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HIV markets in rich, poor countries are two distinct markets

HIV drugs have not only "transformed a fatal disease into a chronic one," but "[t]hey have also made HIV a big business," this Economist editorial states.

2 Jun 2012

Inhibiting IRE1α-XBP1 pathway impacts survival of myeloma cells

Results published in Blood, the official journal of the American Society of Hematology, confirm that inhibition of the IRE1α-XBP1 pathway impacts the survival of myeloma cells, suggesting a promising therapeutic option in multiple myeloma.

2 Jun 2012

Latest results from Youth Smoking Survey

According to the latest results of the Youth Smoking Survey, only three per cent of Canadian students in grades 6-12 said they smoked daily in 2010-2011, down from 4% in 2008-2009.

2 Jun 2012

Scientists discover previously unrecognized signaling network disrupted in lung cancer

A team of researchers led by Dr. Goutham Narla at Case Western Reserve University School of Medicine in collaboration with scientists at Mount Sinai School of Medicine in New York, have discovered a previously unrecognized signaling network disrupted in lung cancer that can be turned back on by a novel combination of two previously approved FDA drugs.

2 Jun 2012

Painkillers may reduce skin cancer risk

Commonly used painkillers called nonsteroidal anti-inflammatory drugs, such as aspirin and ibuprofen, may reduce the risk for skin cancer, study results suggest.

1 Jun 2012

Glucocorticoid steroids in intelligent medicine specifically hits relevant cells

Scientists at Aarhus University, Denmark in collaboration with the biotech company Cytoguide now publish a key to use glucocorticoid steroids in a kind of intelligent medicine that specifically hits the relevant cells. Data are based on rodent studies but if this principle is translated to humans it may greatly improve todays hazardous treatment with this type of potent steroids.

1 Jun 2012

Affymetrix, Leica Microsystems enter worldwide collaboration on RNA ISH analysis

Affymetrix, Inc. and Leica Microsystems are pleased to announce a world-wide collaboration that automates Affymetrix' QuantiGene ViewRNA ISH Tissue Assay on the Leica BOND RX staining platform for research applications.

1 Jun 2012

Distinctive protein pathways in certain leukemia patients

Scientists at Rice University and the University of Texas MD Anderson Cancer Center have successfully profiled protein pathways found to be distinctive to leukemia patients with particular variants of the disease.

1 Jun 2012

Formation of blood vessels in tumors attacked from two angles

As soon as they have grown to pinhead size, tumors rely on the formation of new blood vessels - a process which is scientifically called angiogenesis. Interfering with this process (antiangiogenesis) is considered to be a promising approach in cancer medicine. However, those drugs that are already available for preventing the sprouting of new blood capillaries have failed to fulfill the high expectations placed on them.

1 Jun 2012

Smoking during pregnancy affects weight of the newborns

Smoking during pregnancy has widely documented health repercussions both for mother and baby. A study at the University of Zaragoza on 1216 newly born babies confirms that those born to mothers who smoke weigh and measure less.

1 Jun 2012

Molecular structure of APP protein could lead to new therapeutics for AD

The molecular structure of a protein involved in Alzheimer's disease - and the surprising discovery that it binds cholesterol - could lead to new therapeutics for the disease, Vanderbilt University investigators report in the June 1 issue of the journal Science.

1 Jun 2012

Increased risk of bladder cancer linked to diabetes drug

Pioglitazone - a drug used to treat type 2 diabetes - is associated with an increased risk of bladder cancer, finds a study published on bmj.com today.

1 Jun 2012

Feds announce effort to slash inappropriate use of antipsychotic drugs in nursing homes

An estimated 40 percent of nursing home residents with dementia receive the drugs, which are approved to treat schizophrenia and bipolar disorder.

1 Jun 2012

Scientists discover genetic basis for CLOVES syndrome

Using advanced technologies for rapidly sequencing and analyzing DNA from clinical and pathologic samples, a multidisciplinary research team consisting of geneticists, pathologists and surgeons at Boston Children's Hospital has identified the genetic basis for CLOVES syndrome, a rare congenital malformation and overgrowth disorder.

1 Jun 2012

Personalized medicine and the Human Genome Project

It’s nearly a decade since the completion of the Human Genome Project, (1) which aimed to sequence the complete human genome.

1 Jun 2012

LILRB2 receptor plays an important role in keeping stem cells from differentiating

An immune-system receptor plays an unexpected but crucially important role in keeping stem cells from differentiating and in helping blood cancer cells grow, researchers at UT Southwestern Medical Center report today in the journal Nature.

1 Jun 2012

Scientists discover SL9266 'switch' in the Hepatitis C virus

Scientists have discovered a 'switch' in the Hepatitis C virus which could be used as a target for new kinds of drug treatment.

1 Jun 2012

Scientists succeed in solving first structure of a Wnt protein

The 20 proteins in the Wnt family are some of the most important proteins in controlling how an organism develops and grows, but for 30 years scientists have not known what these vital proteins actually look like. The proteins have eluded standard visualization techniques, in large part because they do not dissolve well in the water-based liquids normally used for biochemical studies.

1 Jun 2012

Functional disability impacts educational attainment in children with JIA

As children with juvenile idiopathic arthritis (JIA) grow into adulthood, disability due to disease may adversely affect their ability to achieve educational success. Findings published in Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR), suggest that functional disability impacts educational attainment, which is key to successful employment in adulthood.

1 Jun 2012

Kindstar, Insight Genetics collaborate to improve cancer care in China

Molecular diagnostics company Insight Genetics and Kindstar Globalgene Technology, Inc., China's leading diagnostics company, today announced that the companies are partnering to enhance cancer care in the People's Republic of China and surrounding regions.

1 Jun 2012