Hormones News and Research

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Combination of two antibodies prevents growth and spread of triple-negative breast tumors

Cancer drugs of the new, molecular generation destroy malignant breast tumors in a targeted manner: They block characteristic molecules on tumor cells - receptors for the hormones estrogen or progesterone, or a co-receptor, called HER2, that binds to many growth factors. But about one in every six breast tumors has none of these receptors. Such cancers, called triple-negative, are particularly aggressive and notoriously difficult to treat.

10 Feb 2013

Researchers design guideline for physicians and patients on Androgen Insensitivity Syndrome

University of Granada researchers have designed a guideline for physicians and patients on the Androgen Insensitivity Syndrome (AIS), a rare disease that makes the subject develop reverse sex, which occurs when a subject looks like a woman but has male genes.

7 Feb 2013

Investigators use genome analysis to eliminate lifetime drug prescription in two children

Using genome-wide analysis, investigators at the Sainte-Justine University Hospital Research Center and the University of Montreal have potentially eliminated a lifetime drug prescription that two children with a previously unknown type of adrenal insufficiency had been receiving for 14 years.

4 Feb 2013

Study shows how female steroid hormones can make changes to the breast genetic material

Melbourne scientists have discovered how female steroid hormones can make dramatic changes to the genetic material in breast cells, changes that could potentially lead to breast cancer.

2 Feb 2013

Retired Jackson Laboratory scientist wins two major international science awards

Douglas Coleman, Ph.D., a retired Jackson Laboratory scientist whose work established the first clues to a genetic component in obesity, has won two major international science awards: the Frontiers of Knowledge Award in Biomedicine from the BBVA Foundation, based in Bilbao, Spain, and the King Faisal International Prize in Medicine from the Saudi Arabian King Faisal Foundation.

31 Jan 2013

Timing of meals predicts weight-loss effectiveness

Most weight-loss plans center around a balance between caloric intake and energy expenditure. However, new research has shed light on a new factor that is necessary to shed pounds: timing. Researchers from Brigham and Women's Hospital (BWH), in collaboration with the University of Murcia and Tufts University, have found that it's not simply what you eat, but also when you eat, that may help with weight-loss regulation.

30 Jan 2013

ADRB receptors play a direct role in Src activation by PKA-mediated mechanism

Scientists at The University of Texas MD Anderson Cancer Center have discovered the signaling pathway whereby a master regulator of cancer cell proteins - known as Src - leads to ovarian cancer progression when exposed to stress hormones. The researchers report in the current issue of Nature Communications that beta blocker drugs mitigate this effect and reduce cancer deaths by an average of 17 percent.

30 Jan 2013

Prediagnostic androgen level not linked to prostate cancer outcome

Low prediagnostic levels of circulating sex hormones are not associated with more aggressive disease in patients with prostate cancer, say US researchers.

28 Jan 2013

FDA approves Takeda’s NESINA, OSENI and KAZANO for treatment of type 2 diabetes

Takeda Pharmaceutical Company Limited and its wholly-owned subsidiary, Takeda Pharmaceuticals U.S.A., Inc. today announced that the United States (U.S.) Food and Drug Administration (FDA) has approved NESINA (alogliptin) and the fixed-dose combination (FDC) therapies OSENI (alogliptin and pioglitazone) and KAZANO (alogliptin and metformin HCl) for the treatment of type 2 diabetes in adults as adjuncts to diet and exercise.

28 Jan 2013

Study shows how GATA3 protein acts downstream biochemically to prevent breast cancer metastasis

The spread of breast cancer to distant organs within the body, an event that often leads to death, appears in many cases to involve the loss of a key protein, according to UC San Francisco researchers, whose new discoveries point to possible targets for therapy.

28 Jan 2013

African-American women who reported childhood abuse had greater risk of uterine fibroids

According to a new study from the Slone Epidemiology Center (SEC) at Boston University, African-American women who reported sexual or physical abuse before age 11 had a greater risk of uterine fibroids in adulthood compared with women who had no such abuse history.

25 Jan 2013

Mice exposed to BPA exhibit spontaneous activity, have leaner body mass

Female mice exposed to Bisphenol A through their mother's diet during gestation and lactation were found to be hyperactive, exhibit spontaneous activity and had leaner body mass than those not exposed to the chemical, researchers at the University of Michigan School of Public Health have discovered.

25 Jan 2013

Tall, thin women face increased risk of infection with nontuberculous mycobacteria

Tall, thin women face a greater risk of infection with nontuberculous mycobacteria (NTM), cousins of the organism that causes tuberculosis, according to researchers at National Jewish Health. Women with NTM infections also showed a weakened immune response associated with their fat cells, in a paper published in the Jan. 15, 2013, issue of The American Journal of Respiratory and Critical Care.

23 Jan 2013

Very low levels of BPS can disrupt natural estrogen hormone actions

A few years ago, manufacturers of water bottles, food containers, and baby products had a big problem. A key ingredient of the plastics they used to make their merchandise, an organic compound called bisphenol A, had been linked by scientists to diabetes, asthma and cancer and altered prostate and neurological development.

23 Jan 2013

Bladder cancer risk associated with childbearing factors

The risk for bladder cancer in women may decline with increased parity and older age at first birth, researchers report.

21 Jan 2013

Albumin may prove a predictor for pneumonia outcomes

Researchers say that assessing serum albumin levels within 24 hours of admission could be a good prognostic marker of community-acquired pneumonia.

21 Jan 2013

New review examines role of nutrition in sarcopenia

Sarcopenia, or the gradual loss of muscle mass, is a common consequence of ageing, and poses a significant risk factor for disability in older adults. As muscle strength plays an important role in the tendency to fall, sarcopenia leads to an increased risk of fractures and other injuries.

19 Jan 2013

Intestinal bacteria can produce biochemicals and hormones that stop development of diabetes

All humans have enormous numbers of bacteria and other micro-organisms (10 to 14) in the lower intestine. In fact our bodies contain about ten times more bacteria than our own cells and these tiny passengers are extremely important for our health. They help us digest our food and provide us with energy and vitamins.

19 Jan 2013

Stress in adolescence can cause severe mental illness in young adulthood

Working with mice, Johns Hopkins researchers have established a link between elevated levels of a stress hormone in adolescence — a critical time for brain development — and genetic changes that, in young adulthood, cause severe mental illness in those predisposed to it.

18 Jan 2013

Early life exposure to gut microbes protects against autoimmune disease

Early life exposure to normal bacteria of the GI tract (gut microbes) protects against autoimmune disease in mice, according to research published on-line in the January 17 edition of Science. The study may also have uncovered reasons why females are at greater risk of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and lupus compared to males.

18 Jan 2013

Hormones News and Research

Combination of two antibodies prevents growth and spread of triple-negative breast tumors

Researchers design guideline for physicians and patients on Androgen Insensitivity Syndrome

Investigators use genome analysis to eliminate lifetime drug prescription in two children

Study shows how female steroid hormones can make changes to the breast genetic material

Retired Jackson Laboratory scientist wins two major international science awards

Timing of meals predicts weight-loss effectiveness

ADRB receptors play a direct role in Src activation by PKA-mediated mechanism

Prediagnostic androgen level not linked to prostate cancer outcome

FDA approves Takeda’s NESINA, OSENI and KAZANO for treatment of type 2 diabetes

Study shows how GATA3 protein acts downstream biochemically to prevent breast cancer metastasis

African-American women who reported childhood abuse had greater risk of uterine fibroids

Mice exposed to BPA exhibit spontaneous activity, have leaner body mass

Tall, thin women face increased risk of infection with nontuberculous mycobacteria

Very low levels of BPS can disrupt natural estrogen hormone actions

Bladder cancer risk associated with childbearing factors

Albumin may prove a predictor for pneumonia outcomes

New review examines role of nutrition in sarcopenia

Intestinal bacteria can produce biochemicals and hormones that stop development of diabetes

Stress in adolescence can cause severe mental illness in young adulthood

Early life exposure to gut microbes protects against autoimmune disease

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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