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UI chemists debunk misconception about amphotericin

With one simple experiment, University of Illinois chemists have debunked a widely held misconception about an often-prescribed drug.

17 Jan 2012

Alcohol-dependent Americans more likely to seek treatment than South Koreans

Hazardous alcohol use and depression are among the 10 leading causes of disability and premature death worldwide, according to the World Health Organization. Many low- to middle-income countries have begun to see a steady increase in alcohol use and have entered the early stages of a tobacco epidemic. A study of alcohol use disorders (AUDs), nicotine dependence (ND), and mood and anxiety disorders in the United States and South Korea has found that while AUDs are substantially more common among Americans than South Koreans, alcohol-dependent Americans are significantly more likely to seek treatment.

17 Jan 2012

Combination of lapatinib and trastuzumab more effective in treating HER2-positive breast cancer

Using two drugs that inhibit the growth factor HER2 for preoperative treatment of early-stage HER2-positive breast cancer appears to have better results than treatment with a single agent. In a report in the January 17 issue of The Lancet, an international research team reports that a protocol adding lapatinib (Tykerb) to trastuzumab (Herceptin) was more effective than single-drug treatment with either drug in eliminating microscopic signs of cancer at the time the tumors were surgically removed.

17 Jan 2012

Matted lymph nodes may predict throat cancer metastasis

Researchers at the University of Michigan Health System have found a new indicator that may predict which patients with a common type of throat cancer are most likely have the cancer spread to other parts of their bodies.

17 Jan 2012

Researchers discover HS1.2 enhancer as the cause of SLE

A "genetic accelerator" is responsible for the most severe cases of Lupus (systemic lupus erythemathosus), an autoimmune disease: the accelerator, called enhancer HS1.2, speeds up the activity of some critical genes of the immune system involved in the disease.

17 Jan 2012

Hormone that burns energy discovered

Boston scientists have found a hormone that is secreted by muscles during exercise and boosts the amount of energy the body burns. This hormone – irisin – could be the first step in development of new drugs for obesity, diabetes, and other diseases feel researchers. A Boston startup company, Ember Therapeutics, has already licensed the technology and is working to develop a form of the hormone that could be used as a drug that would mimic some of the benefits of exercise.

16 Jan 2012

Heavy drinking may reinforce itself by stimulating endorphin release: Study

A new study has shown that drinking alcohol causes a pleasant feeling because it releases endorphins, the brain’s natural opioids. It adds that problem drinkers differ from social drinkers in the way alcohol affects one part of the brain. The report appeared Wednesday in Science Translational Medicine.

15 Jan 2012

Viewpoints: GOP moving away from compassionate conservatism; Competing strategies for fighting obesity

Romney asserts that President Obama wants to "fundamentally transform America," turning the country "into a European-style entitlement society." In fact, (Mitt) Romney and his Republican presidential rivals have a far more radical transformation in mind. They envision a dramatically shrunken federal government and a dangerously unraveled social safety net.

13 Jan 2012

Work of WHO essential medicines department at risk due to funding shortage, Oxfam warns

"The work of the essential medicines department of the World Health Organization (WHO) is under threat because of a serious shortage of funds, says a worrying and important letter published in the Lancet [on Thursday]," Guardian Health Editor Sarah Boseley reports in her "Global Health Blog."

13 Jan 2012

CVS agrees to pay $5M to settle Medicare drug false advertising claims

After more than two years of investigation, CVS Caremark agreed on Thursday to pay $5 million to settle charges by the Federal Trade Commission that the company had misrepresented the price of certain prescription drugs in one of its Medicare drug plans, causing many older consumers to pay significantly higher prices than advertised.

13 Jan 2012

Medicine may not be a remedy for heartburn

ABC News on December 27th, 2011 with Diane Sawyer featured "Reports of Acid Reflux Symptoms Double" and the epidemic in heartburn issues amongst the United States population, attributing the eating habits of the Baby Boomer generation as the primary cause.

13 Jan 2012

ViroPharma's NDS for Cinryze receives Health Canada's Priority Review status

ViroPharma Incorporated today announced that Health Canada has granted the company Priority Review status for its New Drug Submission (NDS) for Cinryze (C1 inhibitor [human]).

13 Jan 2012

First Edition: January 13, 2012

"The much celebrated, and much maligned, public option may have died in Congress, but it's alive and well in California. Unique in the nation for having public health insurance plans that are run by counties, California has plans that stretch from San Francisco to the Mexican border and cover 2.5 million residents"

13 Jan 2012

Smart injectable nanotherapeutics could improve treatment for Type I diabetes

A research collaboration between the Wyss Institute for Biologically Inspired Engineering at Harvard University and Children's Hospital Boston has developed "smart" injectable nanotherapeutics that can be programmed to selectively deliver drugs to the cells of the pancreas. Although this nanotechnology will need significant additional testing and development before being ready for clinical use, it could potentially improve treatment for Type I diabetes by increasing therapeutic efficacy and reducing side effects.

13 Jan 2012

Researchers publish first detailed figures that show risk of Rasilez and ACE inhibitors or ARBs

Researchers at St. Michael's Hospital have published the first detailed figures showing the risk of using the prescription drug Rasilez in combination with certain other blood pressure-lowering medications.

13 Jan 2012

AICAR might protect against heat stress in MH-susceptible individuals

Malignant hyperthermia (MH) is a life-threatening genetic muscle disorder, most commonly triggered in those at risk by certain types of drugs used during anesthesia. Heat stroke, on the other hand, most commonly occurs in individuals in response to physical exertion in hot/humid environments. While their common triggers may differ, the signs associated with MH and heat stroke are remarkably similar - uncontrolled muscle contractions, dangerous increases in body temperature, and muscle breakdown leading to the release of toxins in the blood which may cause cardiac arrhythmias and death. Immediate treatment for these conditions is crucial.

13 Jan 2012

Study shows how Notch gene and PRC2 protein complex work together to cause T-ALL

A new study published in the journal Nature Medicine by NYU Cancer Institute researchers, shows how the cancer causing gene Notch, in combination with a mutated Polycomb Repressive Complex 2 (PRC2) protein complex, work together to cause T- cell acute lymphoblastic leukemia.

13 Jan 2012

Kedem commences development of Gleevec to treat CML in children and adults

Kedem Pharmaceuticals Inc., a specialty pharmaceutical company with focus on sublingual drug delivery system is pleased to announce that has initiated the development of Gleevec.

12 Jan 2012

Ocular drug delivery: DSM awarded membership in PANOPTES EU Funded Consortium

DSM, a global leader in biomedical materials sciences, today announced that it is contributing proprietary knowledge in the preparation of tailored amino acid-based polymers and offering use of processing facilities that will produce an innovative step change in the sustained delivery of drug molecules. The PANOPTES consortium’s goal is to research and develop novel drug delivery technology for the posterior eye segment. This partnership further validates the innovative properties of DSM’s polyesteramide (PEA) biomaterials as a superior drug delivery technology.

12 Jan 2012

Study shows how new electronic medication management system reduces drug administration errors

Errors in administration of medication are a serious problem in long-term residential care. New research completed by the University of Warwick and the University of the West of England, Bristol (UWE) shows how a new electronic medication management system developed in the UK specifically for use in residential and nursing homes, has been shown to significantly reduce drug administration errors.

12 Jan 2012