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HF-WBI effective for patients with early stage breast cancer

The American Society for Radiation Oncology (ASTRO) has released evidence-based guidelines to define appropriate fractionation of whole breast irradiation (WBI), finding that hypofractionated (HF) WBI is effective for many patients with early-stage breast cancer. These guidelines are published in the International Journal of Radiation Oncology-Biology-Physics, the official journal of ASTRO.

5 Aug 2010

SORT1 pathway holds promise as new target for therapeutic intervention for LDL cholesterol reduction

The true power of genomic research lies in its ability to help scientists understand biological processes, particularly those that - when altered - can lead to disease. This power is demonstrated dramatically in a pair of papers published today in the journal Nature. In the first, a global team of researchers describes 95 different variations across the genome that contribute in different degrees to alterations in blood cholesterol and triglyceride levels in multiple human populations. In the second report, close examination of just one of these common variants not only reveals the involvement of an unexpected genetic pathway in lipid metabolism but also provides a blueprint for using genomic findings to unravel biological connections between lipid levels and coronary heart disease.

5 Aug 2010

Study links sea sponge genome sequence with first animals and cancer

The sponge, which was not recognized as an animal until the 19th century, is now the simplest and most ancient group of animals to have their genome sequenced. In a paper appearing in the August 5 issue of the journal Nature, a team of researchers led by Daniel Rokhsar of the University of California, Berkeley, and the Department of Energy's Joint Genome Institute (JGI), report the draft genome sequence of the sea sponge Amphimedon queenslandica and several insights the genome gives into the origins of both the first animals and cancer.

5 Aug 2010

Detection of Alzheimer's before symptoms occur

Research is on to detect the dreaded Alzheimer's disease even before any symptoms occur. In a newly proposed diagnostic criteria developed by experts from the National Institute on Aging and the Alzheimer's Association three stages of the disease viz. pre-clinical Alzheimer's, mild cognitive impairment and Alzheimer's dementia are described.

4 Aug 2010

Scientists identify 95 gene loci that influence lipoprotein metabolism in humans

In a large-scale international study in which Helmholtz Zentrum München participated, scientists have identified 95 gene loci which influence lipoprotein metabolism in humans. Viewed from a long-term perspective, these findings open up new lines of research in the prevention and treatment of coronary artery disease. It is the first genome-wide association study of this kind to be published in the prestigious journal Nature.

4 Aug 2010

Blood coagulation, antimicrobial defence processes are functionally coupled: Research

The adaptive immune system can recognize and respond specifically to particular infectious agents. But the first line of defence against pathogens is the so-called innate immune system. This system reacts to invaders by initiating unspecific inflammatory responses which attract various types of specialized cells such as neutrophils to the site of the incursion.

4 Aug 2010

Foreign doctors provide care as good as that of Americans, study finds

Physicians trained in other countries provide care just as good as -- and perhaps better than some U.S. doctors, a report published in the journal Health Affairs found.

4 Aug 2010

Research findings show normal rise and fall in triglycerides

When the circadian rhythm gets thrown off, it could come with an unexpected side effect: high triglycerides. The discovery, based on studies in mice with a "broken clock," helps to explain the normal rise and fall in triglycerides, which happens at about the same time each day, according to researchers who report their findings in the August issue of Cell Metabolism, a Cell Press publication.

4 Aug 2010

Celera decreases second-quarter net loss to $6.1 million

Celera Corporation today reported net revenues of $32.6 million for the second quarter of 2010 that ended June 26, 2010, compared to $41.4 million for the prior year quarter. For the second quarter of 2010, Celera reported a net loss of $6.1 million, or $0.07 per share, compared to a net loss of $31.7 million, or $0.39 per share, for the prior year quarter.

4 Aug 2010

BCM collaborates with Roche NimbleGen for high throughput exome capture technology

The Baylor College of Medicine Human Genome Sequencing Center has standardized its target enrichment human disease research studies on Roche NimbleGen Sequence Capture Exome technology. The Baylor HGSC will sequence over 5,000 exomes in the next two years to identify genetic variants underlying multiple human diseases and will employ NimbleGen SeqCap EZ Exome and customized NimbleGen exome designs as the exome capture technology of choice. More than 15 different diseases will be investigated by Baylor HGSC, including brain, liver, pancreatic, colon, ovarian and bladder cancers, heart disease, diabetes, autism, and other inherited diseases with the goal of better understanding causative mutations and their impact on these diseases.

4 Aug 2010

AGA Medical second-quarter 2010 net sales increase 7.6% to $53.8 million

AGA Medical Holdings, Inc., a leading developer of interventional medical devices for the minimally invasive treatment of structural heart defects and vascular abnormalities, today reported financial results for the second quarter ended June 30, 2010.

3 Aug 2010

Kopin second-quarter total sales increase 7.0% to $30.2 million

Kopin Corporation today announced financial results for the second quarter ended June 26, 2010.

3 Aug 2010

Investigators explore legal, ethical permissibility of carrying out request specific to VAD

Patients have the right to refuse or request the withdrawal of any unwanted treatment. In an article published in the online issue of Mayo Clinic Proceedings, investigators explore the legal and ethical permissibility of carrying out such a request specific to a ventricular assist device.

3 Aug 2010

Acorda second-quarter net loss decreases to $6.8 million

Acorda Therapeutics, Inc. today announced its financial results for the second quarter of 2010.

3 Aug 2010

Menstrual cycle affects body's response to tracheal intubation: Research

In women undergoing surgery, the heart rate and blood pressure response to ventilation tube placement varies at different times of the menstrual cycle, according to a study in the August issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

3 Aug 2010

Americans halved their risk of dying from CHD over past 20 years: Study

By smoking less, watching their cholesterol and lowering their high blood pressure, Americans halved their risk of dying from coronary heart disease over the past 20 years, a new study shows.

3 Aug 2010

Emerging Healthcare Solutions executes Term Sheet with Stand-By Systems

Emerging Healthcare Solutions, Inc. disclosed today that the Company has executed a Term Sheet with Stand-By Systems. The Term Sheet represents successful negotiations between the two companies just ahead of finalizing a Definitive Agreement. Stand-By Systems (SBS) owns the FDA approved SBS 1615 catalytic oxygen generator and associated systems. This cutting edge generator provides medical grade USP oxygen at the push of a button from self-contained inert dry compounds.

3 Aug 2010

Bypass better strategy for treating progressive, complex recurrent SFA disease: Study

Researchers from The Methodist Hospital's DeBakey Heart and Vascular Center in Houston, Texas have studied outcomes of patients who had endovascular and open interventions for recurrent superficial femoral artery (SFA) occlusive disease. Results of their work are detailed in the August issue of the Society for Vascular Surgery's® Journal of Vascular Surgery®.

3 Aug 2010

Healthy heart may slow down aging of brain: Study

Keep your heart healthy and you may slow down the aging of your brain, according to a new study reported in Circulation: Journal of the American Heart Association.In the study, people whose hearts pumped less blood had brains that appeared older than the brains of those whose hearts pumped more blood. Decreased cardiac index, the amount of blood that pumps from the heart in relation to a person's body size, was associated with decreased brain volume using magnetic resonance imaging (MRI).

3 Aug 2010

Vanguard signs definitive agreement to acquire Arizona Heart Institute

Vanguard Health Systems and Arizona Heart Institute (AHI) announced today that they have signed a definitive agreement for Vanguard to acquire Arizona Heart Institute, one of the world's leading providers of cardiovascular care. Through this agreement, AHI will align with Abrazo Health Care, a Phoenix-based subsidiary of Vanguard, to become part of its distributive cardiovascular network of community-based physicians, providing future opportunities to greatly expand cardiovascular services and patient base throughout the region.

3 Aug 2010