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Scientists use metabolomics to discover DMS linked with neuropathic pain

Millions of people worldwide suffer from a type of chronic pain called neuropathic pain, which is triggered by nerve damage. Precisely how this pain persists has been a mystery, and current treatments are largely ineffective. But a team led by scientists from The Scripps Research Institute, using a new approach known as metabolomics, has now discovered a major clue: dimethylsphingosine (DMS), a small-molecule byproduct of cellular membranes in the nervous system.

23 Jan 2012

Defect in neuronal RNA splicing process may contribute to neurological disease

A Jackson Laboratory research team led by Professor and Howard Hughes Medical Investigator Susan Ackerman, Ph.D., has discovered a defect in the RNA splicing process in neurons that may contribute to neurological disease.

20 Jan 2012

Research on neuron interaction could lead to potential treatment for addiction

Harvard scientists have developed the fullest picture yet of how neurons in the brain interact to reinforce behaviors ranging from learning to drug use, a finding that might open the door to possible breakthroughs in the treatment of addiction.

19 Jan 2012

Defects in mitochondria lead to devastating neurodegenerative disease

A devastating neurodegenerative disease that first appears in toddlers just as they are beginning to walk has been traced to defects in mitochondria, the 'batteries' or energy-producing power plants of cells. This finding by a team of researchers, led by investigators from the Montreal Neurological Institute and Hospital - The Neuro- at McGill University, was published in this week's issue of the Proceedings of the National Academy of Sciences of the USA.

18 Jan 2012

Stem cell transplantation prevents further traumatic axonal injury

For years, researchers seeking new therapies for traumatic brain injury have been tantalized by the results of animal experiments with stem cells. In numerous studies, stem cell implantation has substantially improved brain function in experimental animals with brain trauma. But just how these improvements occur has remained a mystery.

13 Jan 2012

Insight into brain mechanism that limits rewarding impact of cocaine

Research published by Cell Press in the January 12 issue of the journal Neuron provides fascinating insight into a newly discovered brain mechanism that limits the rewarding impact of cocaine. The study describes protective delayed mechanism that turns off the genes that support the development of addiction-related behaviors.

12 Jan 2012

Scientists investigate specific role of IT neurons in 3D perception

The incredible ability of our brain to create a three-dimensional (3D) representation from an object's two-dimensional projection on the retina is something that we may take for granted, but the process is not well understood and is likely to be highly complex. Now, new research published by Cell Press in the January 12 issue of the journal Neuron provides the first direct evidence that specific brain areas underlie perception of different 3D structures and sheds light the way that the primate brain reconstructs real-world objects.

11 Jan 2012

Study finds no support for primary pathogenic role of LBs in PD

The pathology of Parkinson's disease is characterized by a loss of dopamine-producing neurons in the pars compacta of the substantia nigra (SN), an area of the brain associated with motor control, along with the development of α-synuclein (αS) protein in the form of Lewy bodies (LB) in the neurons that survive. The spread of LB pathology is thought to progress along with the clinical course of Parkinson's disease, although recent studies suggest that they are not the toxic cause of cell death.

10 Jan 2012

Scientists map neurons that process different kinds of visual information

There's a 3-D world in our brains. It's a landscape that mimics the outside world, where the objects we see exist as collections of neural circuits and electrical impulses.

7 Jan 2012

Research reveals how bats parse duties at single neuron level

Imagine listening to music while carrying on a conversation with friends. This type of multi-tasking is fairly easy to do, right? That's because our brains efficiently and effectively separate the auditory signals - music to the right side; conversation to the left. But what researchers have not been able to do in humans or animals is to see a parsing of duties at the single neuron level - until now.

4 Jan 2012

Glia cells also regulate learning and memory

Glia cells, named for the Greek word for "glue," hold the brain's neurons together and protect the cells that determine our thoughts and behaviors, but scientists have long puzzled over their prominence in the activities of the brain dedicated to learning and memory.

30 Dec 2011

First picture of how specialized neurons are organized in hairy skin

Compared to our other senses, scientists don't know much about how our skin is wired for the sensation of touch. Now, research reported in the December 23rd issue of the journal Cell, a Cell Press publication, provides the first picture of how specialized neurons feel light touches, like a brush of movement or a vibration, are organized in hairy skin.

23 Dec 2011

Researchers discover that humans are natural-born multi-taskers

Imagine you're a hockey goalie, and two opposing players are breaking in alone on you, passing the puck back and forth. You're aware of the linesman skating in on your left, but pay him no mind. Your focus is on the puck and the two approaching players. As the action unfolds, how is your brain processing this intense moment of "multi-tasking"? Are you splitting your focus of attention into multiple "spotlights?" Are you using one "spotlight" and switching between objects very quickly? Or are you "zooming out" the spotlight and taking it all in at once?

22 Dec 2011

CNVs appear to play a significant role in early onset bipolar disorder

An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, reports that abnormal sequences of DNA known as rare copy number variants, or CNVs, appear to play a significant role in the risk for early onset bipolar disorder.

22 Dec 2011

ORNL tool reveals previously undiscovered role of retinoblastoma

Armed with a new ability to find retinal anomalies at the cellular level, neurobiologists at St. Jude Children's Research Hospital have made a discovery they hope will ultimately lead to a treatment for cancer of the retina.

22 Dec 2011

Researchers discover how spinning microparticles can direct neuron growth

Researchers at UC Irvine and The University of Texas at Arlington have discovered how spinning microparticles can direct the growth of nerve fiber, a discovery that could allow for directed growth of neuronal networks on a chip and improve methods for treating spinal or brain injuries.

21 Dec 2011

ALS TDI, Biogen Idec and UCB enter agreement to study anti-CD40L antibody for ALS

The ALS Therapy Development Institute today announced a research agreement with Biogen Idec and UCB Pharma SA to investigate the use of an anti-CD40L antibody as a potential therapy for Amyotrophic Lateral Sclerosis, also known as Lou Gehrig's or Motor Neuron Disease.

19 Dec 2011