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Scientists identify novel gene mutation that causes glioblastoma

Scientists at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center, in collaboration with colleagues in Boston and South Korea, say they have identified a novel gene mutation that causes at least one form of glioblastoma (GBM), the most common type of malignant brain tumor.

18 Nov 2011

Merrimack initiates MM-121 Phase 2 combination trial in metastatic NSCLC

Merrimack Pharmaceuticals, Inc. announced today that the first patient has been dosed in a Phase 2 clinical trial of MM-121, a fully human monoclonal antibody that targets ErbB3, in combination with erlotinib, a small molecule directed at the epidermal growth factor receptor (EGFR), in three groups of patients with metastatic non-small cell lung cancer.

18 Nov 2011

Deep brain stimulation benefits highly treatment resistant patients with major depressive disorder

Results from the first multi-center pilot study of deep brain stimulation (DBS) for major depressive disorder were published online today by the Journal of Neurosurgery. The study, conducted at three research facilities in Canada, was designed to replicate and build upon an earlier study by Dr. Andres Lozano and Dr. Helen Mayberg which was published in the journal Neuron in 2005.

18 Nov 2011

FDA assigns new PDUFA date for Takeda's investigational type 2 diabetes therapy, alogliptin

Takeda Pharmaceutical Company Limited and its wholly-owned subsidiary, Takeda Global Research & Development Center, Inc., U.S., today announced that the company received notification from the U.S. Food and Drug Administration (FDA) that its review of investigational type 2 diabetes therapy alogliptin, and thus the fixed-dose combination therapy alogliptin/pioglitazone, will be delayed.

18 Nov 2011

HVTN debunks top 10 myths about HIV vaccine research

Dec. 1 is World AIDS Day, and in commemoration of the occasion, the HIV Vaccine Trials Network, headquartered at Fred Hutchinson Cancer Research Center, debunks the top 10 myths about HIV vaccine research.

18 Nov 2011

H2S plays a major role in protecting bacteria from effects of different antibiotics

Although scientists have known for centuries that many bacteria produce hydrogen sulfide (H2S) it was thought to be simply a toxic by-product of cellular activity. Now, researchers at NYU School of Medicine have discovered H2S in fact plays a major role in protecting bacteria from the effects of numerous different antibiotics.

18 Nov 2011

Important clues to prevention and management of delirium are being ignored

Important clues to the prevention and management of delirium, a condition affecting an estimated 7 million hospitalized Americans, are being ignored, according to a study from the Regenstrief Institute and the Indiana University School of Medicine.

18 Nov 2011

UK to offer master's degree in music therapy

The University of Kentucky will be the first higher education institution in the Commonwealth of Kentucky to offer a graduate degree in music therapy. The program, housed at the UK School of Music, was officially approved by the state's Council on Postsecondary Education earlier in November and will start accepting graduate students in the spring of 2012.

18 Nov 2011

Flying Start NHS increases clinical skills development, confidence in newly qualified practitioners

Newly qualified nurses, midwives and allied health professionals who took part in an online course during their first year of employment reported increased clinical skills development and confidence. However the survey on the Flying Start NHS programme, published in the December issue of the Journal of Clinical Nursing, found that mentors needed more training and time to provide support.

18 Nov 2011

University of Haifa leads new computerized medical information systems research project

University of Haifa leads a new international computerized medical information systems research project, funded by the EU with total budget of €6 million.

18 Nov 2011

NYU Langone cardiovascular experts present new research findings at AHA 2011

Experts from the Cardiac & Vascular Institute at NYU Langone Medical Center presented new research findings at the American Heart Association Scientific Sessions 2011 held November 12-16, 2011 in Orlando, Florida.

18 Nov 2011

Blocking CaM kinase may help prevent cardiac rupture

For people who initially survive a heart attack, a significant cause of death in the next few days is cardiac rupture -- literally, bursting of the heart wall. A new study by University of Iowa researchers pinpoints a single protein as the key player in the biochemical cascade that leads to cardiac rupture.

18 Nov 2011

VSL#3 classified as refrigerated medical food for three GI conditions

As clinical studies continue to validate the use of probiotics to help promote general gastrointestinal health, a growing U.S. market for probiotics indicates that the U.S. healthcare community and consumers alike are recognizing the value of these beneficial microorganisms. However, because most probiotics are classified as dietary supplements, directing patients to the best probiotic for their individual needs can be challenging.

18 Nov 2011

MU scientist examines how enzymes influence immune system's ability to fight infection

The influenza virus remains a worldwide threat to humans, causing an average of 36,000 deaths and 200,000 hospitalizations each year in the United States alone. As health care professionals prepare for another flu season, a University of Missouri scientist is studying how two enzymes could be used to stop the virus in its tracks.

18 Nov 2011

New white paper on potential role of EBTs in treating obesity

The American Society for Gastrointestinal Endoscopy (ASGE) and the American Society for Metabolic & Bariatric Surgery (ASMBS) have issued a new white paper on the potential role of endoscopic bariatric therapies (EBTs) in treating obesity and obesity-related diseases like Type 2 diabetes.

18 Nov 2011

Chloroquine-chemotherapy combination holds potential for metastatic breast cancer treatment

An anti-malaria drug used for more than 60 years is now being studied for use in breast cancer patients whose disease has not responded to traditional chemotherapy treatment.

18 Nov 2011

EC approves Pfizer's Vyndaqel to treat Transthyretin Familial Amyloid Polyneuropathy

Pfizer announced today that the European Commission has approved Vyndaqel (tafamidis) for the treatment of Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP) in adult patients with stage 1 symptomatic polyneuropathy.

17 Nov 2011

Hemoglobin levels, blood pressure and male gender linked to higher risk of silent strokes in SCA children

Factors such as low hemoglobin levels, increased systolic blood pressure, and male gender are linked to a higher risk of silent cerebral infarcts (SCIs), or silent strokes, in children with sickle cell anemia (SCA), according to results from a large, first-of-its-kind study published online today in Blood, the Journal of the American Society of Hematology (ASH).

17 Nov 2011

Stem cell therapy for heart failure: two studies two successes

The Center for Disease Control and Prevention says that heart failure affects nearly 6 million Americans leading to considerable risk of death, diminished quality of like and recurrent hospitalizations. Heart failure occurs when the heart can no longer pump enough blood to the rest of the body. The most common cause of heart failure is coronary artery disease, which narrows the small blood vessels that supply blood and oxygen to the heart.

17 Nov 2011

LGBT seniors face higher rates of disability, physical and mental distress

Aging and health issues facing lesbian, gay, bisexual and transgender baby boomers have been largely ignored by services, policies and research. These seniors face higher rates of disability, physical and mental distress and a lack of access to services, according to the first study on aging and health in these communities.

17 Nov 2011

Therapy News and Research

Scientists identify novel gene mutation that causes glioblastoma

Merrimack initiates MM-121 Phase 2 combination trial in metastatic NSCLC

Deep brain stimulation benefits highly treatment resistant patients with major depressive disorder

FDA assigns new PDUFA date for Takeda's investigational type 2 diabetes therapy, alogliptin

HVTN debunks top 10 myths about HIV vaccine research

H2S plays a major role in protecting bacteria from effects of different antibiotics

Important clues to prevention and management of delirium are being ignored

UK to offer master's degree in music therapy

Flying Start NHS increases clinical skills development, confidence in newly qualified practitioners

University of Haifa leads new computerized medical information systems research project

NYU Langone cardiovascular experts present new research findings at AHA 2011

Blocking CaM kinase may help prevent cardiac rupture

VSL#3 classified as refrigerated medical food for three GI conditions

MU scientist examines how enzymes influence immune system's ability to fight infection

New white paper on potential role of EBTs in treating obesity

Chloroquine-chemotherapy combination holds potential for metastatic breast cancer treatment

EC approves Pfizer's Vyndaqel to treat Transthyretin Familial Amyloid Polyneuropathy

Hemoglobin levels, blood pressure and male gender linked to higher risk of silent strokes in SCA children

Stem cell therapy for heart failure: two studies two successes

LGBT seniors face higher rates of disability, physical and mental distress

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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