Heart News and Research

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TAVI procedure effective in patients unsuitable for surgical valve replacement: Study

One-year data from the PARTNER clinical trial, published today in the New England Journal of Medicine, demonstrate that transcatheter aortic-valve implantation, compared with standard therapy, resulted in significantly lower rates of death among patients who cannot undergo surgery for aortic stenosis. The results will be presented tomorrow as a Late Breaking Trial at the 22nd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium.

23 Sep 2010

New study signals hope for treatment of rare neurodegenerative disease

A new study led by St. Jude Children's Research Hospital scientists signals hope for treatment of a neurodegenerative disease and a new model for understanding the mechanism at work in other more common neurodegenerative disorders.

23 Sep 2010

MAQUET enrolls first patient in OPTION trial

MAQUET Cardiovascular LLC, a leading provider of cardiovascular technologies, today announced enrollment of the first patient in the OPTION (Optimal Improvement of Vein Graft Patency Long Term by the Implementation Of Novel Endoscopic Harvesting Techniques) trial which is designed to assess patient outcomes using a standardized, best practices approach in endoscopic vessel harvesting (EVH) for coronary artery bypass graft surgery (CABG) compared with open vein harvesting methods.

23 Sep 2010

Implantation of new bioprosthetic-tissue valve in patients with severe aortic stenosis saves lives

Implantation of a new bioprosthetic-tissue valve into the hearts of patients who have severe aortic stenosis and are too sick or too old for open-heart surgery has been found to both save lives and improve the quality of those lives, according to a new multicenter study, to be published online at 2 p.m. Pacific time today in the New England Journal of Medicine.

23 Sep 2010

Cardiovascular Innovation Institute awarded NIH grant to develop implantable pump for single ventricle heart disease

Researchers in the Cardiovascular Innovation Institute, a partnership between the University of Louisville and Jewish Hospital, in collaboration with researchers at Indiana University and Purdue University, have received a $2,027,059 grant from the National Institutes of Health to further develop an implantable pump that could dramatically improve the lives of patients with single ventricle heart disease.

23 Sep 2010

U.S. joins whistleblower suit against Pfizer for drug marketing

The Wall Street Journal: "The Justice Department is trying to take the lead in a lawsuit accusing Pfizer Inc.'s Wyeth unit of improperly promoting an organ-transplant drug for unauthorized uses and paying illegal kickbacks to doctors. The lawsuit was filed by two former Wyeth sales representatives who were responsible for promoting Rapamune, an immunosuppressant used to prevent the body's rejection of transplanted kidneys.

23 Sep 2010

AstraZeneca to use THEW database for cardiac safety evaluation

AstraZeneca purchased a one-year membership to gain access to an international repository of data designed to aid industry and academic researchers developing new technologies to improve cardiac safety.

23 Sep 2010

FDA approves Gilenya capsules for reducing MS relapses

The U.S. Food and Drug Administration has approved Gilenya capsules (fingolimod) to reduce relapses and delay disability progression in patients with relapsing forms of multiple sclerosis (MS).

22 Sep 2010

Vascular Disease Foundation honors UCSD professor with President's Award for Vision

The Vascular Disease Foundation has awarded Michael Criqui, MD, MPH, professor and chief of the Division of Preventive Medicine in the Department of Family and Preventive Medicine at the University of California, San Diego, one of its highest honors, the President's Award for Vision. The award was presented at the VDF's annual meeting in Alexandria, Virginia on September 20.

22 Sep 2010

Study finds certain MRI sequences as accurate methods of assessing stent stenosis

Researchers have found that magnetic resonance imaging (MRI) may be sufficient for the routine surveillance of some great vessel (primary blood vessels [e.g., aorta and vena cavae]) stents that are commonly used to treat congenital heart defects (a defect in the structure of the heart and great vessels that is present at birth) in children and young adults, according to a study in the October issue of the American Journal of Roentgenology (www.ajronline.org). MRI is a noninvasive medical test that helps physicians diagnose and treat medical conditions.

22 Sep 2010

Researchers investigate performance levels of resident and staff physicians

Research on the quality of US resident physician performance levels has often been limited by lack of a comparison group or strict focus on specific diseases and geographical areas. In order to gain insight on differences in quality of care provided by resident physicians versus staff physicians, Boston Medical Center and Palo Alto Medical Foundation researchers investigated performance of physicians in 33,900 hospital-based outpatient visits throughout the US.

22 Sep 2010

Paper calls for revision of STEMI guidelines around oxygen therapy

The European Society of Cardiology welcomes a paper published today in the Journal of the American College of Cardiology highlighting concerns over the use of oxygen therapy during MI in patients with normal oxygen levels. The publication adds to calls for revision of the STEMI guidelines around oxygen therapy and for a prospective, large scale randomised trials, issues that were both first raised in a Cochrane Review published in June.

22 Sep 2010

Study finds no benefit from self-management counseling in patients with heart failure

Patients with mild to moderate heart failure who received educational materials and self-management counseling in an attempt to improve adherence to medical advice did not have a reduced rate of death or hospitalization compared to patients who received educational materials alone, according to a study in the September 22/29 issue of JAMA.

22 Sep 2010

Newborn Coalition praises SACHDNC's Critical Congenital Heart Disease universal screening recommendation

In a historic vote on September 17, 2010, the Secretary's Advisory Committee for Heritable Disorders in Newborns and Children (SACHDNC) unanimously agreed to recommend the addition of screening for Critical Cyanotic Congenital Heart Disease to the core panel for universal screening of all newborns in the United States.

22 Sep 2010

Protein zyxin necessary for maintenance and repair of cell's cytoskeleton

Researchers at Huntsman Cancer Institute (HCI) at the University of Utah have discovered that a protein, zyxin, is necessary for the maintenance and repair of the cell's cytoskeleton, or internal framework, which serves as the muscle and bone of the cell. The research has implications for cancer, as well as other diseases, since alterations in the cytoskeleton are often associated with disease. The research was published in the Sep. 14, 2010, issue of the journal Developmental Cell.

22 Sep 2010

U.S. community health centers receive $500,000 grant to increase access to quality healthcare

The GE Foundation - the philanthropic organization of GE - announced today the award of $500,000 in total to two Baltimore-based community health centers in an effort to help increase access to quality healthcare across the United States. As part of the GE Developing HealthTM program, these grants will support Chase Brexton Health Services and People's Community Health Centers, Inc. in providing increased access to healthcare in their respective communities.

22 Sep 2010

JHS conference focuses on future research directions to eliminate health disparities

The tenth anniversary of the Jackson Heart Study (JHS) will be observed on Sept. 23-24 in Jackson, Mississippi. The JHS is the largest study in history to investigate genetic factors that affect high blood pressure, heart and lung disease, stroke, diabetes, and other important diseases in African-Americans.

22 Sep 2010

Zyxin protein is critical to maintain and repair internal framework

22 Sep 2010

ARRA's legacies may solve challenges related to health, energy and environment

The presidents of six leading research universities and two higher-education associations joined Vice President Joe Biden and White House science advisor Dr. John Holdren this morning to discuss the scientific research and related activities that have been made possible by the American Recovery and Reinvestment Act (ARRA).

22 Sep 2010

Physical or psychological stress before cancer treatment may sabotage therapy

Patients who experience physical or psychological stress - including rigorous exercise - one or two days before a cancer treatment might be unknowingly sabotaging their therapy, new research suggests.

22 Sep 2010

Heart News and Research

TAVI procedure effective in patients unsuitable for surgical valve replacement: Study

New study signals hope for treatment of rare neurodegenerative disease

MAQUET enrolls first patient in OPTION trial

Implantation of new bioprosthetic-tissue valve in patients with severe aortic stenosis saves lives

Cardiovascular Innovation Institute awarded NIH grant to develop implantable pump for single ventricle heart disease

U.S. joins whistleblower suit against Pfizer for drug marketing

AstraZeneca to use THEW database for cardiac safety evaluation

FDA approves Gilenya capsules for reducing MS relapses

Vascular Disease Foundation honors UCSD professor with President's Award for Vision

Study finds certain MRI sequences as accurate methods of assessing stent stenosis

Researchers investigate performance levels of resident and staff physicians

Paper calls for revision of STEMI guidelines around oxygen therapy

Study finds no benefit from self-management counseling in patients with heart failure

Newborn Coalition praises SACHDNC's Critical Congenital Heart Disease universal screening recommendation

Protein zyxin necessary for maintenance and repair of cell's cytoskeleton

U.S. community health centers receive $500,000 grant to increase access to quality healthcare

JHS conference focuses on future research directions to eliminate health disparities

Zyxin protein is critical to maintain and repair internal framework

ARRA's legacies may solve challenges related to health, energy and environment

Physical or psychological stress before cancer treatment may sabotage therapy

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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