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Study finds BRCA1 mutations in nearly one in five TN breast cancer patients

Leading breast cancer experts are calling for women under 50 who are diagnosed with triple-negative (TN) breast cancer to be offered testing for faults in the BRCA1 gene, according to a report published in the British Journal of Cancer.

15 Feb 2012

President Obama releases FY13 budget proposal with overall decrease for GHI

"President Barack Obama on Monday proposed a $3.8 trillion budget for fiscal 2013 that aims to slash the deficit by $4 trillion over 10 years," the Associated Press reports, and provides an agency-by-agency breakdown of the proposed budget.

15 Feb 2012

Viewpoints: Obama's budget, birth control choices; Planning hospital readmissions to save

In poll after poll, the public has made clear that it prefers the president's approach of rebuilding the economy now and tackling the deficit when the fundamentals are stronger. While Republicans have counted on voters blaming Mr. Obama for the hard times, some are beginning to worry that they will be blamed for their obstructionism.

15 Feb 2012

Steady increase in Low Molecular Weight Heparin use for blood clots: Study

The use of an injectable, clot-preventing drug known as Low Molecular Weight Heparin to treat patients with advanced cancer complicated by blood clots increased steadily between 2000 and 2007, according to a new study published in The Oncologist, funded by the National Cancer Institute and led by Kaiser Permanente Colorado.

15 Feb 2012

Researchers investigate role of a MYC family gene in ovarian cancer

The role of a known cancer-causing gene in the development of the most lethal type of ovarian cancer is being investigated by researchers from the Walter and Eliza Hall Institute after they were awarded a Cure Cancer Australia Foundation (CCAF) grant.

15 Feb 2012

Moffitt receives patent for computerized system designed to improve clinical trial selection

A new patent has been issued to Moffitt Cancer Center for a computerized system that efficiently selects the right patient for the right clinical trial. The newly patented system matches the registered patient's own molecular profile - warehoused in a database of thousands of patient-donated biological tissue or tumor samples - to the molecular design of the drug aimed at targeting their disease at the molecular level, and does it quickly.

15 Feb 2012

New group of compounds may protect brain cells from inflammation

Scientists at Emory University School of Medicine have identified a new group of compounds that may protect brain cells from inflammation linked to seizures and neurodegenerative diseases.

15 Feb 2012

Aganirsen demonstrates significant activity in two models of wet AMD, ischemic retinopathy

Gene Signal, a company focused on developing innovative drugs to manage angiogenesis based conditions, today announced the publication of data demonstrating the significant activity of aganirsen (GS-101, eye drops) in two important models of retinal neovascular disease, wet age-related macular degeneration (AMD) and ischemic retinopathy.

15 Feb 2012

New WSU model system focuses on causes of everyday MS symptoms

Annoying, frustrating symptoms like difficulty hearing or remembering things can complicate everyday living for multiple sclerosis (MS) patients, but most research to date has focused on the disease's less frequent but more debilitating consequences.

15 Feb 2012

Antibiotic prescriptions do not reduce sinus symptoms

Antibiotics that doctors typically prescribe for sinus infections do not reduce symptoms any better than an inactive placebo, according to investigators at Washington University School of Medicine in St. Louis.

15 Feb 2012

AGS honors IU professor for outstanding achievement in geriatric care

In recognition of his significant contributions to the health care of older adults, Regenstrief Institute investigator Malaz Boustani, M.D., MPH, associate professor of medicine at the Indiana University School of Medicine, will receive the 2012 American Geriatrics Society Outstanding Scientific Achievement for Clinical Investigation Award.

15 Feb 2012

Diffusion-weighted MRI may effectively indicate response to ovarian cancer treatment

Cancer Research UK-funded scientists have determined that a magnetic resonance imaging (MRI) technique, which measures the movement of water molecules within the tumour, may be the best way to monitor how women with late-stage ovarian cancer are responding to treatment. The study is published in the journal Radiology today.

14 Feb 2012

Canada organ donation rates plateau

A report released Monday by the Canadian Institute for Health Information reveals that public awareness campaigns and stories of grateful organ recipients have not done much to improve the number of organ donations in Canada. Donor rates have stagnated in the country since 2006 while thousands of Canadians continue to languish on wait lists for organs, the report adds.

14 Feb 2012

Brain tissue created from human skin cells

British scientists have successfully generated brain tissue from human skin. The team has for the first time generated a crucial type of brain cells in the laboratory by reprogramming skin cells. They say it could speed up the hunt for new treatments for conditions such as Alzheimer's disease, epilepsy and stroke.

14 Feb 2012

Aspirin-like drugs help prevent spread of tumors in the body

Australian scientists have made a breakthrough which could help in the fight against cancer. The team from Peter MacCallum Cancer Centre in Melbourne has found a link between non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, and the ability of tumours to spread in the body. They say that doctors have been aware of the benefits of NSAIDs for many years, but did not fully understand the biological processes involved.

14 Feb 2012

Juvenile arthritis affected kids are at a high risk of cancer: Study

A new study shows that kids with juvenile idiopathic arthritis develop cancer four times more often than children without the disease, but the treatments they receive - including biologic treatments like Enbrel - may not explain their increased risk. If confirmed, researchers say the findings should ease fears that biologic treatments known as TNF inhibitors cause cancer in children and young adults.

14 Feb 2012

Scientific conference on considerations for NBCD regulatory approval pathway

The U.S. Food and Drug Administration (FDA) is currently working toward implementing the Biologics Price Competition and Innovation Act (BPCI) of 2009, which establishes an abbreviated approval pathway for biological products that are demonstrated to be "highly similar" to or "interchangeable" with a drug regulated under the Public Health Service Act.

14 Feb 2012

New light on treatment targets for potentially life-threatening cardiac arrhythmia conditions

That flutter in your heart may have more to do with the movement of sodium ions than the glance of a certain someone across a crowded room.

14 Feb 2012

'Targeted' drugs may be effective against lung and colorectal tumors driven by novel gene abnormalities

Novel gene abnormalities discovered in a subpopulation of lung and colorectal tumors could potentially identify patients with a good chance of responding to highly specific "targeted" drugs already in use for treating other cancers, scientists report.

14 Feb 2012

Mich. Attorney General to sue administration on birth control rule

While officials at some hospitals and universities expressed support for Obama administration's compromise last week, other religious and governmental leaders remained unsatisfied, according to media reports.

14 Feb 2012