Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Galapagos NV receives milestone payment to initiate Phase I clinical trial of GLPG0555 drug

Galapagos NV (Euronext: GLPG) announced today that it has initiated clinical Phase I development of the first small molecule candidate from its arthritis alliance with GlaxoSmithKline (GSK).

8 Dec 2009

Long-chain omega-3 fatty acids can prevent colorectal cancer

Long-chain omega-3 fatty acids, primarily found in fish and seafood, may have a role in colorectal cancer prevention, according to results presented at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference, held Dec. 6-9, 2009, in Houston.

8 Dec 2009

Galapagos NV issues new shares

Galapagos NV (Euronext: GLPG) announced today a capital increase of EUR 902,564 and the issue of 225,641 new shares as a result of the exercise of warrants by Galapagos warrant holders, including CEO Onno van de Stolpe.

7 Dec 2009

TGFb growth factor controls spread of cancer cells

The spread, or metastasis, of individual breast cancer cells from the main tumor into the blood circulation to the lungs and other body tissues and organs is under the control of a growth factor abbreviated TGFb, according to a study with laboratory mice that will be presented at the American Society for Cell Biology (ASCB) 49th Annual Meeting, Dec. 5-9, 2009 in San Diego.

7 Dec 2009

'Twist' gene plays a key role in the development of breast cancer

Working with mice, scientists at Johns Hopkins publishing in the December issue of Neoplasia have shown that a protein made by a gene called "Twist" may be the proverbial red flag that can accurately distinguish stem cells that drive aggressive, metastatic breast cancer from other breast cancer cells.

5 Dec 2009

TGen scientists win $1,000 prize for best scientific paper presented at BIBM09

A team of scientists at the Translational Genomics Research Institute (TGen) won a $1,000 prize for best scientific paper presented at BIBM09, a premier bioinformatics and biomedicine conference.

3 Dec 2009

Galapagos' multiple milestone achievement triggers cash payment of EUR 10.2 million

Galapagos NV announced today achievement of multiple milestones under its alliance agreement in rheumatoid arthritis. The milestones trigger a cash payment of EUR 10.2 million to Galapagos.

3 Dec 2009

Coding guidelines for Agendia's MammaPrint test established by Palmetto GBA

Agendia, a world leader in molecular cancer diagnostics, announced today that Palmetto GBA, California's Part B Medicare administrator, has established coding guidelines for the company's MammaPrint test.

2 Dec 2009

Human Melanoma Research Team pursuing identification of anti-tumor prognostic markers and drugs

The constant increase in the rate of cutaneous melanoma over recent years and its resistance to anti-tumour pharmaceutical drugs has meant that the study of cutaneous melanoma is one of the greatest scientific challenges in the field of cancer. The Human Melanoma research team at the University of the Basque Country (UPV/EHU) is focusing on this study.

2 Dec 2009

CT imaging combined with Avastin may predict overall survival in metastatic colorectal cancer

Using routine computed tomography (CT) imaging to analyze form and structural changes to colorectal liver metastasis after bevacizumab and chemotherapy may predict overall survival, according to research from The University of Texas M. D. Anderson Cancer Center.

2 Dec 2009

TGF--1 suppresses the growth of cancer cells, find researchers

UT Southwestern Medical Center researchers have found that a naturally occurring protein -- transforming growth factor beta1 (TGF--1) -- which normally suppresses the growth of cancer cells, causes a rebound effect after a prolonged exposure.

2 Dec 2009

DFG approves establishment of new CRCs; research topics range from modern prostheses to political reforms to marine bacteria

The DFG has approved the establishment of 17 new Collaborative Research Centres as of 1 January 2010. This decision was made recently by the relevant Grants Committee in Bonn.

1 Dec 2009

Researchers devise a way to deliver right therapy directly to tumors using aptamers

Finding and treating a tumor without disturbing normal tissue presents challenges - sometimes the most effective therapies can be invasive and harsh.

1 Dec 2009

OSEO awards fund for Galapagos NV's antibody therapeutics program

Galapagos NV announces that its antibody therapeutics program with MorphoSys and SARM program have been awarded funding by the French governmental organization OSEO.

26 Nov 2009

Wnt signaling pathway plays a role in diabetic retinopathy

A group led by Dr. Jian-xing Ma at The University of Oklahoma Health Sciences Center, Oklahoma City, OK has demonstrated that the Wnt signaling pathway plays a role in diabetic retinopathy.

26 Nov 2009

Wnt and EGFR signaling pathways interact to promote tumor cell invasion and metastasis

Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers from The University of Texas M. D. Anderson Cancer Center report in the Nov. 25 issue of Molecular Cell.

26 Nov 2009

HPA-specific shRNA holds potential as a novel therapeutic strategy for gastric cancer

Previous studies have indicated that the heparanase (HPA) is correlated with histopathological parameters and poor prognosis of gastric cancers. Although their efficiencies in inhibiting the expression of HPA, the traditional HPA inhibitors may produce nonspecific and undesirable effects. In recent years, genetic approaches targeting HPA have been regarded as a promising alternative.

25 Nov 2009

Provectus Pharmaceuticals announces Phase 1 interim study data of PV-10 for metastatic melanoma

Provectus Pharmaceuticals, Inc., a development-stage oncology and dermatology biopharmaceutical company, announced today that initial one year overall survival data from the first 20 subjects in the current Phase 2 trial showed comparable trends to Phase 1 survival data.

23 Nov 2009

Cancer promoting gene identified

Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis. Scientists hope the finding could lead to an effective therapy to target and inhibit the expression of this gene resulting in inhibition of cancer growth.

21 Nov 2009

TGen Drug Development and IPC collaborate to speed up research discoveries for cancer patients

TGen Drug Development (TD2) and the Institut Paoli-Calmettes (IPC) have forged a strategic alliance that will enable both to maximize their worldwide contributions in the treatment of cancer patients.

20 Nov 2009

Metastasis News and Research

Further Reading

Galapagos NV receives milestone payment to initiate Phase I clinical trial of GLPG0555 drug

Long-chain omega-3 fatty acids can prevent colorectal cancer

Galapagos NV issues new shares

TGFb growth factor controls spread of cancer cells

'Twist' gene plays a key role in the development of breast cancer

TGen scientists win $1,000 prize for best scientific paper presented at BIBM09

Galapagos' multiple milestone achievement triggers cash payment of EUR 10.2 million

Coding guidelines for Agendia's MammaPrint test established by Palmetto GBA

Human Melanoma Research Team pursuing identification of anti-tumor prognostic markers and drugs

CT imaging combined with Avastin may predict overall survival in metastatic colorectal cancer

TGF--1 suppresses the growth of cancer cells, find researchers

DFG approves establishment of new CRCs; research topics range from modern prostheses to political reforms to marine bacteria

Researchers devise a way to deliver right therapy directly to tumors using aptamers

OSEO awards fund for Galapagos NV's antibody therapeutics program

Wnt signaling pathway plays a role in diabetic retinopathy

Wnt and EGFR signaling pathways interact to promote tumor cell invasion and metastasis

HPA-specific shRNA holds potential as a novel therapeutic strategy for gastric cancer

Provectus Pharmaceuticals announces Phase 1 interim study data of PV-10 for metastatic melanoma

Cancer promoting gene identified

TGen Drug Development and IPC collaborate to speed up research discoveries for cancer patients

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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