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Research reveals that a viral toxin may contribute to the severity of COVID-19

Researchers determine whether the SARS-CoV-2 spike protein influences endothelial and epithelial barrier dysfunction and vascular leakage.

14 Dec 2022

The therapeutic effects and safety of psychedelics

Psychedelics are reported to have rapid-onset and long-lasting therapeutic benefits after a single or few doses.

14 Dec 2022

The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

Researchers elucidated the mechanisms of long-term T lymphocyte lodgement in tissues other than lymphoid tissues and the reasons for the transient residency of specific subsets of tissue-resident memory T (TRM) lymphocytes.

14 Dec 2022

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Researchers isolated SARS-CoV-2 spike protein-targeted mAbs from convalescent healthcare workers, emphasizing the IGHV1-69 gene, the gene with the greatest structural and allelic variation.

14 Dec 2022

Study uncovers a new immune culprit in Alzheimer’s disease

The reason your three-pound brain doesn't feel heavy is because it floats in a reservoir of cerebrospinal fluid (CSF), which flows in and around your brain and spinal cord.

13 Dec 2022

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

In a recent study posted to the medRxiv* preprint server, researchers in Australia and Switzerland evaluated the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in community-based settings of the United States (US).

13 Dec 2022

Obesity and type 2 diabetes impair mRNA COVID vaccine efficacy in mouse model

In a recent study posted to bioRxiv*, researchers in the United States assessed the impact of metabolic diseases on coronavirus disease 2019 (COVID-19) vaccine immunogenicity in a mouse model.

13 Dec 2022

'Cellular glue' opens the door to building tissues and organs

Researchers at UC San Francisco have engineered molecules that act like "cellular glue," allowing them to direct in precise fashion how cells bond with each other.

13 Dec 2022

Scientists identify molecules in mucus that can block cholera infection

MIT researchers have identified molecules found in mucus that can block cholera infection by interfering with the genes that cause the microbe to switch into a harmful state.

13 Dec 2022

Nanomaterial can indirectly affect the immune system via the gut microbiome, study shows

The nanomaterial graphene oxide - which is used in everything from electronics to sensors for biomolecules - can indirectly affect the immune system via the gut microbiome, as shown in a new study on zebrafish by researchers at Karolinska Institutet in Sweden.

12 Dec 2022

COVID-19 vaccination temporarily alters heart rate variability

HRV parameters after COVID-19 vaccination show significant short-term changes that may persist for up to three days until ultimately returning to baseline.

12 Dec 2022

How human cell atlases provide the missing links between genes, diseases and therapies

A Nature Medicine journal perspective article describes the potential of cell atlases in shaping the future of medicine. Providing the missing link between genes and diseases, single-cell atlases make it possible to develop more precise and specific diagnostic tools by understanding the mechanisms of complex diseases.

12 Dec 2022

Immunogenicity of SARS-CoV-2 antibody response in immune naïve children and adults

Researchers compare the contribution of antibodies against the SARS-CoV-2 receptor binding domain in vaccinated and naturally infected adults and children.

12 Dec 2022

Study provides new insights for the future development of oral insulin pill

WEHI researchers in Melbourne have answered a 100-year-old question in diabetes research: can a molecule different to insulin have the same effect? The findings provide important insights for the future development of an oral insulin pill.

12 Dec 2022

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

A patient with relapsed T cell leukemia has been given base-edited T-cells in a world-first use of a base-edited cell therapy, in a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).

12 Dec 2022

Bioengineered soluble ACE2 for brain protection against SARS-CoV-2 infection

Researchers compared the efficiency of bioengineered soluble ACE-2 concerning brain protection during COVID-19.

12 Dec 2022

Off-the-shelf immunotherapy could offer new hope for patients with hard-to-treat multiple myeloma

A new therapy that makes the immune system kill bone marrow cancer cells was successful in as many as 73 percent of patients in two clinical trials, according to researchers from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai.

12 Dec 2022

Receptor News and Research

Research reveals that a viral toxin may contribute to the severity of COVID-19

The therapeutic effects and safety of psychedelics

The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Study uncovers a new immune culprit in Alzheimer’s disease

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

Obesity and type 2 diabetes impair mRNA COVID vaccine efficacy in mouse model

'Cellular glue' opens the door to building tissues and organs

Scientists identify molecules in mucus that can block cholera infection

Nanomaterial can indirectly affect the immune system via the gut microbiome, study shows

COVID-19 vaccination temporarily alters heart rate variability

How human cell atlases provide the missing links between genes, diseases and therapies

Immunogenicity of SARS-CoV-2 antibody response in immune naïve children and adults

Study provides new insights for the future development of oral insulin pill

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

Bioengineered soluble ACE2 for brain protection against SARS-CoV-2 infection

Off-the-shelf immunotherapy could offer new hope for patients with hard-to-treat multiple myeloma

Intranasal recombinant MVA-based vaccines effective against SARS-CoV-2 variants in mice

How convergent evolution is creating new COVID-19 waves

SARS-CoV-1 and SARS-CoV-2 spike proteins utilize different mechanisms to bind to ACE2

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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