Allodynia News and Research

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Allodynia, meaning "other pain", is a painful (noxious) response to a usually non-painful (innocuous) stimulus and can be either static or mechanical. Allodynia differs from referred pain, but can occur in areas other than the one stimulated. It is dysesthetic. Allodynia is different from hyperalgesia, an extreme reaction to a stimulus which is normally painful.

Neuroimaging study reveals structural changes in the brain of migraine patients

A neuroimaging study recently published in the journal Cephalalgia, the official journal of the International Headache Society, shared more evidence of structural changes in the brain of migraine patients.

13 Jan 2020

Meta-analysis highlights predictors of chronic migraine

A meta-analysis published in the journal Cephalalgia, the official journal of the International Headache Society, highlights the predictors of chronic migraine.

7 Jan 2020

Brain protein plays a prominent role in the maintenance of chronic pain

A protein called RGS4 (Regulator of G protein signaling 4) plays a prominent role in the maintenance of long-term pain states and may serve as a promising new target for the treatment of chronic pain conditions, according to research conducted at the Icahn School of Medicine at Mount Sinai and published in print October 16, in The Journal of Neuroscience.

11 Oct 2019

Protein implicated in neuron growth and cell adhesion appears crucial for pain sensitization

Researchers from Japan's Osaka University have made an important leap in our understanding of how chronic pain conditions develop.

20 Aug 2019

Scientists discover new pain-sensing organ underneath the skin

Researchers have discovered a new sensory organ located underneath the skin. The discovery could lead to the development of new, more effective pain killers.

19 Aug 2019

Effective dose of cannabidiol for safe pain relief without the typical 'high'

In the wake of cannabis legalization, a team of scientists at the Research Institute of the McGill University Health Center and McGill University have delivered encouraging news for chronic pain sufferers by pinpointing the effective dose of marijuana plant extract cannabidiol for safe pain relief without the typical "high" or euphoria produced by the THC.

25 Oct 2018

Dectin-1 pathway could be important new target for treatment of candidiasis, study shows

Candida albicans infection (candidiasis) can cause skin, genital, or oral pain. Many studies have attempted to understand the source of pain in candidiasis; none have provided a clear explanation, until now.

29 Aug 2018

Columbia researchers identify nerve cells that drive fruit fly's escape behavior

Columbia University researchers have identified the nerve cells that initiate a fly's escape response: that complex series of movements in which an animal senses, and quickly maneuvers away from, something harmful such as high heat.

20 Mar 2018

Pioneering study may pave way for effective painkillers to treat neuropathic pain

A pioneering international study, carried out by the University of Granada, Harvard University, the University of California, Los Angeles, the University of Florida, Laval University and the Jackson Laboratory has conducted an in-depth analysis of the molecular differences between the most common symptoms associated with neuropathic pain.

21 Feb 2018

Researchers show how dopamine falls and fluctuates during migraine headache

Using PET scans of the brain, University of Michigan researchers showed that dopamine falls and fluctuates at different times during a migraine headache.

29 Mar 2017

Highly caffeinated alcoholic drinks may induce changes in the adolescent brain similar to cocaine

Drinking highly caffeinated alcoholic beverages triggers changes in the adolescent brain similar to taking cocaine, and the consequences last into adulthood as an altered ability to deal with rewarding substances, according to a Purdue University study.

25 Oct 2016

Botulinum toxin A injections combat neuropathic pain

Botulinum toxin A injections have a sustained beneficial effect in patients with neuropathic pain, shows a randomised trial.

3 Mar 2016

Canadian researchers shed light on molecular dynamics of chronic pain

Chronic pain affects hundreds of millions of people worldwide and is a major cause of disability, causing more disability than cancer and heart disease. Canadian researchers, including Michael Salter at SickKids are shedding light on the molecular dynamics of chronic pain. They have uncovered a critical role for a class of cells present in the brain and spinal cord, called microglia, in pain.

27 May 2015

Researchers identify important neural mechanism responsible for certain chronic pain disorders

Pain typically has a clear cause-but not always. When a person touches something hot or bumps into a sharp object, it's no surprise that it hurts. But for people with certain chronic pain disorders, including fibromyalgia and phantom limb pain, a gentle caress can result in agony.

6 Dec 2014

Research shows mustard and garlic receptor is linked to cold-induced pain

Some people experience cold not only as feeling cold, but actually as a painful sensation. This applies even to fairly mild temperatures - anything below 20°C.

14 Nov 2014

Molecular mechanisms underlying effects of acupuncture on neuropathic pain

Peripheral or central nerve injury often leads to neuropathic pain, a chronic condition that can manifest behaviorally as spontaneous pain, hyperalgesia and allodynia, and which also results in neurological dysfunction.

6 Nov 2013

Winners of EFIC-Grünenthal-Grant announced

For the 8th time the European Federation of IASP Chapters in cooperation with the pharmaceutical company Grünenthal Group announced the EFIC-Grünenthal-Grant (E-G-G) - a grant aimed to support young scientists at an early stage of their experimental projects on clinical and human volunteer-based pain research.

6 Jun 2013

Nearly 1/10 stroke patients suffer from chronic and debilitating pain

Nearly 1 in 10 stroke patients suffer chronic and debilitating pain, typically described as sharp, stabbing or burning. It's called central poststroke pain syndrome (CPSP). It was first described more than 100 years ago, and it is treatable with medications and magnetic or electrical stimulation of the brain.

9 May 2013

Scientists identify molecular mechanism central to development of osteoarthritis pain

Researchers at Rush University Medical Center, in collaboration with researchers at Northwestern University, have identified a molecular mechanism central to the development of osteoarthritis (OA) pain, a finding that could have major implications for future treatment of this often-debilitating condition.

28 Dec 2012

Companionship can reduce nerve-related pain

Companionship has the potential to reduce pain linked to nerve damage, according to a new study.

16 Oct 2012