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Researchers link specific gene mutations with four recognized subtypes of medulloblastoma

Researchers at Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) and several collaborating institutions have linked mutations in specific genes to each of the four recognized subtypes of medulloblastoma, the most common malignant brain tumor of children. The discovery, reported July in the journal Nature, provides doctors with potential biomarkers for guiding and individualizing treatment and reveals prospective therapeutic opportunities for countering this devastating malignancy.

23 Jul 2012

International Congress on Natural Products Research to be held in New York City

The urgent need to evaluate nature's repository of chemicals in plants, microbes, and marine organisms for their potential value in health care will be a major theme of a five-day scientific conference in New York that is expected to draw some 1,200 natural products researchers from around the world.

21 Jul 2012

WHO identifies key actions countries can take to prevent HIV infections among people who inject drugs

WHO has identified four key actions countries can take to prevent viral hepatitis B and C among people who inject drugs. Of the estimated 16 million people who inject drugs worldwide, it is estimated that 10 million are infected with hepatitis C. An additional 1.2 million are infected with hepatitis B.

21 Jul 2012

IAS releases 'road map' to find HIV cure ahead of AIDS 2012 Conference

The International AIDS Society (IAS) on Thursday in Washington, D.C., "released what they call a road map for research toward a cure for HIV -- a strategy for global teams of scientists to explore a number of intriguing leads that just might, years from now, pan out," the Associated Press reports (Neergaard, 7/20).

21 Jul 2012

Kyprolis for multiple myeloma receives FDA approval under accelerated approval program

The U.S. Food and Drug Administration today approved Kyprolis (carfilzomib) to treat patients with multiple myeloma who have received at least two prior therapies, including treatment with Velcade (bortezomib) and an immunomodulatory therapy. A form of blood cancer that arises from plasma cells, multiple myeloma usually grows in bone marrow, the soft, spongy tissue found inside most bones.

21 Jul 2012

New CHAIT initiative on development of novel immunological therapeutic interventions

The CHAIT initiative is a public-private partnership focusing on the development of novel immunological therapeutic interventions to achieve a 'functional HIV cure' with the ultimate goal of HIV eradication.

21 Jul 2012

FDA's approval of Kyprolis offers hope to myeloma patients, says IMF

The International Myeloma Foundation (IMF) - the oldest and largest foundation dedicated to improving the life and care of myeloma patients - says today's Food and Drug Administration approval of Onyx's Kyprolis (carfilzomib) offers hope to myeloma patients who have run out of options when available therapies have stopped working.

21 Jul 2012

When checks and balances in the pharmaceutical marketplace fall short

The Washington Post explores how a trio of very expensive anemia drugs became "superstars" in the marketplace. Also, The Wall Street Journal tracks the process by which certain fake cancer drugs found their way into the United States.

21 Jul 2012

Training EMS to interpret ECGs can expedite treatment for severe heart attacks

A new program that trains emergency medical service technicians (EMS) to read electrocardiograms so that they can evaluate patients with chest pain, and expedite treatment for the severe heart condition known as ST-segment elevation myocardial infarction (STEMI), a serious form of heart attack, has excellent results and should become the standard of care, according to two studies published in the current issue of the Canadian Journal of Cardiology.

21 Jul 2012

2-D models may often give researchers misleading results

Imagine millions of cancer cells organized in thousands of small divots. Hit these cells with drugs and when some cells die, you have a candidate for a cancer drug. But a review published this week in the journal Expert Opinion on Drug Discovery argues that these 2D models in fact offer very little information about a potential drug's effects in the body and may often give researchers misleading results.

21 Jul 2012

In Florida, Obama attacks Romney on Medicare plan

Drawing on traditional Democratic campaign themes, President Barack Obama criticized GOP plans to transform Medicare into a "voucher program" and to repeal the 2010 health law.

21 Jul 2012

Cipla, DNDi to develop ARV combination therapy for children with HIV/AIDS

On the eve of the XIX International AIDS Conference in Washington, DC, the Drugs for Neglected Diseases initiative (DNDi), a not-for-profit research and development (R&D) organization, announces a new collaboration with Indian drug manufacturer Cipla to develop and produce an improved first-line antiretroviral (ARV) combination therapy specifically adapted to meet the treatment needs of infants and toddlers living with HIV/AIDS.

21 Jul 2012

Viewpoints: Creating an HIV-free generation; Postal Service's struggle over retiree health benefits

HIV forces us to deal with so much: sex, drugs, poverty, racism, homelessness, homophobia, sexism, illness and death. While our nation's response has been imperfect, we have gotten a lot right. And we are now at a pivotal moment where science has led us to imagine the possibility of an HIV-free generation.

21 Jul 2012

Novartis receives FDA approval for Afinitor to treat HER2-negative breast cancer

The U.S. Food and Drug Administration today approved Afinitor (everolimus) for use in combination with Aromasin (exemestane) to treat certain postmenopausal women with advanced hormone-receptor positive, HER2-negative breast cancer.

21 Jul 2012

Phosphate binders may cause unexpected harm to blood vessels in patients with CKD

Drugs commonly prescribed to patients with chronic kidney disease (CKD) may not be as strongly effective as once thought, and may cause unexpected harm to blood vessels, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

20 Jul 2012

Unsuccessful fertility treatment reduces young-onset breast cancer risk

Women who are treated unsuccessfully with fertility drugs have a significantly reduced risk for developing young-onset breast cancer, compared with nonusers of such drugs, show the results of a sister-matched case-control study.

20 Jul 2012

Cannabis use linked to cognitive performance in bipolar patients

Results from a US study suggest that bipolar I disorder patients with a history of cannabis use have better neurocognitive function than those who have not used cannabis.

20 Jul 2012

Natural compound can virtually eradicate HIV in infected culture cells

A new study by scientists on the Florida campus of The Scripps Research Institute shows, in cell culture, a natural compound can virtually eliminate human immunodeficiency virus (HIV) in infected cells. The compound defines a novel class of HIV anti-viral drugs endowed with the capacity to repress viral replication in acutely and chronically infected cells.

20 Jul 2012

T2Hemostasis provides reliable and rapid results when compared to conventional systems

T2 Biosystems, a company developing direct detection products enabling superior diagnostics, today announced the presentation of new data on hemostasis monitoring at the American Association for Clinical Chemistry Annual Meeting, July 15-19, 2012, in Los Angeles, CA.

20 Jul 2012

UNAIDS releases report highlighting gains, gaps in global HIV/AIDS response

Ahead of the XIX International AIDS Conference next week, UNAIDS on Wednesday launched a new report, titled "Together we will end AIDS", "that shows that a record eight million people are now receiving antiretroviral therapy [ARVs], and that domestic funding for HIV has exceeded global investments," the U.N. News Centre reports.

20 Jul 2012

Drugs News and Research

Researchers link specific gene mutations with four recognized subtypes of medulloblastoma

International Congress on Natural Products Research to be held in New York City

WHO identifies key actions countries can take to prevent HIV infections among people who inject drugs

IAS releases 'road map' to find HIV cure ahead of AIDS 2012 Conference

Kyprolis for multiple myeloma receives FDA approval under accelerated approval program

New CHAIT initiative on development of novel immunological therapeutic interventions

FDA's approval of Kyprolis offers hope to myeloma patients, says IMF

When checks and balances in the pharmaceutical marketplace fall short

Training EMS to interpret ECGs can expedite treatment for severe heart attacks

2-D models may often give researchers misleading results

In Florida, Obama attacks Romney on Medicare plan

Cipla, DNDi to develop ARV combination therapy for children with HIV/AIDS

Viewpoints: Creating an HIV-free generation; Postal Service's struggle over retiree health benefits

Novartis receives FDA approval for Afinitor to treat HER2-negative breast cancer

Phosphate binders may cause unexpected harm to blood vessels in patients with CKD

Unsuccessful fertility treatment reduces young-onset breast cancer risk

Cannabis use linked to cognitive performance in bipolar patients

Natural compound can virtually eradicate HIV in infected culture cells

T2Hemostasis provides reliable and rapid results when compared to conventional systems

UNAIDS releases report highlighting gains, gaps in global HIV/AIDS response

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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