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Repression of endothelial TLR3 is a potential mechanism of SARS-CoV-2 infection-associated lung vascular remodeling

Researchers investigated whether endothelial TLR3 insufficiency contributes to lung vascular remodeling induced by SARS-CoV-2.

30 Jan 2023

Does a second monovalent SARS-CoV-2 mRNA booster increase neutralizing activity to Omicron variants in nursing home residents and healthcare workers?

Researchers investigated whether the second booster dose of monovalent COVID-19 mRNA vaccines increases antibody titers and neutralization potential against the SARS-CoV-2 Omicron VOC among NH residents and HCWs.

30 Jan 2023

Study suggests robust lung mucosal immunity against SARS-CoV-2 can be better achieved through hybrid immunity, as opposed to peripheral vaccination alone

Researchers characterized immunological responses by pulmonary mucosal tissues post-COVID-19 vaccination and/or SARS-CoV-2 infection, to assess the impact of hybrid immune protection on the durability of mucosal immunological responses.

30 Jan 2023

Scientists Develop a Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer

Dual-action cell therapy engineered to eliminate established tumors and train the immune system to eradicate primary tumor and prevent cancer’s recurrence.

30 Jan 2023

Children's tonsils are major sites of prolonged SARS-CoV-2 infection

A recent study evaluates the presence of SARS-CoV-2 in children’s tonsils during the COVID-19 pandemic.

29 Jan 2023

Voles can form enduring attachments with mates and provide parental care without oxytocin receptors

The vital role of oxytocin - the "love hormone" - for social attachments is being called into question. More than forty years of pharmacological and behavioral research has pointed to oxytocin receptor signaling as an essential pathway for the development of social behaviors in prairie voles, humans, and other species, but a genetic study publishing in the journal Neuron on January 27 shows that voles can form enduring attachments with mates and provide parental care without oxytocin receptor signaling.

29 Jan 2023

Biology underlying pair bonding and parenting may not be dictated by oxytocin receptors, study shows

Turning a decades-old dogma on its head, new research from scientists at UC San Francisco and Stanford Medicine shows that the receptor for oxytocin, a hormone considered essential to forming social bonds, may not play the critical role that scientists have assigned to it for the past 30 years.

27 Jan 2023

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

27 Jan 2023

Exploring an artificial neural network-based approach for detecting potentially infectious coronaviruses

Researchers used a machine-learning (ML)-based model to identify non-human CoVs (coronaviruses) that might cause human infections.

27 Jan 2023

UK oncologists and cardiologists collaborate to prevent chemo-induced cardiomyopathy in cancer patients

Ever since she was 12 years old, Barbie Johnson has been a Kentucky girl at heart. Raised in the bluegrass, Barbie has worked at UK HealthCare for 18 years, first in gynecologic oncology and now in surgery scheduling.

26 Jan 2023

Researchers discover the impact of microRNA on inflammation in lupus

A group of researchers from the Graduate School of Medicine at Nagoya University in Japan have discovered the impact of microRNA (miRNA) on inflammation in lupus in mice.

26 Jan 2023

New therapy-relevant marker may help identify ER+ breast cancer patients who may benefit from immunotherapies

A multi-institutional team led by scientists from the Medical College of Wisconsin Cancer Center has discovered PD-L2 as a therapy-relevant marker to identify patients with estrogen receptor-positive breast cancer who may benefit from new immunotherapies.

26 Jan 2023

New interactive tool helps to calculate risk of developing advanced breast cancer

Breast cancer is now the leading cause of global cancer incidence among women but determining who will develop breast cancer is still a challenge for the medical community.

25 Jan 2023

Study shows cutaneous touch neuronal cells to be critical for sexual receptiveness

Researchers studied the social relevance of G protein-coupled receptor (GPCR) Mrgprb4-lineage touch neurons in sexual touch and receptivity.

25 Jan 2023

Ospemifene and systemic hormone therapy improve vulvovaginal atrophy symptoms, study suggests

As women age, they are more susceptible to vaginal dryness and pain during intercourse because of vulvovaginal atrophy (VVA).

25 Jan 2023

Sex-specific patterns of cytokine activation in the hippocampus post-immunological challenge

Researchers evaluated sex-based differences among cytokine and chemokine networks in the hippocampus after systemic immunological challenge.

25 Jan 2023

Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model

A recent PNAS journal study has sought to address the above-stated drawback and developed a new strategy that involves a self-assembling scaffold of proliferating cell nuclear antigen (PCNA). This technique can develop nanoparticles containing evenly incorporated heterotypic antigens.

24 Jan 2023

Study reveals sex differences in response to drugs targeting tauopathies

Microglia are cells that are central to both brain health as well as disease progression in many neurological conditions.

24 Jan 2023

Researchers uncover new mechanism that plays key role in the progression of alcohol-related liver disease

Alcohol-related liver disease is among the most common causes of morbidity and mortality worldwide. Due to an incomplete understanding of the factors contributing to disease development, liver transplantation is still the only available cure.

24 Jan 2023

Researchers identify a key host-cell player in COVID-19 infections

Researchers at University of California San Diego and UC Riverside have further elucidated the molecular pathway used by the SARS-CoV-2 virus to infect human lung cells, identifying a key host-cell player that may prove a new and enduring therapeutic target for treating COVID-19.

24 Jan 2023

Receptor News and Research

Repression of endothelial TLR3 is a potential mechanism of SARS-CoV-2 infection-associated lung vascular remodeling

Does a second monovalent SARS-CoV-2 mRNA booster increase neutralizing activity to Omicron variants in nursing home residents and healthcare workers?

Study suggests robust lung mucosal immunity against SARS-CoV-2 can be better achieved through hybrid immunity, as opposed to peripheral vaccination alone

Scientists Develop a Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer

Children's tonsils are major sites of prolonged SARS-CoV-2 infection

Voles can form enduring attachments with mates and provide parental care without oxytocin receptors

Biology underlying pair bonding and parenting may not be dictated by oxytocin receptors, study shows

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

Exploring an artificial neural network-based approach for detecting potentially infectious coronaviruses

UK oncologists and cardiologists collaborate to prevent chemo-induced cardiomyopathy in cancer patients

Researchers discover the impact of microRNA on inflammation in lupus

New therapy-relevant marker may help identify ER+ breast cancer patients who may benefit from immunotherapies

New interactive tool helps to calculate risk of developing advanced breast cancer

Study shows cutaneous touch neuronal cells to be critical for sexual receptiveness

Ospemifene and systemic hormone therapy improve vulvovaginal atrophy symptoms, study suggests

Sex-specific patterns of cytokine activation in the hippocampus post-immunological challenge

Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model

Study reveals sex differences in response to drugs targeting tauopathies

Researchers uncover new mechanism that plays key role in the progression of alcohol-related liver disease

Researchers identify a key host-cell player in COVID-19 infections

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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