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Hydroxychloroquine shown to slow recovery for COVID-19 patients

As researchers try to piece together a therapeutic strategy against the ongoing COVID-19 pandemic, a recent retrospective study from Cleveland Clinic Abu Dhabi, assessed the Hydroxychloroquine's efficacy in increasing SARS-CoV-2 viral clearance, finding that it appeared to significantly slow viral clearance in mild to moderately ill COVID-19 patients.

5 May 2020

An extended SAR analysis of lipophilic guanylhydrazone analogues as promising trypanocidal agents

Sleeping sickness and Chagas disease, caused by the tropical parasites Trypanosoma brucei and Trypanosoma cruzi, constitute a significant socioeconomic burden in low-income countries of sub-Saharan Africa and Latin America, respectively.

2 May 2020

Nanodevices could prevent plaque formation in the brain

Alzheimer's disease is the sixth leading cause of death in the United States, affecting one in 10 people over the age of 65. Scientists are engineering nanodevices to disrupt processes in the brain that lead to the disease.

30 Apr 2020

Remdesivir shows powerful activity against SARS-CoV-2 in Vitro

Remdesivir is an antiviral first developed by Gilead in 2014 as a treatment for Ebola and Marburg viruses. However, scientists explored its possibilities as a broad-spectrum drug when it proved effective against SARS-CoV and MERS-CoV, coronaviruses which were responsible for earlier outbreaks.

30 Apr 2020

Online searches for unproven therapies for COVID-19

A new observational study by a group of scientists explores the rise in the public's fear-driven interest in unproven therapies for COVID-19, particularly chloroquine and hydroxychloroquine, by tracking the internet searches relating to the purchase of drugs in news reports or publicized by public figures. They conclude: "Stay grounded in evidence and fight misinformation." The research letter and accompanying editorial comment are published in the journal JAMA Internal Medicine.

29 Apr 2020

Coronaviruses represent a source of pandemic viruses

In a new paper published on the preprint journal bioRxiv in April 2020, researcher T. Konishi argues that the coronavirus family is a constellation of pandemic pathogens, that includes the currently spreading severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

29 Apr 2020

Tapping into the powers of nature to identify virus killers

Many organisms have to defend themselves against predators, diseases or pests. Their metabolic products constitute a chemical arsenal that has been used for medical purposes since time immemorial.

29 Apr 2020

Ortho introduces second COVID-19 antibody test with 100% specificity

Ortho Clinical Diagnostics, a global leader of in vitro diagnostics with a rich history of bringing critical tests for infectious diseases to market, today introduced and announced the U.S. Food and Drug Administration granted Emergency Use Authorization to its second COVID-19 antibody test—the VITROS Immunodiagnostic Products Anti-SARS-CoV-2 IgG Test. This test is one of only a handful of antibody tests to be granted Emergency Use Authorization.

From Ortho-Clinical Diagnostics, Inc. 29 Apr 2020

Study explores the growth rate effect of gut bacteria on break down of dietary fibers

It is known that approximately 80% of human immune system functions in the gastrointestinal tract. Gut bacteria and their metabolites play a fundamental role in the interaction between gut and other organs.

29 Apr 2020

How toxic are chloroquine and hydroxychloroquine to cells?

The spread of the pandemic disease COVID-19 caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has now reached almost every country of the world, with over 3.11 million cases and over 217,000 deaths as of April 29, 2020.

29 Apr 2020

Researchers receive ERC grant to speed up the diagnosis of autoimmune encephalitis

Autoimmune encephalitis (AE) is a disease that affects 2-3 people out of 100,000, in which our immune system attacks our own brain causing neurological and psychiatric symptoms.

28 Apr 2020

Researchers recreate how toxins from smoking cause DNA damage

Researchers from the University of York have recreated how toxins from smoking cause unique patterns of DNA damage.

28 Apr 2020

Researchers discover a new mode of protein degradation by ubiquitin-proteasome system

The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins.

28 Apr 2020

Study marks a major step towards beta cell replacement therapy

The loss of insulin-secreting beta cells by autoimmune destruction leads to type 1 diabetes. Clinical islet cell transplantation has the potential to cure diabetes, but donor pancreases are rare.

28 Apr 2020

The approved dose of ivermectin alone not useful in treating COVID-19

A new paper published on the preprint server medRxiv in April 2020 shows that the use of the already approved drug ivermectin in clinical trials to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)s not feasible. This contradicts earlier reports of its ability to suppress the virus in vitro.

27 Apr 2020

SARS-CoV-2 readily infects human intestinal cells in a laboratory model

A new Dutch study available on bioRxiv uses differentiated human small intestinal organoids in vitro to demonstrate that intestinal epithelium supports the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and elicits a strong generic immune response.

27 Apr 2020

Researchers harness the power of AI to accelerate drug discovery

As the COVID-19 crisis continues to develop, researchers around the world are attempting to find the most effective treatment to combat the poorly understood virus behind this disease.

27 Apr 2020

SARS-CoV-2 spike protein discovery could pave way for COVID-19 vaccine

Researchers at the Indian Institute of Technology, Guwahati, have made an important discovery about a viral fusion protein found on the surface of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could help researchers develop a vaccine.

27 Apr 2020

Cannabidiol could be a useful therapy for difficult-to-treat brain cancer

Findings from a new study examining human and canine brain cancer cells suggest that cannabidiol could be a useful therapy for a difficult-to-treat brain cancer. Cannabidiol, or CBD, is a non-psychoactive chemical compound derived from marijuana.

27 Apr 2020

Study can serve as basis for developing new approaches for obesity, diabetes

In the 21st century, the search for methods of treating noncommunicable diseases, such as obesity, metabolic syndrome, and diabetes are among the top priorities.

24 Apr 2020