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Researchers find kidney-specific gene defects may increase risk of heart failure

Scientists have identified the first DNA sequence variant common in the population that is not only associated with an increased risk of heart failure, but appears to play a role in causing it.

18 Jan 2011

Inflammation “master switch” found: Study

According to the latest medical discovery a protein that acts as a “master switch” has been found to determine whether certain white blood cells will boost or dampen inflammation. This may open new avenues in rheumatoid arthritis research. Rheumatoid arthritis or RA is an inflammatory disease that causes severe progressive crippling of the joints.

17 Jan 2011

Scientists demonstrate mechanism that explains why PSA levels promote prostate cancer

Researchers at the Duke Cancer Institute who have been studying prostate cancer cells for decades now think they know why PSA levels reflect cancer progression.

14 Jan 2011

Study highlights role of SIRT1 protein as tumor suppressor in prostate cancer

Researchers from the Kimmel Cancer Center at Jefferson and two other institutions have discovered new evidence that suggests the "longevity" protein SIRT1, known for its life-spanning effects in different species, can inhibit the development of a known precursor to prostate cancer, prostatic intraepithelial neoplasia.

14 Jan 2011

Researchers discover molecular mechanism behind coffee's protective effect

Coffee, that morning elixir, may give us an early jump-start to the day, but numerous studies have shown that it also may be protective against type 2 diabetes. Yet no one has really understood why.

14 Jan 2011

Bill and Melinda Gates Foundation grants $1.5million to Liverpool University for bacterial study

A University of Liverpool-led consortium has received $1.5million from the Bill & Melinda Gates Foundation to study a bacterium that causes serious disease and epidemics in sub-Saharan Africa.

14 Jan 2011

New research shows enzyme-armed oncolytic virus may help fight brain tumors

New research shows that oncolytic viruses, which are engineered to destroy cancer cells, might be more effective in treating deadly brain tumors if equipped with an enzyme that helps them penetrate the tumor.

13 Jan 2011

AAAS elevates Dartmouth professors to rank of Fellow

The American Association for the Advancement of Science (AAAS) has elevated four Dartmouth professors to the rank of Fellow, including three members of the faculty of Dartmouth Medical School.

13 Jan 2011

Scientists demonstrate how one gene evolves two competing functions via duplication

Researchers report that they are the first to show in molecular detail how one gene evolved two competing functions that eventually split up - via gene duplication - to pursue their separate destinies.

13 Jan 2011

Genetic information from Guthrie cards may serve as valuable resource to diagnose infant diseases

Van Andel Research Institute researchers have developed a method that can yield more information from archived newborn blood that has implications for a vast array of research, including population health studies and answering questions about diseases in infants and children.

13 Jan 2011

Study supports use of PRX as an anti-cataract agent

Scientists are reporting a scientific basis for the long-standing belief that a widely used non-prescription drug in China and certain other countries can prevent and treat cataracts, a clouding of the lens of the eye that is a leading cause of vision loss worldwide. Their study appears in Inorganic Chemistry, an ACS journal.

13 Jan 2011

Brain cell destroying genetic mechanism responsible for development of AD

Researchers at the University of British Columbia and Vancouver Coastal Health Research Institute have discovered that the genetic mechanism which destroys brain cells is responsible for early development of Alzheimer's Disease in people with Down Syndrome and for development of Alzheimer's Disease in general population - providing a potential new target for drugs that could forestall dementia in people with either condition.

13 Jan 2011

7,8-Dihydroxyflavone holds potential for treatment of fear based disorders

Living a traumatic experience favours the persistence of fear associated with an aversive stimulus, known as fear conditioning and such effect, in mice, can be suppressed with a single dosis of 7,8-Dihydroxyflavone, a type of flavonoid which boosts the ability to acquire new emotional learnings.

13 Jan 2011

TKM-PLK1 drug may offer hope for patients with advanced solid tumor cancers

A new investigational drug designed to stop cancer cells from reproducing may offer hope for patients with advanced solid tumor cancers. Clinical trials of TKM-PLK1 for qualified patients are now open at the Virginia G. Piper Cancer Center at Scottsdale Healthcare.

13 Jan 2011

New discovery has brought dream of transforming measles virus against cancer

When most people in the developed world think of measles, what comes to mind is only a dim memory of a vaccination at a pediatrician's office. But while childhood vaccination has virtually eliminated measles from North America and much of Europe, researchers remain interested in the virus.

13 Jan 2011

Aβ, tau and Fyn protein interactions may lead to brain dysfunction and AD

Though the cause of Alzheimer's disease still is unknown, recent studies have implicated three proteins strongly in its onset. New research from the University of Alabama at Birmingham, the Gladstone Institutes and the Baylor College of Medicine indicates that interactions between those three proteins might lead to brain dysfunction and AD in a mouse model of the disease.

13 Jan 2011

Obesity in children today may contribute to 2-5 year decline in life expectancy

For the first time in history, the next generation will not live longer, or even as long, as their parents. "Diseases such as Type II diabetes, high blood pressure, heart conditions and joint deterioration - what were once considered 'adult' diseases - are regularly being diagnosed in children, due to the prevalence of obesity," said Jessica Bartfield, MD, internal medicine and medical weight-loss specialist at Gottlieb Memorial Hospital, part of the Loyola University Health System.

13 Jan 2011

Micromet, MedImmune initiate MT111 Phase 1 trial in patients with advanced gastrointestinal cancer

MedImmune, the global biologics unit of AstraZeneca PLC and Micromet, today announced the initiation of a Phase 1 trial of MEDI-565 in patients with advanced gastrointestinal cancers. MEDI-565 is a BiTE antibody designed to direct a patient's T cells, the body's most potent killer cells, against cancer cells that express carcinoembryonic antigen.

13 Jan 2011

Study indicates disease's underlying causes in mice, finds compounds that normalize Alzheimer's brain

A Blanchette Rockefeller Neurosciences Institute study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States.

12 Jan 2011

Lipoprotein receptor LRP1 also regulates food intake and energy balance in central nervous system: Study

A study by researchers at Mayo Clinic's campus in Florida and Washington University School of Medicine adds a new twist to the body of evidence suggesting human obesity is due in part to genetic factors. While studying hormone receptors in laboratory mice, neuroscientists identified a new molecular player responsible for the regulation of appetite and metabolism.

12 Jan 2011

Protein C News and Research

Researchers find kidney-specific gene defects may increase risk of heart failure

Inflammation “master switch” found: Study

Scientists demonstrate mechanism that explains why PSA levels promote prostate cancer

Study highlights role of SIRT1 protein as tumor suppressor in prostate cancer

Researchers discover molecular mechanism behind coffee's protective effect

Bill and Melinda Gates Foundation grants $1.5million to Liverpool University for bacterial study

New research shows enzyme-armed oncolytic virus may help fight brain tumors

AAAS elevates Dartmouth professors to rank of Fellow

Scientists demonstrate how one gene evolves two competing functions via duplication

Genetic information from Guthrie cards may serve as valuable resource to diagnose infant diseases

Study supports use of PRX as an anti-cataract agent

Brain cell destroying genetic mechanism responsible for development of AD

7,8-Dihydroxyflavone holds potential for treatment of fear based disorders

TKM-PLK1 drug may offer hope for patients with advanced solid tumor cancers

New discovery has brought dream of transforming measles virus against cancer

Aβ, tau and Fyn protein interactions may lead to brain dysfunction and AD

Obesity in children today may contribute to 2-5 year decline in life expectancy

Micromet, MedImmune initiate MT111 Phase 1 trial in patients with advanced gastrointestinal cancer

Study indicates disease's underlying causes in mice, finds compounds that normalize Alzheimer's brain

Lipoprotein receptor LRP1 also regulates food intake and energy balance in central nervous system: Study

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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