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Study seeks to determine environmental factors that protect against asthma, allergies

Researchers in the University of Arizona's BIO5 Institute have entered into a collaboration with Johnson & Johnson Consumer & Personal Products and Janssen Biotech Inc. to leverage foundational discovery research aimed at determining environmental factors that underlie asthma and allergies.

12 Jun 2015

Daily dose of aspirin effective at blocking breast tumor growth

"Take two aspirin and call me in the morning" has been the punchline for countless jokes. Could it also be good advice for cancer patients? A lab study to appear in the July 2015 issue of Laboratory Investigation found that a daily dose of aspirin was effective at blocking breast tumor growth. Previous studies have already shown a similar effect on colon, gastrointestinal, prostate, and other cancers.

12 Jun 2015

Common antibiotic azithromycin effectively kills many multidrug-resistant bacteria

Contrary to current medical dogma, researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences report that the common antibiotic azithromycin kills many multidrug-resistant bacteria very effectively — when tested under conditions that closely resemble the human body and its natural antimicrobial factors.

11 Jun 2015

Study on how maternal proteins help regulate initial cell divisions during early development

Researchers in the University of Georgia's Regenerative Bioscience Center are visually capturing the first process of chromosome alignment and separation at the beginning of mouse development. The findings could lead to answers to questions concerning the mechanisms leading to birth defects and chromosome instability in cancer cells.

10 Jun 2015

New research shows that low glycemic index diets reduce autism symptoms in mice

Bread, cereal and other sugary processed foods cause rapid spikes and subsequent crashes in blood sugar. In contrast, diets made up of vegetables, fruits and whole grains are healthier, in part because they take longer to digest and keep us more even-keeled.

9 Jun 2015

Stemedica receives FDA's IND approval for itMSC Phase IIa clinical trial to treat Alzheimer's disease

Stemedica Cell Technologies, Inc. received the FDA's investigational new drug (IND) approval for a United States-based, Phase IIa clinical study using its allogeneic stem-cell therapy to treat subjects with mild to moderate dementia due to Alzheimer's disease (AD), the sixth leading cause of death in the United States.

9 Jun 2015

Frankfurt researchers decode molecular details that provide better understanding of neurodegenerative diseases

Quality control is important - this is not only applicable to industrial production but also true for all life processes. However, whereas an enterprise can start a large-scale recall in case of any doubt, defects in the quality control systems of cells are often fatal.

9 Jun 2015

Researchers identify immune system marker that drives therapy-resistant prostate cancer

You are a patient who has just been treated for a serious illness but neither you nor your doctor knows how likely it is that you -- in comparison with other patients -- will actually be helped by the treatment. This is often the situation with prostate cancer, one of the deadliest and most highly prevalent cancers. While hormone therapy can help, patient responses vary widely, and it's still unclear why some types of prostate cancer seem to be resistant to the therapy.

5 Jun 2015

Oxygen regulatory pathway can act to trigger tissue regeneration in mice

A study led by Ellen Heber-Katz, PhD, of the Lankenau Institute for Medical Research, part of Main Line Health, shows that a primordial form of energy production that still exists in mammals can be harnessed to achieve spontaneous tissue regeneration in mice, without the need for added stem cells.

4 Jun 2015

Feinberg physiology professor named recipient of 2015 AES Seed Grant

Today the American Epilepsy Society announced Anis Contractor, Ph.D., Associate Professor of Physiology at Northwestern University, Feinberg School of Medicine, as the recipient of a 2015 AES Seed Grant. Dr. Contractor's proposed research seeks to address a fundamental question about cellular and circuit level excitability in the mouse model of Dravet Syndrome.

3 Jun 2015

March of Dimes funds studies that explore factors, mechanisms involved in placental malaria

Malaria infection during pregnancy poses serious risks to women and infants. The March of Dimes Foundation, an American organization that works to improve pregnancy and baby health, has now funded Carlos Penha-Goncalves' laboratory, at the Instituto Gulbenkian de Ciencia (IGC, Portugal), for their studies on factors and mechanisms involved in placental malaria. This is the first time that this American Foundation funds research from a Portuguese Institution.

3 Jun 2015

Genetically-programmed probiotics could help detect liver cancer metastases early-on

Scientists at the University of California, San Diego and the Massachusetts Institute of Technology have described a new method for detecting liver cancer metastases in mice. The approach uses over-the-counter probiotics genetically programmed to produce signals easily detectable in urine when liver cancer metastases are present.

2 Jun 2015

Researchers identify previously unknown gene mutation that causes achromatopsia

People with achromatopsia, an inherited eye disorder, see the world literally in black and white. Worse yet, their extreme sensitivity to light makes them nearly blind in bright sunlight. Now, researchers at University of California, San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health System have identified a previously unknown gene mutation that underlies this disorder.

2 Jun 2015

Previously unknown gene mutation linked to inherited eye disorder, achromatopsia

2 Jun 2015

Differences in brain expression of RORA protein levels may lead to sex bias in autism

George Washington University researcher Valerie Hu, Ph.D., has found an important sex-dependent difference in the level of RORA protein in brain tissues of males and females. Specifically, females without autism have a slightly higher level of RORA in the frontal cortex of the brain than males without autism, while the levels of the protein are comparably lower in the brain of both males and females with autism.

29 May 2015

Novel discovery offers new insight into why women more likely than men to develop MS

An innocent mistake made by a graduate student in a Northwestern Medicine lab (she accidentally used male mice instead of female mice during an experiment) has led scientists to a novel discovery that offers new insight into why women are more likely than men to develop autoimmune diseases such as multiple sclerosis (MS).

28 May 2015

Progression of different types of breast cancer influenced differently by tumor microenvironment

Our environment can have a major impact on how we develop, and it turns out it's no different for cancer cells. In work published today in Neoplasia, a team of researchers led by Associate Professor Mikala Egeblad at Cold Spring Harbor Laboratory found that two different mouse models of breast cancer progressed differently based on characteristics of the tumor microenvironment - the area of tissue in which the tumor is embedded.

28 May 2015

Carbon monoxide may actually protect the brain from damage after subarachnoid hemorrhage

Carbon monoxide is known by many as a poisonous gas that causes brain injury and other neurological symptoms, including memory loss and confusion. But a new study led by investigators at Beth Israel Deaconess Medical Center suggests the opposite may be true: When administered in small, carefully controlled amounts, carbon monoxide may actually protect the brain from damage following subarachnoid hemorrhage, a devastating stroke that results from bleeding in the brain.

27 May 2015

Mayo Clinic scientists create mouse model of ALS, FTD caused by mutations in C9ORF72 gene

Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), both of which are caused by a mutation in the a gene called C9ORF72.

24 May 2015

Decreased removal of toxic peptides causes onset of Alzheimer's disease

Jens Pahnke and his team at the University of Oslo has recently published results in the prestigious scientific journal 'BRAIN' showing that decreased removal of toxic peptides in the brain causes the onset and first clinical signs of Alzheimer's disease, rather than overproduction as has previously been assumed. This information can now be used to target specific genes to enhance their function in the brain of elderly or people at risk.

22 May 2015

Mouse Model News and Research

Study seeks to determine environmental factors that protect against asthma, allergies

Daily dose of aspirin effective at blocking breast tumor growth

Common antibiotic azithromycin effectively kills many multidrug-resistant bacteria

Study on how maternal proteins help regulate initial cell divisions during early development

New research shows that low glycemic index diets reduce autism symptoms in mice

Stemedica receives FDA's IND approval for itMSC Phase IIa clinical trial to treat Alzheimer's disease

Frankfurt researchers decode molecular details that provide better understanding of neurodegenerative diseases

Researchers identify immune system marker that drives therapy-resistant prostate cancer

Oxygen regulatory pathway can act to trigger tissue regeneration in mice

Feinberg physiology professor named recipient of 2015 AES Seed Grant

March of Dimes funds studies that explore factors, mechanisms involved in placental malaria

Genetically-programmed probiotics could help detect liver cancer metastases early-on

Researchers identify previously unknown gene mutation that causes achromatopsia

Previously unknown gene mutation linked to inherited eye disorder, achromatopsia

Differences in brain expression of RORA protein levels may lead to sex bias in autism

Novel discovery offers new insight into why women more likely than men to develop MS

Progression of different types of breast cancer influenced differently by tumor microenvironment

Carbon monoxide may actually protect the brain from damage after subarachnoid hemorrhage

Mayo Clinic scientists create mouse model of ALS, FTD caused by mutations in C9ORF72 gene

Decreased removal of toxic peptides causes onset of Alzheimer's disease

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