to recover from heart attack

Roche launches new automated clinical laboratory system for HPV and CT/NG tests

Genetic variations in Sonic Hedgehog pathway associated with response to standard immunotherapy

Cardiologists receive K23 research grant from NIH

Robarts researcher identifies protein which regulates cell suicide

Scientists identify potential drug development target for epilepsy seizures

Alternative, fast and safe process for producing large quantities of effective flu vaccines

MLL team finds 454 Sequencing technology promising for leukemia genetic characterization

Protalix Biotherapeutics completes NDA submission for taliglucerase alfa

CIDR utilizes Isilon scale-out NAS for genotyping and statistical genetics services

TECHGENE project: CLC bio selected as software partner

Scientists discuss sex lives of fruit flies

Human blood stem cells can be engineered to kill HIV and other chronic viral diseases

CSC's stem cell-derived motor neuron product for SMA receives FDA orphan drug designation

New findings may help restore vision in patients with corneal injury

GPEC receives unrestricted grant of $250,000 to study new treatments for breast cancer

Smokers taking the Respiragene test try to quit smoking, reveals study

Researchers study incidence of heterosis for different characteristics

Mouse model may help identify unknown mutations that make lung cancer cells resistant to therapy

Kennedy Krieger Institute opens new center for individuals with muscle disorders

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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